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The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
Zhang, Wei-Na; Chang, Su-Hua; Guo, Li-Yuan; Zhang, Kun-Lin; Wang, Jing; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2013
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN1075-5535
Subtype期刊论文
Volume151Issue:2Pages:531-539
Contribution Rank1
AbstractBackground: A growing number of functional magnetic resonance imaging (fMRI) studies have been conducted in major depressive disorder (MDD) to elucidate reward-related brain functions. The aim of this meta-analysis was to examine the common reward network in the MDD brain and to further distinguish the brain activation patterns between positive stimuli and monetary rewards as well as reward anticipation and outcome. Methods: A series of activation likelihood estimation (ALE) meta-analyses were performed across 22 fMRI studies that examined reward-related processing, with a total of 341 MDD patients and 367 healthy controls. Results: We observed several frontostriatal regions that participated in reward processing in MDD. The common reward network in MDD was characterized by decreased subcortical and limbic areas activity and an increased cortical response. In addition, the cerebellum, lingual gyms, parahippocampal gyrus and fusiform gyrus preferentially responded to positive stimuli in MDD, while the insula, precuneus, cuneus, PFC and inferior parietal lobule selectively responded to monetary rewards. Our results indicated a reduced caudate response during both monetary anticipation and outcome stages as well as increased activation in the middle frontal gyrus and dorsal anterior cingulate during reward anticipation in MDD. Limitations: The reward-related tasks and mood states of patients included in our analysis were heterogeneous. Conclusions: Our current findings suggest that there exist emotional or motivational pathway dysfunctions in MDD during reward-related processing. Future studies may be strengthened by paying careful attention to the types of reward used as well as the different components of reward processing examined. (C) 2013 Elsevier B.V. All rights reserved.
KeywordReward Major depressive disorder Meta-analysis fMRI
Subject AreaPhysiological Psychology/biological Psychology,Health Psychology
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Indexed BySSCI
Language英语
Funding OrganizationKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Chinese Academy of Sciences [KSCX2-EW-J-8] ; CAS/SAFEA [Y2CX131003] ; National Natural Science Foundation of China [81201046]
Project Intro.This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8). This work was also supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (Y2CX131003) and National Natural Science Foundation of China (81201046).
WOS IDWOS:000325432900017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10630
Collection中国科学院行为科学重点实验室
Corresponding AuthorWang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
AffiliationWang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Wei-Na,Chang, Su-Hua,Guo, Li-Yuan,et al. The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,151(2):531-539.
APA Zhang, Wei-Na,Chang, Su-Hua,Guo, Li-Yuan,Zhang, Kun-Lin,Wang, Jing,&Wang, J .(2013).The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies.JOURNAL OF AFFECTIVE DISORDERS,151(2),531-539.
MLA Zhang, Wei-Na,et al."The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies".JOURNAL OF AFFECTIVE DISORDERS 151.2(2013):531-539.
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