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Aging-associated excess formaldehyde leads to spatial memory deficits
Tong, Zhiqian1,5; Han, Chanshuai1,4; Luo, Wenhong2; Li, Hui2; Luo, Hongjun2; Qiang, Min1,4; Su, Tao1,4; Wu, Beibei1,4; Liu, Ying1; Yang, Xu3; Wan, You5; Cui, Dehua5; He, Rongqiao1,6
AbstractRecent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies that neuronal activity induces global DNA demethylation and re-methylation; and DNA methylation is a critical step for memory formation. These data suggest that endogenous formaldehyde may intrinsically link learning-responsive DNA methylation status and memory formation. Here, we report that during spatial memory formation process, spatial training induces an initial global DNA demethylation and subsequent re-methylation associated with hippocampal formaldehyde elevation then decline to baseline level in Sprague Dawley rats. Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats. Furthermore, we found that the normal adult rats intrahippocampally injected with excess formaldehyde can imitate the aged-related spatial memory deficits and global DNA methylation decline. These findings indicate that aging-associated excess formaldheyde contributes to cognitive decline during aging.
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WOS IDWOS:000318572400002
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China
3.Huazhong Normal Univ, Lab Environm Sci, Wuhan 430079, Peoples R China
4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China
5.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Aging-associated excess formaldehyde leads to spatial memory deficits[J]. SCIENTIFIC REPORTS,2013,3.
APA Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Li, Hui.,Luo, Hongjun.,...&He, Rongqiao.(2013).Aging-associated excess formaldehyde leads to spatial memory deficits.SCIENTIFIC REPORTS,3.
MLA Tong, Zhiqian,et al."Aging-associated excess formaldehyde leads to spatial memory deficits".SCIENTIFIC REPORTS 3(2013).
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