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Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
Liu, Zhenquan2; Li, Pengtao2; Zhao, Dan2; Tang, Huiling2; Guo, Jianyou1; Jianyou Guo
2010-10-19
Source PublicationBEHAVIORAL AND BRAIN FUNCTIONS
Correspondent Emailguojianyou@126.com
ISSN1744-9081
SubtypeArticle
Volume6Issue:61Pages:1-6
Contribution Rank2
AbstractBackground
Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.
Methods
The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively.
Results
Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.
Conclusions
These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.; Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.
Subject Area生理心理学/生物心理学
DOI10.1186/1744-9081-6-61
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000284111400001
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10128
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJianyou Guo
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2010,6(61):1-6.
APA Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Jianyou Guo.(2010).Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.BEHAVIORAL AND BRAIN FUNCTIONS,6(61),1-6.
MLA Liu, Zhenquan,et al."Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats".BEHAVIORAL AND BRAIN FUNCTIONS 6.61(2010):1-6.
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