Aging-associated excess formaldehyde leads to spatial memory deficits

	Aging-associated excess formaldehyde leads to spatial memory deficits
	Tong, Zhiqian 1,5; Han, Chanshuai 1,4; Luo, Wenhong 2; Li, Hui 2; Luo, Hongjun 2; Qiang, Min 1,4; Su, Tao 1,4; Wu, Beibei 1,4; Liu, Ying1 ; Yang, Xu 3; Wan, You 5; Cui, Dehua 5; He, Rongqiao 1,6
摘要	Recent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies that neuronal activity induces global DNA demethylation and re-methylation; and DNA methylation is a critical step for memory formation. These data suggest that endogenous formaldehyde may intrinsically link learning-responsive DNA methylation status and memory formation. Here, we report that during spatial memory formation process, spatial training induces an initial global DNA demethylation and subsequent re-methylation associated with hippocampal formaldehyde elevation then decline to baseline level in Sprague Dawley rats. Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats. Furthermore, we found that the normal adult rats intrahippocampally injected with excess formaldehyde can imitate the aged-related spatial memory deficits and global DNA methylation decline. These findings indicate that aging-associated excess formaldheyde contributes to cognitive decline during aging.
	2013-05-09
语种	英语
发表期刊	SCIENTIFIC REPORTS
卷号	3
收录类别	SCI
WOS记录号	WOS:000318572400002
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10627
专题	脑与认知科学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China 3.Huazhong Normal Univ, Lab Environm Sci, Wuhan 430079, Peoples R China 4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China 5.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	脑与认知科学国家重点实验室
推荐引用方式 GB/T 7714	Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Aging-associated excess formaldehyde leads to spatial memory deficits[J]. SCIENTIFIC REPORTS,2013,3.
APA	Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Li, Hui.,Luo, Hongjun.,...&He, Rongqiao.(2013).Aging-associated excess formaldehyde leads to spatial memory deficits.SCIENTIFIC REPORTS,3.
MLA	Tong, Zhiqian,et al."Aging-associated excess formaldehyde leads to spatial memory deficits".SCIENTIFIC REPORTS 3(2013).

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