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Neurological Soft Signs in Schizophrenia: A Meta-analysis
Chan, Raymond C. K.1,2; Xu, Ting1,3,4; Heinrichs, R. Walter5; Yu, Yue1,6,7; Wang, Ya1,2; Raymond C. K. Chan
2010-11-01
Source PublicationSCHIZOPHRENIA BULLETIN
Correspondent Emailrckchan@psych.ac.cn
ISSN0586-7614
SubtypeArticle
Volume36Issue:6Pages:1089-1104
Contribution Rank1
AbstractBackground: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%-10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness.
Keywordneurological soft signs meta-analysis schizophrenia
Subject Area变态心理学
DOI10.1093/schbul/sbp011
URL查看原文
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000283683800007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10106
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorRaymond C. K. Chan
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
4.Renmin Univ China, Sch Informat, Beijing, Peoples R China
5.York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada
6.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
7.Peking Univ, Yuanpei Coll, Beijing 100871, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,et al. Neurological Soft Signs in Schizophrenia: A Meta-analysis[J]. SCHIZOPHRENIA BULLETIN,2010,36(6):1089-1104.
APA Chan, Raymond C. K.,Xu, Ting,Heinrichs, R. Walter,Yu, Yue,Wang, Ya,&Raymond C. K. Chan.(2010).Neurological Soft Signs in Schizophrenia: A Meta-analysis.SCHIZOPHRENIA BULLETIN,36(6),1089-1104.
MLA Chan, Raymond C. K.,et al."Neurological Soft Signs in Schizophrenia: A Meta-analysis".SCHIZOPHRENIA BULLETIN 36.6(2010):1089-1104.
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