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Brain Anatomical Abnormalities in High-Risk Individuals, First-Episode, and Chronic Schizophrenia: An Activation Likelihood Estimation Meta-analysis of Illness Progression
Chan, Raymond C. K.1,2,3; Di, Xin4; McAlonan, Grainne M.3,5; Gong, Qi-yong6; Chan, RCK (reprint author), Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
2011
Source PublicationSCHIZOPHRENIA BULLETIN
Correspondent Emailrckchan@psych.ac.cn
ISSN0586-7614
SubtypeArticle
Volume37Issue:1Pages:177-188
Contribution Rank2
AbstractObjective: The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with chronic schizophrenia. We predicted that gray matter abnormalities would show progressive changes, with most extensive abnormalities in the chronic group relative to FES and least in the high-risk group. Method: Forty-one VBM studies were reviewed. Eight high-risk studies, 14 FES studies, and 19 chronic studies were analyzed using anatomical likelihood estimation meta-analysis. Results: Less gray matter in the high-risk group relative to controls was observed in anterior cingulate regions, left amygdala, and right insula. Lower gray matter volumes in FES compared with controls were also found in the anterior cingulate and right insula but not the amygdala. Lower gray matter volumes in the chronic group were most extensive, incorporating similar regions to those found in FES and high-risk groups but extending to superior temporal gyri, thalamus, posterior cingulate, and parahippocampal gryus. Subtraction analysis revealed less frontotemporal, striatal, and cerebellar gray matter in FES than the high-risk group; the high-risk group had less gray matter in left subcallosal gyrus, left amygdala, and left inferior frontal gyrus compared with FES. Subtraction analysis confirmed lower gray matter volumes through ventral-dorsal anterior cingulate, right insula, left amygdala and thalamus in chronic schizophrenia relative to FES. Conclusions: Frontotemporal brain structural abnormalities are evident in nonpsychotic individuals at high risk of developing schizophrenia. The present meta-analysis indicates that these gray matter abnormalities become more extensive through first-episode and chronic illness. Thus, schizophrenia appears to be a progressive cortico-striato-thalamic loop disorder.
Keywordmeta-analysis brain structure high-risk group schizophrenia
Subject AreaAbnormal Psychology
DOI10.1093/schbul/sbp073
URL查看原文
Indexed BySSCI
Language英语
Funding OrganizationProject-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; National Natural Science Foundation of China [30770723] ; National Basic Research Programme (973 Programme) [2007CB512302, 2007CB512305]
Project Intro.Project-Oriented Hundred Talents Programme (O7CX031003); Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131); National Natural Science Foundation of China (30770723 to R.C.K.C.); National Basic Research Programme (973 Programme No. 2007CB512302 and 2007CB512305).
WOS IDWOS:000285845300022
Citation statistics
Cited Times:165[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10061
Collection脑与认知科学国家重点实验室
Corresponding AuthorChan, RCK (reprint author), Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
4.Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China
5.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
6.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Di, Xin,McAlonan, Grainne M.,et al. Brain Anatomical Abnormalities in High-Risk Individuals, First-Episode, and Chronic Schizophrenia: An Activation Likelihood Estimation Meta-analysis of Illness Progression[J]. SCHIZOPHRENIA BULLETIN,2011,37(1):177-188.
APA Chan, Raymond C. K.,Di, Xin,McAlonan, Grainne M.,Gong, Qi-yong,&Chan, RCK .(2011).Brain Anatomical Abnormalities in High-Risk Individuals, First-Episode, and Chronic Schizophrenia: An Activation Likelihood Estimation Meta-analysis of Illness Progression.SCHIZOPHRENIA BULLETIN,37(1),177-188.
MLA Chan, Raymond C. K.,et al."Brain Anatomical Abnormalities in High-Risk Individuals, First-Episode, and Chronic Schizophrenia: An Activation Likelihood Estimation Meta-analysis of Illness Progression".SCHIZOPHRENIA BULLETIN 37.1(2011):177-188.
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