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Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia
Lam, Joanna W. S.1; Lui, Simon S. Y.1,2,3; Wang, Ya2,3; Chan, Raymond C. K.2,3; Cheung, Eric F. C.1; Cheung, EFC (reprint author), Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China.
2013
发表期刊SCHIZOPHRENIA RESEARCH
ISSN0586-7614
文章类型期刊论文
卷号147期号:2014-02-03页码:293-300
产权排序2
摘要Background: Prospective memory (PM), the ability to remember to carry out an intended action in the future, is thought to relate closely to everyday functioning, such as medication adherence. PM impairment in schizophrenia may contribute to unintentional medication non-adherence. This study aimed to examine the relationship between PM, medication management and medication adherence. Methods: Eighty-two stable patients with schizophrenia underwent assessment for PM and medication management ability by laboratory measures at baseline. Clinical symptoms, other neuropsychological functions and risk factors known to associate with non-adherence were also measured. Linear regression was used to identify predictors of medication management ability at baseline. Actual medication adherence was assessed three months later and logistic regression was used to identify predictors of non-adherence. Results: In the linear regression model, time-and event-based PM together accounted for 72.3% of the variance in the performance of medication management at baseline. At three-month follow-up, the non-adherent group performed significantly more poorly in time-and event-based PM, and had poorer insight, more severe symptoms and poorer ability to manage medications, as compared to the adherent group. In the logistic regression model, insight and PANSS general score significantly predicted non-adherence in the community. Time- and event-based PM moderated the predictive power of insight and PANSS general score. Conclusions: Our results support that PM performance robustly predicts medication management ability and may influence medication adherence in the community by moderating the effect of insight and symptom severity. Optimizing PM performance may improve medication adherence in the community, particularly for unintentional non-adherence. (C) 2013 Elsevier B. V. All rights reserved.
关键词Schizophrenia Prospective memory Medication management Treatment adherence
学科领域Abnormal Psychology
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收录类别SCI
语种英语
项目资助者Key Laboratory of Mental Health, Institute of Psychology ; Chinese Academy of Sciences [KSCX2-EW-J-8]
项目简介This study was supported partially by grants from the Key Laboratory of Mental Health, Institute of Psychology, and the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8). These funding agents had no further role in the study design; in the collection, analysis and interpretation of the data; in the writing of the manuscript; and in the decision to submit the paper for publication.
WOS记录号WOS:000320598700013
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10621
专题脑与认知科学国家重点实验室
通讯作者Cheung, EFC (reprint author), Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China.
作者单位1.Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Lam, Joanna W. S.,Lui, Simon S. Y.,Wang, Ya,et al. Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,147(2014-02-03):293-300.
APA Lam, Joanna W. S.,Lui, Simon S. Y.,Wang, Ya,Chan, Raymond C. K.,Cheung, Eric F. C.,&Cheung, EFC .(2013).Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia.SCHIZOPHRENIA RESEARCH,147(2014-02-03),293-300.
MLA Lam, Joanna W. S.,et al."Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia".SCHIZOPHRENIA RESEARCH 147.2014-02-03(2013):293-300.
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