Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats

doi:10.1186/1744-9081-6-61

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	Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
	Liu, Zhenquan 2; Li, Pengtao 2; Zhao, Dan 2; Tang, Huiling 2; Guo, Jianyou1 ; Jianyou Guo
通讯作者邮箱	guojianyou@126.com
心理所单位排序	2
摘要	Background Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. Methods The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Conclusions These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.; Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.
学科领域	生理心理学/生物心理学
	2010-10-19
语种	英语
DOI	10.1186/1744-9081-6-61
发表期刊	BEHAVIORAL AND BRAIN FUNCTIONS
ISSN	1744-9081
卷号	6 期号:61 页码:1-6
期刊论文类型	Article
URL	查看原文
收录类别	SCI
WOS记录号	WOS:000284111400001
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10128
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Jianyou Guo
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2010,6(61):1-6.
APA	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Jianyou Guo.(2010).Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.BEHAVIORAL AND BRAIN FUNCTIONS,6(61),1-6.
MLA	Liu, Zhenquan,et al."Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats".BEHAVIORAL AND BRAIN FUNCTIONS 6.61(2010):1-6.

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