A Connectome Computation System for discovery science of brain | |
Ting Xu; Zhi Yang; Lili Jiang; Xiu-Xia Xing; Xi-Nian Zuo | |
通讯作者邮箱 | zuoxn@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Much like genomics, brain connectomics has rapidly become a core component of most national brain projects around the world. Beyond the ambitious aims of these projects, a fundamental challenge is the need for an efficient, robust, reliable and easy-to-use pipeline to mine such large neuroscience datasets. Here, we introduce a computational pipeline—namely the Connectome Computation System (CCS)—for discovery science of human brain connectomes at the macroscale with multimodal magnetic resonance imaging technologies. The CCS is designed with a three-level hierarchical structure that includes data cleaning and preprocessing, individual connectome mapping and connectome mining, and knowledge discovery. Several functional modules are embedded into this hierarchy to implement quality control procedures, reliability analysis and connectome visualization. We demonstrate the utility of the CCS based upon a publicly available dataset, the NKI–Rockland Sample, to delineate the normative trajectories of well-known large-scale neural networks across the natural life span (6–85 years of age). The CCS has been made freely available to the public via GitHub (https://github.com/zuoxinian/CCS) and our laboratory’s Web site (http://lfcd.psych.ac.cn/ccs.html) to facilitate progress in discovery science in the field of human brain connectomics. |
关键词 | Connectome Life span Big data Normative charts Discovery science |
学科领域 | 认知神经科学 |
2015 | |
语种 | 英语 |
DOI | 10.1007/s11434-014-0698-3 |
发表期刊 | Science Bulletin |
卷号 | 60期号:1页码:86-95 |
URL | 查看原文 |
收录类别 | SCI |
资助项目 | National Basic Research Program (973) of China (2015CB351702) ; the National Natural Science Foundation of China (81220108014, 81471740, 81201153, 81171409, and 81270023) ; the Key Research Program (KSZD-EW-TZ-002) |
资助机构 | National Basic Research Program ; National Natural Science Foundation of China ; Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/10184 |
专题 | 认知与发展心理学研究室 |
通讯作者 | Xi-Nian Zuo |
推荐引用方式 GB/T 7714 | Ting Xu,Zhi Yang,Lili Jiang,et al. A Connectome Computation System for discovery science of brain[J]. Science Bulletin,2015,60(1):86-95. |
APA | Ting Xu,Zhi Yang,Lili Jiang,Xiu-Xia Xing,&Xi-Nian Zuo.(2015).A Connectome Computation System for discovery science of brain.Science Bulletin,60(1),86-95. |
MLA | Ting Xu,et al."A Connectome Computation System for discovery science of brain".Science Bulletin 60.1(2015):86-95. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A Connectome Computa(1077KB) | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 |
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