Neurological Soft Signs in Schizophrenia: A Meta-analysis

doi:10.1093/schbul/sbp011

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Neurological Soft Signs in Schizophrenia: A Meta-analysis
	Chan, Raymond C. K.1,2 ; Xu, Ting1,3,4 ; Heinrichs, R. Walter 5; Yu, Yue 1,6,7; Wang, Ya1,2 ; Raymond C. K. Chan
通讯作者邮箱	rckchan@psych.ac.cn
心理所单位排序	1
摘要	Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%-10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness.
关键词	neurological soft signs meta-analysis schizophrenia
学科领域	变态心理学
	2010-11-01
语种	英语
DOI	10.1093/schbul/sbp011
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	36 期号:6 页码:1089-1104
期刊论文类型	Article
URL	查看原文
收录类别	SCI ; SSCI
WOS记录号	WOS:000283683800007
引用统计	被引频次：142[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/10106
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Raymond C. K. Chan
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 4.Renmin Univ China, Sch Informat, Beijing, Peoples R China 5.York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada 6.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 7.Peking Univ, Yuanpei Coll, Beijing 100871, Peoples R China
第一作者单位	认知与发展心理学研究室; 中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,et al. Neurological Soft Signs in Schizophrenia: A Meta-analysis[J]. SCHIZOPHRENIA BULLETIN,2010,36(6):1089-1104.
APA	Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,Yu, Yue,Wang, Ya,&Raymond C. K. Chan.(2010).Neurological Soft Signs in Schizophrenia: A Meta-analysis.SCHIZOPHRENIA BULLETIN,36(6),1089-1104.
MLA	Chan, Raymond C. K.,et al."Neurological Soft Signs in Schizophrenia: A Meta-analysis".SCHIZOPHRENIA BULLETIN 36.6(2010):1089-1104.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Neurological%20Soft%（175KB）			开放获取	CC BY-NC-SA	浏览下载