Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
Yuan, Xiao-Ying1,2; Liu, Wei1,2; Zhang, Ping1; Wang, Rui-Yan1; Guo, Jian-You3; Xiao-Ying Yuan,Jian-You Guo
2010-03-10
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
通讯作者邮箱tata1hao@yahoo.com.cn ; guojy@psych.ac.cn
ISSN0014-2999
文章类型Article
卷号629期号:1-3页码:147-152
产权排序3
摘要Allergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response. Multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. Aloperine is an isolated alkaloid found in the plant of Sophora alopecuroides L. It has been clinically proved effective in China for a long time for skin inflammatory diseases such as allergic contact dermatitis. However, the mechanism of aloperine on allergic contact dermatitis is largely unknown. Therefore, the aim of this study was to investigate the effect of aloperine on 2, 4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis in BALB/c mice and the possible underlying mechanisms. The results showed that topical application of DNFB on the car provoked typical allergic contact dermatitis with ear swelling and ear erythema in BALB/c mice. Treatments with 1% aloperine suppressed DNFB-induced increase in ear thickness and ear erythema. Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates. Our findings suggest that aloperine greatly improves the DNFB-induced allergic contact dermatitis in mice. The therapeutic mechanism might be related to the reduction of TNF-alpha, IL-1 beta and IL-6 production induced by DNFB. (C) 2009 Elsevier B.V. All rights reserved.
关键词Aloperine Allergic contact dermatitis Tumor necrosis factor-alpha Interleukin-1 beta Interleukin-6
学科领域生理心理学/生物心理学
DOI10.1016/j.ejphar
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000275004900023
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10079
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Xiao-Ying Yuan,Jian-You Guo
作者单位1.Gen Hosp Air Force, Dept Dermatol, Beijing 1000142, Peoples R China
2.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,629(1-3):147-152.
APA Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,Wang, Rui-Yan,Guo, Jian-You,&Xiao-Ying Yuan,Jian-You Guo.(2010).Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.EUROPEAN JOURNAL OF PHARMACOLOGY,629(1-3),147-152.
MLA Yuan, Xiao-Ying,et al."Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice".EUROPEAN JOURNAL OF PHARMACOLOGY 629.1-3(2010):147-152.
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