Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.
Zhao-Xin Wang; John X. Zhang; Qiu-Lin Wu; Ning Liu; Xiao-Ping Hu; Raymond C.K. Chan; Zhuang-Wei Xiao; J.X. Zhang,Z.-W. Xiao
2010
发表期刊Neuroimage
通讯作者邮箱jxzhang@cuhk.edu.hk ; xiaozw@vip.163.com
卷号49期号:1页码:971-976
产权排序5
摘要Long-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affective materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry.
关键词Addiction Heroin Affective processing Emotion Amygdala Visual cortex
学科领域生理心理学/生物心理学
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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10059
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J.X. Zhang,Z.-W. Xiao
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GB/T 7714
Zhao-Xin Wang,John X. Zhang,Qiu-Lin Wu,et al. Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.[J]. Neuroimage,2010,49(1):971-976.
APA Zhao-Xin Wang.,John X. Zhang.,Qiu-Lin Wu.,Ning Liu.,Xiao-Ping Hu.,...&J.X. Zhang,Z.-W. Xiao.(2010).Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts..Neuroimage,49(1),971-976.
MLA Zhao-Xin Wang,et al."Alterations in the processing of non-drug-related affective stimuli in abstinent heroin addicts.".Neuroimage 49.1(2010):971-976.
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