Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice | |
Yuan, Xiao-Ying1,2; Liu, Wei1,2; Zhang, Ping1; Wang, Rui-Yan1; Guo, Jian-You3 ; Xiao-Ying Yuan,Jian-You Guo
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| 通讯作者邮箱 | tata1hao@yahoo.com.cn ; guojy@psych.ac.cn |
| 心理所单位排序 | 3 |
| 摘要 | Allergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response. Multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. Aloperine is an isolated alkaloid found in the plant of Sophora alopecuroides L. It has been clinically proved effective in China for a long time for skin inflammatory diseases such as allergic contact dermatitis. However, the mechanism of aloperine on allergic contact dermatitis is largely unknown. Therefore, the aim of this study was to investigate the effect of aloperine on 2, 4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis in BALB/c mice and the possible underlying mechanisms. The results showed that topical application of DNFB on the car provoked typical allergic contact dermatitis with ear swelling and ear erythema in BALB/c mice. Treatments with 1% aloperine suppressed DNFB-induced increase in ear thickness and ear erythema. Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates. Our findings suggest that aloperine greatly improves the DNFB-induced allergic contact dermatitis in mice. The therapeutic mechanism might be related to the reduction of TNF-alpha, IL-1 beta and IL-6 production induced by DNFB. (C) 2009 Elsevier B.V. All rights reserved. |
| 关键词 | Aloperine Allergic contact dermatitis Tumor necrosis factor-alpha Interleukin-1 beta Interleukin-6 |
| 学科领域 | 生理心理学/生物心理学 |
| 2010-03-10 | |
| 语种 | 英语 |
| DOI | 10.1016/j.ejphar |
| 发表期刊 | EUROPEAN JOURNAL OF PHARMACOLOGY
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| ISSN | 0014-2999 |
| 卷号 | 629期号:1-3页码:147-152 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| WOS记录号 | WOS:000275004900023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/10079 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Xiao-Ying Yuan,Jian-You Guo |
| 作者单位 | 1.Gen Hosp Air Force, Dept Dermatol, Beijing 1000142, Peoples R China 2.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,629(1-3):147-152. |
| APA | Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,Wang, Rui-Yan,Guo, Jian-You,&Xiao-Ying Yuan,Jian-You Guo.(2010).Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.EUROPEAN JOURNAL OF PHARMACOLOGY,629(1-3),147-152. |
| MLA | Yuan, Xiao-Ying,et al."Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice".EUROPEAN JOURNAL OF PHARMACOLOGY 629.1-3(2010):147-152. |
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