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Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population
So, Hon-Cheong1; Fong, Pui Y.2; Chen, Ronald Y. L.1; Hui, Tomy C. K.1; Ng, Mandy Y. M.2; Cherny, Stacey S.1,2,4; Mak, William W. M.2,3,5; Cheung, Eric F. C.; Chan, Raymond C. K.1,7,8; Chen, Eric Y. H.1,6; Li, Tao9,10; Sham, Pak C.1,2,4
2010
Source PublicationAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
ISSN1552-4841
SubtypeArticle
Volume153BIssue:1Pages:103-113
Contribution Rank9
AbstractChromosome 3p was reported by previous studies as one of the regions showing strong evidence of linkage with schizophrenia. We performed a fine-mapping association study of a 6-Mb high-LD and gene-rich region on 3p in a Southern Chinese sample of 489 schizophrenia patients and 519 controls to search for susceptibility genes. In the initial screen, 4 SNPs out of the 144 tag SNPs genotyped were nominally significant (P < 0.05). One of the most significant SNPs (rs3732530, P = 0.0048) was a non-synonymous SNP in the neuroglycan C (NGC, also known as CSPG5) gene, which belongs to the neuregulin family. The gene prioritization program Endeavor ranked NGC 8th out of the 129 genes in the 6-Mb region and the highest among the genes within the same LD block. Further genotyping of NGC revealed 3 more SNPs to be nominally associated with schizophrenia. Three other genes (NRG1, ErbB3, ErbB4) involved in the neuregulin pathways were subsequently genotyped. Interaction analysis by multifactor dimensionality reduction (MDR) revealed a significant two-SNP interaction between NGC and NRG1 (P = 0.015) and three-SNP interactions between NRG1 and ErbB4 (P = 0.009). The gene NGC is exclusively expressed in the brain. It is implicated in neuro-development in rats and was previously shown to promote neurite outgrowth. Methamphetamine, a drug that may induce psychotic symptoms, was reported to alter the expression of NGC Taken together, these results suggest that NGC may be a novel candidate gene, and neuregulin signaling pathways may play an important role in schizophrenia. (C) 2009 Wiley-Liss, Inc.
Keywordneuregulin-1 CSPG5 ErbB4 genetic association interaction
Subject Area变态心理学
DOI10.1002/ajmg.b.30961
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationGrant sponsor: University of Hong Kong Strategic Research Theme on Genomics; Grant sponsor: Hong Kong Research Grants Council General Research Fund
Funding ProjectGrant sponsor: University of Hong Kong Strategic Research Theme on Genomics; Grant sponsor: Hong Kong Research Grants Council General Research Fund; Grant number: 757905.
WOS IDWOS:000273440500012
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10097
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Genome Res Ctr, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
4.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
5.Hong Kong Biotechnol Educ Resource Ctr, Hong Kong, Hong Kong, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
9.Kings Coll London, Div Psychol Med, London WC2R 2LS, England
10.Kings Coll London, SGDP Ctr, London WC2R 2LS, England
Recommended Citation
GB/T 7714
So, Hon-Cheong,Fong, Pui Y.,Chen, Ronald Y. L.,et al. Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2010,153B(1):103-113.
APA So, Hon-Cheong.,Fong, Pui Y..,Chen, Ronald Y. L..,Hui, Tomy C. K..,Ng, Mandy Y. M..,...&Sham, Pak C..(2010).Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,153B(1),103-113.
MLA So, Hon-Cheong,et al."Identification of Neuroglycan C and Interacting Partners as Potential Susceptibility Genes for Schizophrenia in a Southern Chinese Population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 153B.1(2010):103-113.
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