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Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks
He, Xingu1,2; Xiao, Lin1; Sui, Nan1; Nan Sui
2010-02-10
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
Correspondent Emailsuin@psych.ac.cn
ISSN0014-2999
SubtypeArticle
Volume627Issue:1-3Pages:136-141
Contribution Rank1
Abstract.; In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various behavioral paradigms, such as one-trial passive avoidance learning. However, it is not yet clear whether the dopaminergic system of these regions is responsible for associative learning underlying cue-elicited drug reward. In this study, a 6-day conditioning schedule in day-old chicks with i.p. morphine (2 mg/kg) was used to compare the effects of intracerebrally injected dopamine D(1) receptor antagonist, SCH23390, and D(2) antagonist, spiperone. The antagonists were injected bilaterally (3 mu g/site) into either the medial striatum or the intermediate medial mesopallium, and tests were conducted on morphine-induced conditioned place preference or locomotor activity. The acquisition of place preference was significantly inhibited by SCH23390 in either the medial striatum or the intermediate medial mesopallium, but not by spiperone. However, in the medial striatum, but not in the intermediate medial mesopallium, the locomotor activity was blocked by both SCH23390 and spiperone. These data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine D(1) system may play an important role in the development of opiate reward. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
KeywordMorphine Conditioned place preference The medial striatum The intermediate medial mesopallium Reward-related learning Day-old chicks
Subject Area生理心理学/生物心理学
DOI10.1016/j.ejphar.2009.10.041
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000274093800020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10077
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorNan Sui
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
He, Xingu,Xiao, Lin,Sui, Nan,et al. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,627(1-3):136-141.
APA He, Xingu,Xiao, Lin,Sui, Nan,&Nan Sui.(2010).Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks.EUROPEAN JOURNAL OF PHARMACOLOGY,627(1-3),136-141.
MLA He, Xingu,et al."Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks".EUROPEAN JOURNAL OF PHARMACOLOGY 627.1-3(2010):136-141.
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