Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data

doi:10.1093/schbul/sbn190.

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	Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data
	Li, Huijie1,2,3 ; Chan, Raymond C. K.1,2,3,4 ; McAlonan, Grainne M.4,5; Gong, Qi-yong 6
摘要	Background: People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when processing facial emotion. However, findings have not been entirely consistent across different studies. Methods: Activation likelihood estimation (ALE) meta-analyses were conducted to examine brain activation during facial emotion processing in patients with schizophrenia, controls, and patients compared with controls. Secondary meta-analyses were performed to assess the contribution of task design and illness chronicity to the results reported. Results: When processing facial expressions of emotions, both patients with schizophrenia and healthy controls activated the bilateral amygdala and right fusiform gyri. However, the extent of activation in these regions was generally much more limited in the schizophrenia samples. When directly compared with controls, the extent of activation in bilateral amygdala, parahippocampal gyrus and fusiform gyrus, right superior frontal gyrus, and lentiform nucleus was significantly less in patients. Patients with schizophrenia, but not controls, activated the left insula. A relative failure to recruit the amygdala in patients occurred regardless of whether the task design was explicit or implicit, while differences in fusiform activation were evident in explicit, not implicit, tasks. Restricting the analysis to patients with chronic illness did not substantially change the results. Conclusions: A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex "social brain" system may be central to the difficulties patients experience when processing facial emotion.
关键词	meta-analysis schizophrenia emotion perception amygdala
学科领域	认知神经科学
	2010-09-01
语种	英语
DOI	10.1093/schbul/sbn190.
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	36 期号:5 页码:1029-1039
期刊论文类型	Article
URL	查看原文
收录类别	SCI ; SSCI
WOS记录号	WOS:000281188100019
引用统计	被引频次：213[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10088
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Inst Psychol, Beijing 100101, Peoples R China 4.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 5.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 6.Sichuan Univ, W China Sch Med, W China Hosp, Huaxi MR Res Ctr,Dept Radiol, Chengdu 610064, Peoples R China
第一作者单位	认知与发展心理学研究室; 中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Huijie,Chan, Raymond C. K.,McAlonan, Grainne M.,et al. Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data[J]. SCHIZOPHRENIA BULLETIN,2010,36(5):1029-1039.
APA	Li, Huijie,Chan, Raymond C. K.,McAlonan, Grainne M.,&Gong, Qi-yong.(2010).Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data.SCHIZOPHRENIA BULLETIN,36(5),1029-1039.
MLA	Li, Huijie,et al."Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data".SCHIZOPHRENIA BULLETIN 36.5(2010):1029-1039.

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