Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks
He, Xingu1,2; Xiao, Lin1; Sui, Nan1; Nan Sui
2010-02-10
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
通讯作者邮箱suin@psych.ac.cn
ISSN0014-2999
文章类型Article
卷号627期号:1-3页码:136-141
产权排序1
摘要.; In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various behavioral paradigms, such as one-trial passive avoidance learning. However, it is not yet clear whether the dopaminergic system of these regions is responsible for associative learning underlying cue-elicited drug reward. In this study, a 6-day conditioning schedule in day-old chicks with i.p. morphine (2 mg/kg) was used to compare the effects of intracerebrally injected dopamine D(1) receptor antagonist, SCH23390, and D(2) antagonist, spiperone. The antagonists were injected bilaterally (3 mu g/site) into either the medial striatum or the intermediate medial mesopallium, and tests were conducted on morphine-induced conditioned place preference or locomotor activity. The acquisition of place preference was significantly inhibited by SCH23390 in either the medial striatum or the intermediate medial mesopallium, but not by spiperone. However, in the medial striatum, but not in the intermediate medial mesopallium, the locomotor activity was blocked by both SCH23390 and spiperone. These data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine D(1) system may play an important role in the development of opiate reward. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
关键词Morphine Conditioned place preference The medial striatum The intermediate medial mesopallium Reward-related learning Day-old chicks
学科领域生理心理学/生物心理学
DOI10.1016/j.ejphar.2009.10.041
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000274093800020
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10077
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Nan Sui
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
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He, Xingu,Xiao, Lin,Sui, Nan,et al. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,627(1-3):136-141.
APA He, Xingu,Xiao, Lin,Sui, Nan,&Nan Sui.(2010).Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks.EUROPEAN JOURNAL OF PHARMACOLOGY,627(1-3),136-141.
MLA He, Xingu,et al."Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks".EUROPEAN JOURNAL OF PHARMACOLOGY 627.1-3(2010):136-141.
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