Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population | |
So, Hon-Cheong1; Fong, Pui Y.2; Chen, Ronald Y. L.1; Hui, Tomy C. K.1; Ng, Mandy Y. M.2; Cherny, Stacey S.1,2,4; Mak, William W. M.2,3,5; Cheung, Eric F. C.; Chan, Raymond C. K.1,7,8 ; Chen, Eric Y. H.1,6; Li, Tao9,10; Sham, Pak C.1,2,4
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| 心理所单位排序 | 9 |
| 摘要 | Chromosome 3p was reported by previous studies as one of the regions showing strong evidence of linkage with schizophrenia. We performed a fine-mapping association study of a 6-Mb high-LD and gene-rich region on 3p in a Southern Chinese sample of 489 schizophrenia patients and 519 controls to search for susceptibility genes. In the initial screen, 4 SNPs out of the 144 tag SNPs genotyped were nominally significant (P < 0.05). One of the most significant SNPs (rs3732530, P = 0.0048) was a non-synonymous SNP in the neuroglycan C (NGC, also known as CSPG5) gene, which belongs to the neuregulin family. The gene prioritization program Endeavor ranked NGC 8th out of the 129 genes in the 6-Mb region and the highest among the genes within the same LD block. Further genotyping of NGC revealed 3 more SNPs to be nominally associated with schizophrenia. Three other genes (NRG1, ErbB3, ErbB4) involved in the neuregulin pathways were subsequently genotyped. Interaction analysis by multifactor dimensionality reduction (MDR) revealed a significant two-SNP interaction between NGC and NRG1 (P = 0.015) and three-SNP interactions between NRG1 and ErbB4 (P = 0.009). The gene NGC is exclusively expressed in the brain. It is implicated in neuro-development in rats and was previously shown to promote neurite outgrowth. Methamphetamine, a drug that may induce psychotic symptoms, was reported to alter the expression of NGC Taken together, these results suggest that NGC may be a novel candidate gene, and neuregulin signaling pathways may play an important role in schizophrenia. (C) 2009 Wiley-Liss, Inc. |
| 关键词 | neuregulin-1 CSPG5 ErbB4 genetic association interaction |
| 学科领域 | 变态心理学 |
| 2010 | |
| 语种 | 英语 |
| DOI | 10.1002/ajmg.b.30961 |
| 发表期刊 | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
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| ISSN | 1552-4841 |
| 卷号 | 153B期号:1页码:103-113 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| 资助项目 | Grant sponsor: University of Hong Kong Strategic Research Theme on Genomics; Grant sponsor: Hong Kong Research Grants Council General Research Fund; Grant number: 757905. |
| WOS记录号 | WOS:000273440500012 |
| 资助机构 | Grant sponsor: University of Hong Kong Strategic Research Theme on Genomics; Grant sponsor: Hong Kong Research Grants Council General Research Fund |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/10097 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, Genome Res Ctr, Hong Kong, Hong Kong, Peoples R China 3.Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China 4.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 5.Hong Kong Biotechnol Educ Resource Ctr, Hong Kong, Hong Kong, Peoples R China 6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 7.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 8.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 9.Kings Coll London, Div Psychol Med, London WC2R 2LS, England 10.Kings Coll London, SGDP Ctr, London WC2R 2LS, England |
| 推荐引用方式 GB/T 7714 | So, Hon-Cheong,Fong, Pui Y.,Chen, Ronald Y. L.,et al. Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2010,153B(1):103-113. |
| APA | So, Hon-Cheong.,Fong, Pui Y..,Chen, Ronald Y. L..,Hui, Tomy C. K..,Ng, Mandy Y. M..,...&Sham, Pak C..(2010).Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,153B(1),103-113. |
| MLA | So, Hon-Cheong,et al."Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 153B.1(2010):103-113. |
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