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Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?
Lui, Simon S. Y.1,2,3; Wang, Ya1; Yang, Tian-xiao1; Liu, Amy C. Y.3; Chui, William W. H.3; Yeung, Hera K. H.3; Li, Zhi1,2; Neumann, David L.4; Shum, David H. K.4; Cheung, Eric F. C.3; Chan, Raymond C. K.1; Chen CQ(陈楚侨)
2015-02-01
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
Correspondent Emailrckchan@psych.ac.cn
ISSN0022-3956
SubtypeArticle
Volume61Issue:1Pages:141-149
AbstractProspective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that “cognitive-preserved” patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia.; Prospective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that "cognitive-preserved" patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordProspective memory Schizophrenia First-episode
Subject Area医学心理学
DOI10.1016/j.jpsychires.2014.11.007
URL查看原文
Indexed BySCI ; SSCI
Language英语
Funding ProjectNational Science Fund China Award (81088001 and 91132701), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), the CAS/SAFEA International Partnership Programme for Creative Research Teams (Y2CX131003), the Key Laboratory of Mental Health, Institute of Psychology, to Raymond Chan; and a grant from an Area of Strategic Investment Chronic Disease Prevention Innovation Grant (213507) to David H. K. Shum and David L. Neumann.
WOS IDWOS:000349731000019
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10189
Collection中国科学院心理健康重点实验室
Corresponding AuthorChen CQ(陈楚侨)
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia
Recommended Citation
GB/T 7714
Lui, Simon S. Y.,Wang, Ya,Yang, Tian-xiao,et al. Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,61(1):141-149.
APA Lui, Simon S. Y..,Wang, Ya.,Yang, Tian-xiao.,Liu, Amy C. Y..,Chui, William W. H..,...&陈楚侨.(2015).Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?.JOURNAL OF PSYCHIATRIC RESEARCH,61(1),141-149.
MLA Lui, Simon S. Y.,et al."Problems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?".JOURNAL OF PSYCHIATRIC RESEARCH 61.1(2015):141-149.
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