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A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23
Li, Yongzhe1,2; Zhang, Kunlin3; Chen, Hua1,2; Sun, Fei1,2; Xu, Juanjuan1,2; Wu, Ziyan1,2; Li, Ping1,2; Zhang, Liuyan3; Du, Yang3; Luan, Haixia1,2; Li, Xi1,2; Wu, Lijun4; Li, Hongbin5; Wu, Huaxiang6; Li, Xiangpei7; Li, Xiaomei7; Zhang, Xiao8; Gong, Lu9; Dai, Lie10; Sun, Lingyun11; Zuo, Xiaoxia12; Xu, Jianhua13; Gong, Huiping14; Li, Zhijun15; Tong, Shengquan16; Wu, Min17; Li, Xiaofeng18; Xiao, Weiguo19; Wang, Guochun20; Zhu, Ping21; Shen, Min1,2; Liu, Shengyun22; Zhao, Dongbao23; Liu, Wei24; Wang, Yi25; Huang, Cibo26; Jiang, Quan27; Liu, Guijian28; Liu, Bin29; Hu, Shaoxian30; Zhang, Wen1,2; Zhang, Zhuoli31; You, Xin1,2; Li, Mengtao1,2; Hao, Weixin32,33; Zhao, Cheng34; Leng, Xiaomei1,2; Bi, Liqi35; Wang, Yongfu36; Zhang, Fengxiao37; Shi, Qun1,2; Qi, Wencheng38; Zhang, Xuewu39; Jia, Yuan39; Su, Jinmei1,2; Li, Qin40; Hou, Yong1,2; Wu, Qingjun1,2; Xu, Dong1,2; Zheng, Wenjie1,2; Zhang, Miaojia41; Wang, Qian1,2; Fei, Yunyun1,2; Zhang, Xuan1,2; Li, Jing1,2; Jiang, Ying1,2; Tian, Xinping1,2; Zhao, Lidan1,2; Wang, Li1,2; Zhou, Bin42,43; Li, Yang44; Zhao, Yan1,2; Zeng, Xiaofeng1,2; Ott, Jurg3; Wang, Jing3; Zhang, Fengchun1,2
2013-11-01
Source PublicationNATURE GENETICS
Volume45Issue:11Pages:1361-+
AbstractPrimary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P-combined = 1.31 x 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I.
Indexed BySCI
Language英语
WOS IDWOS:000326384100017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10620
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Peoples R China
5.Inner Mongolia Med Coll, Affiliated Hosp, Dept Rheumatol, Hohhot, Peoples R China
6.Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Rheumatol, Hangzhou 310027, Zhejiang, Peoples R China
7.Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Rheumatol & Immun, Hefei, Peoples R China
8.Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China
9.Tianjin Med Univ, Gen Hosp, Dept Immunol, Tianjin, Peoples R China
10.Sun Yat Sen Univ, SUN Yat Sen Mem Hosp, Dept Rheumatol, Guangzhou 510275, Guangdong, Peoples R China
11.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Rheumatol & Immunol, Nanjing 210008, Jiangsu, Peoples R China
12.Cent S Univ, Xiangya Hosp, Dept Rheumatol & Immunol, Changsha 410083, Peoples R China
13.Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol, Hefei, Peoples R China
14.Changzhi Med Coll, Affiliated Heping Hosp, Dept Rheumatol & Immunol, Changzhi, Peoples R China
15.Bengbu Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Bengbu, Peoples R China
16.Tangshan Gongren Hosp, Dept Rheumatol & Immunol, Tangshan, Peoples R China
17.First Peoples Hosp Changzhou, Dept Rheumatol & Immunol, Changzhou, Peoples R China
18.Shanxi Med Univ Second Hosp, Dept Rheumatol & Immunol, Taiyuan, Peoples R China
19.China Med Univ, Hosp 1, Dept Rheumatol, Shenyang, Peoples R China
20.China Japan Friendship Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
21.Fourth Mil Med Univ, Xijing Hosp, Dept Rheumatol & Immunol, Xian 710032, Peoples R China
22.Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou 450052, Peoples R China
23.Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai, Peoples R China
24.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Rheumatol & Immunol, Tianjin, Peoples R China
25.Lanzhou Univ, Hosp 2, Dept Rheumatol & Immunol, Lanzhou 730000, Peoples R China
26.Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China
27.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol, Beijing, Peoples R China
28.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Lab, Beijing, Peoples R China
29.Qingdao Univ, Affiliated Hosp, Coll Med, Dept Rheumatol & Immunol, Qingdao 266071, Peoples R China
30.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Immunol & Rheumatol, Wuhan 430074, Peoples R China
31.Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
32.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Tradit Chinese Med, Beijing 100021, Peoples R China
33.Chinese Acad Med Sci, Beijing 100730, Peoples R China
34.Guangxi Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Nanning, Peoples R China
35.Jilin Univ, China Japan Union Hosp, Dept Rheumatol & Immunol, Changchun 130023, Peoples R China
36.Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Baotou, Peoples R China
37.Hebei Peoples Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Peoples R China
38.Tianjin First Cent Hosp, Dept Rheumatol & Immunol, Tianjin, Peoples R China
39.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
40.Yunnan Univ, Peoples Hosp 1, Dept Rheumatol & Immunol, Kunming, Peoples R China
41.Jiangsu Prov Peoples Hosp, Dept Rheumatol, Nanjing, Jiangsu, Peoples R China
42.Sichuan Acad Med Sci, Dept Rheumatol & Immunol, Chengdu, Peoples R China
43.Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
44.Harbin Med Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Harbin, Peoples R China
Recommended Citation
GB/T 7714
Li, Yongzhe,Zhang, Kunlin,Chen, Hua,et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23[J]. NATURE GENETICS,2013,45(11):1361-+.
APA Li, Yongzhe.,Zhang, Kunlin.,Chen, Hua.,Sun, Fei.,Xu, Juanjuan.,...&Zhang, Fengchun.(2013).A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23.NATURE GENETICS,45(11),1361-+.
MLA Li, Yongzhe,et al."A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23".NATURE GENETICS 45.11(2013):1361-+.
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