PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
Yuan, Xiao-Ying1,2; Liu, Wei1,2; Zhang, Ping1; Wang, Rui-Yan1; Guo, Jian-You3; Xiao-Ying Yuan,Jian-You Guo
2010-03-10
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
Correspondent Emailtata1hao@yahoo.com.cn ; guojy@psych.ac.cn
ISSN0014-2999
SubtypeArticle
Volume629Issue:1-3Pages:147-152
Contribution Rank3
AbstractAllergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response. Multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. Aloperine is an isolated alkaloid found in the plant of Sophora alopecuroides L. It has been clinically proved effective in China for a long time for skin inflammatory diseases such as allergic contact dermatitis. However, the mechanism of aloperine on allergic contact dermatitis is largely unknown. Therefore, the aim of this study was to investigate the effect of aloperine on 2, 4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis in BALB/c mice and the possible underlying mechanisms. The results showed that topical application of DNFB on the car provoked typical allergic contact dermatitis with ear swelling and ear erythema in BALB/c mice. Treatments with 1% aloperine suppressed DNFB-induced increase in ear thickness and ear erythema. Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates. Our findings suggest that aloperine greatly improves the DNFB-induced allergic contact dermatitis in mice. The therapeutic mechanism might be related to the reduction of TNF-alpha, IL-1 beta and IL-6 production induced by DNFB. (C) 2009 Elsevier B.V. All rights reserved.
KeywordAloperine Allergic contact dermatitis Tumor necrosis factor-alpha Interleukin-1 beta Interleukin-6
Subject Area生理心理学/生物心理学
DOI10.1016/j.ejphar
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000275004900023
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10079
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorXiao-Ying Yuan,Jian-You Guo
Affiliation1.Gen Hosp Air Force, Dept Dermatol, Beijing 1000142, Peoples R China
2.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,629(1-3):147-152.
APA Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,Wang, Rui-Yan,Guo, Jian-You,&Xiao-Ying Yuan,Jian-You Guo.(2010).Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.EUROPEAN JOURNAL OF PHARMACOLOGY,629(1-3),147-152.
MLA Yuan, Xiao-Ying,et al."Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice".EUROPEAN JOURNAL OF PHARMACOLOGY 629.1-3(2010):147-152.
Files in This Item:
File Name/Size DocType Version Access License
Effects%20and%20mech(721KB) 限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan, Xiao-Ying]'s Articles
[Liu, Wei]'s Articles
[Zhang, Ping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan, Xiao-Ying]'s Articles
[Liu, Wei]'s Articles
[Zhang, Ping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Xiao-Ying]'s Articles
[Liu, Wei]'s Articles
[Zhang, Ping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Effects%20and%20mechanisms%20of%20aloperine%20on%202___%204-dinitrofluorobenzene-induced%20allergic%20contact%20dermatitis%20in%20BALBc__%20mice[1].pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.