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| A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23 | |
Li, Yongzhe1,2; Zhang, Kunlin3 ; Chen, Hua1,2; Sun, Fei1,2; Xu, Juanjuan1,2; Wu, Ziyan1,2; Li, Ping1,2; Zhang, Liuyan3; Du, Yang3; Luan, Haixia1,2; Li, Xi1,2; Wu, Lijun4; Li, Hongbin5; Wu, Huaxiang6; Li, Xiangpei7; Li, Xiaomei7; Zhang, Xiao8; Gong, Lu9; Dai, Lie10; Sun, Lingyun11; Zuo, Xiaoxia12; Xu, Jianhua13; Gong, Huiping14; Li, Zhijun15; Tong, Shengquan16; Wu, Min17; Li, Xiaofeng18; Xiao, Weiguo19; Wang, Guochun20; Zhu, Ping21; Shen, Min1,2; Liu, Shengyun22; Zhao, Dongbao23; Liu, Wei24; Wang, Yi25; Huang, Cibo26; Jiang, Quan27; Liu, Guijian28; Liu, Bin29; Hu, Shaoxian30; Zhang, Wen1,2; Zhang, Zhuoli31; You, Xin1,2; Li, Mengtao1,2; Hao, Weixin32,33; Zhao, Cheng34; Leng, Xiaomei1,2; Bi, Liqi35; Wang, Yongfu36; Zhang, Fengxiao37; Shi, Qun1,2; Qi, Wencheng38; Zhang, Xuewu39; Jia, Yuan39; Su, Jinmei1,2; Li, Qin40; Hou, Yong1,2; Wu, Qingjun1,2; Xu, Dong1,2; Zheng, Wenjie1,2; Zhang, Miaojia41; Wang, Qian1,2; Fei, Yunyun1,2; Zhang, Xuan1,2; Li, Jing1,2; Jiang, Ying1,2; Tian, Xinping1,2; Zhao, Lidan1,2; Wang, Li1,2; Zhou, Bin42,43; Li, Yang44; Zhao, Yan1,2; Zeng, Xiaofeng1,2; Ott, Jurg3; Wang, Jing3; Zhang, Fengchun1,2
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| 摘要 | Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P-combined = 1.31 x 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. |
| 2013-11-01 | |
| 语种 | 英语 |
| 发表期刊 | NATURE GENETICS
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| 卷号 | 45期号:11页码:1361-+ |
| 收录类别 | SCI |
| WOS记录号 | WOS:000326384100017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/10620 |
| 专题 | 中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China 2.Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Peoples R China 5.Inner Mongolia Med Coll, Affiliated Hosp, Dept Rheumatol, Hohhot, Peoples R China 6.Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Rheumatol, Hangzhou 310027, Zhejiang, Peoples R China 7.Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Rheumatol & Immun, Hefei, Peoples R China 8.Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China 9.Tianjin Med Univ, Gen Hosp, Dept Immunol, Tianjin, Peoples R China 10.Sun Yat Sen Univ, SUN Yat Sen Mem Hosp, Dept Rheumatol, Guangzhou 510275, Guangdong, Peoples R China 11.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China 12.Cent S Univ, Xiangya Hosp, Dept Rheumatol & Immunol, Changsha 410083, Peoples R China 13.Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol, Hefei, Peoples R China 14.Changzhi Med Coll, Affiliated Heping Hosp, Dept Rheumatol & Immunol, Changzhi, Peoples R China 15.Bengbu Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Bengbu, Peoples R China 16.Tangshan Gongren Hosp, Dept Rheumatol & Immunol, Tangshan, Peoples R China 17.First Peoples Hosp Changzhou, Dept Rheumatol & Immunol, Changzhou, Peoples R China 18.Shanxi Med Univ Second Hosp, Dept Rheumatol & Immunol, Taiyuan, Peoples R China 19.China Med Univ, Hosp 1, Dept Rheumatol, Shenyang, Peoples R China 20.China Japan Friendship Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China 21.Fourth Mil Med Univ, Xijing Hosp, Dept Rheumatol & Immunol, Xian 710032, Peoples R China 22.Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou 450052, Peoples R China 23.Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai, Peoples R China 24.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Rheumatol & Immunol, Tianjin, Peoples R China 25.Lanzhou Univ, Hosp 2, Dept Rheumatol & Immunol, Lanzhou 730000, Peoples R China 26.Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China 27.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol, Beijing, Peoples R China 28.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Lab, Beijing, Peoples R China 29.Qingdao Univ, Affiliated Hosp, Coll Med, Dept Rheumatol & Immunol, Qingdao 266071, Peoples R China 30.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Immunol & Rheumatol, Wuhan 430074, Peoples R China 31.Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China 32.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Tradit Chinese Med, Beijing 100021, Peoples R China 33.Chinese Acad Med Sci, Beijing 100730, Peoples R China 34.Guangxi Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Nanning, Peoples R China 35.Jilin Univ, China Japan Union Hosp, Dept Rheumatol & Immunol, Changchun 130023, Peoples R China 36.Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Baotou, Peoples R China 37.Hebei Peoples Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Peoples R China 38.Tianjin First Cent Hosp, Dept Rheumatol & Immunol, Tianjin, Peoples R China 39.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China 40.Yunnan Univ, Peoples Hosp 1, Dept Rheumatol & Immunol, Kunming, Peoples R China 41.Jiangsu Prov Peoples Hosp, Dept Rheumatol, Nanjing, Jiangsu, Peoples R China 42.Sichuan Acad Med Sci, Dept Rheumatol & Immunol, Chengdu, Peoples R China 43.Sichuan Prov Peoples Hosp, Chengdu, Peoples R China 44.Harbin Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Harbin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongzhe,Zhang, Kunlin,Chen, Hua,et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23[J]. NATURE GENETICS,2013,45(11):1361-+. |
| APA | Li, Yongzhe.,Zhang, Kunlin.,Chen, Hua.,Sun, Fei.,Xu, Juanjuan.,...&Zhang, Fengchun.(2013).A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23.NATURE GENETICS,45(11),1361-+. |
| MLA | Li, Yongzhe,et al."A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23".NATURE GENETICS 45.11(2013):1361-+. |
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