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Post-stroke depression and lesion location: a systematic review
Wei, Na1; Yong, Wu2; Li, Xinyan1; Zhou, Yafan1; Deng, Manfei1; Zhu, Houze1; Jin, Huijuan1; Huijuan Jin
2015
Source PublicationJOURNAL OF NEUROLOGY
ISSN0340-5354
SubtypeReview
Volume262Issue:1Pages:81-90
Contribution Rank2
AbstractPost-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran’s Q test and I 2 test. Begg’s funnel plot and Egger’s test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88–1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1–6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66–0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.; Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran's Q test and I (2) test. Begg's funnel plot and Egger's test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88-1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1-6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66-0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.
KeywordPost-stroke depression Lesion location Meta-analysis
Subject Area变态心理学
DOI10.1007/s00415-014-7534-1
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Fund of Hubei Province ; China Postdoctoral Science Foundation
Funding ProjectNational Natural Science Foundation of China(81301165 ) ; Natural Science Fund of Hubei Province (2012FFB03706 ) ; China Postdoctoral Science Foundation (2014M552047 )
WOS IDWOS:000348216000010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10203
Collection管理系统
Corresponding AuthorHuijuan Jin
Affiliation1.Huazhong Univ Sci & Technol, Inst Brain Res, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing 100015, Peoples R China
Recommended Citation
GB/T 7714
Wei, Na,Yong, Wu,Li, Xinyan,et al. Post-stroke depression and lesion location: a systematic review[J]. JOURNAL OF NEUROLOGY,2015,262(1):81-90.
APA Wei, Na.,Yong, Wu.,Li, Xinyan.,Zhou, Yafan.,Deng, Manfei.,...&Huijuan Jin.(2015).Post-stroke depression and lesion location: a systematic review.JOURNAL OF NEUROLOGY,262(1),81-90.
MLA Wei, Na,et al."Post-stroke depression and lesion location: a systematic review".JOURNAL OF NEUROLOGY 262.1(2015):81-90.
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