Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?

doi:10.1016/j.jpsychires.2014.11.007

	Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?
	Lui, Simon S. Y.1,2,3; Wang, Ya1 ; Yang, Tian-xiao1 ; Liu, Amy C. Y.3; Chui, William W. H.3; Yeung, Hera K. H.3; Li, Zhi 1,2; Neumann, David L.4; Shum, David H. K.4; Cheung, Eric F. C.3; Chan, Raymond C. K.1 ; Chen CQ(陈楚侨)
通讯作者邮箱	rckchan@psych.ac.cn
摘要	Prospective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that “cognitive-preserved” patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia.; Prospective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that "cognitive-preserved" patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia. (C) 2014 Elsevier Ltd. All rights reserved.
关键词	Prospective memory Schizophrenia First-episode
学科领域	医学心理学
	2015-02-01
语种	英语
DOI	10.1016/j.jpsychires.2014.11.007
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
卷号	61 期号:1 页码:141-149
期刊论文类型	Article
URL	查看原文
收录类别	SCI ; SSCI
资助项目	National Science Fund China Award (81088001 and 91132701), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), the CAS/SAFEA International Partnership Programme for Creative Research Teams (Y2CX131003), the Key Laboratory of Mental Health, Institute of Psychology, to Raymond Chan; and a grant from an Area of Strategic Investment Chronic Disease Prevention Innovation Grant (213507) to David H. K. Shum and David L. Neumann.
WOS记录号	WOS:000349731000019
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10189
专题	中国科学院心理健康重点实验室
通讯作者	Chen CQ(陈楚侨)
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Lui, Simon S. Y.,Wang, Ya,Yang, Tian-xiao,et al. Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,61(1):141-149.
APA	Lui, Simon S. Y..,Wang, Ya.,Yang, Tian-xiao.,Liu, Amy C. Y..,Chui, William W. H..,...&陈楚侨.(2015).Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?.JOURNAL OF PSYCHIATRIC RESEARCH,61(1),141-149.
MLA	Lui, Simon S. Y.,et al."Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?".JOURNAL OF PSYCHIATRIC RESEARCH 61.1(2015):141-149.

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