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Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats
Shi, Miao2,3; Wang, Jin-Yan1; Luo, Fei1,2,3; Jin-Yan Wang,Fei Luo
2010-03-01
Source PublicationJOURNAL OF PAIN
Correspondent Emailwangjy@psych.ac.cn ; luof@psych.ac.cn
ISSN1526-5900
SubtypeArticle
Volume11Issue:3Pages:219-229
Contribution Rank1
AbstractAlthough it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The present study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception and hyperalgesia) and spontaneous pain behavior (formalin pain) in rats. An unpredictable chronic mild stress (UCMS) paradigm was employed to develop a classical depression. The emotional behaviors were assessed by sucrose preference test, open field test, and elevated plus-maze test. The results showed that the depressed rats always exhibited stronger tolerance to noxious thermal stimulation under both normal and complete Freund's adjuvant (CFA)-induced chronic pain conditions, when compared to nondepressed animals. Interestingly, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in rats exposed to UCMS in comparison to those without UCMS. Systemic administration of antidepressant fluoxetine significantly restored the nociceptive behaviors to normal level in depressed animals. An additional finding was that the inflammatory rats tended to display depressive-like behaviors without being exposed to UCMS. These results demonstrated that depression can have different effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter.
KeywordDepression fluoxetine pain thermal hyperalgesia unpredictable chronic mild stress
Subject Area生理心理学/生物心理学
DOI10.1016/j.jpain.2009.07.002
Indexed BySCI
Language英语
Funding OrganizationFunded by a NNSF grant, and a grant for young scientists from the Chinese Academy of Sciences to J.Y.W.;NNSF grants, the 100 Talented Plan of the Chinese Academy of Sciences, a grant from the 863 project , and a grant from NIH Fogarty International Center to F.L.
Funding ProjectFunded by a NNSF grant (30700223), and a grant for young scientists (07CX051005) from the Chinese Academy of Sciences to J.Y.W.;NNSF grants (30570577and30770688), the 100 Talented Plan of the Chinese Academy of Sciences, a grant from the 863 project (2006AA02Z431), and a grant from NIH Fogarty International Center (1R03TW008038) to F.L.
WOS IDWOS:000277092100003
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10073
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJin-Yan Wang,Fei Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Peking Univ, Dept Neurobiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Shi, Miao,Wang, Jin-Yan,Luo, Fei,et al. Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats[J]. JOURNAL OF PAIN,2010,11(3):219-229.
APA Shi, Miao,Wang, Jin-Yan,Luo, Fei,&Jin-Yan Wang,Fei Luo.(2010).Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats.JOURNAL OF PAIN,11(3),219-229.
MLA Shi, Miao,et al."Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats".JOURNAL OF PAIN 11.3(2010):219-229.
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