Neurological Soft Signs in Schizophrenia: A Meta-analysis
Chan, Raymond C. K.1,2; Xu, Ting1,3,4; Heinrichs, R. Walter5; Yu, Yue1,6,7; Wang, Ya1,2; Raymond C. K. Chan
2010-11-01
发表期刊SCHIZOPHRENIA BULLETIN
通讯作者邮箱rckchan@psych.ac.cn
ISSN0586-7614
文章类型Article
卷号36期号:6页码:1089-1104
产权排序1
摘要Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%-10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness.
关键词neurological soft signs meta-analysis schizophrenia
学科领域变态心理学
DOI10.1093/schbul/sbp011
URL查看原文
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000283683800007
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被引频次:90[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10106
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Raymond C. K. Chan
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
4.Renmin Univ China, Sch Informat, Beijing, Peoples R China
5.York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada
6.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
7.Peking Univ, Yuanpei Coll, Beijing 100871, Peoples R China
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Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,et al. Neurological Soft Signs in Schizophrenia: A Meta-analysis[J]. SCHIZOPHRENIA BULLETIN,2010,36(6):1089-1104.
APA Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,Yu, Yue,Wang, Ya,&Raymond C. K. Chan.(2010).Neurological Soft Signs in Schizophrenia: A Meta-analysis.SCHIZOPHRENIA BULLETIN,36(6),1089-1104.
MLA Chan, Raymond C. K.,et al."Neurological Soft Signs in Schizophrenia: A Meta-analysis".SCHIZOPHRENIA BULLETIN 36.6(2010):1089-1104.
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