The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies

	The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
	Zhang, Wei-Na; Chang, Su-Hua; Guo, Li-Yuan; Zhang, Kun-Lin; Wang, Jing; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Background: A growing number of functional magnetic resonance imaging (fMRI) studies have been conducted in major depressive disorder (MDD) to elucidate reward-related brain functions. The aim of this meta-analysis was to examine the common reward network in the MDD brain and to further distinguish the brain activation patterns between positive stimuli and monetary rewards as well as reward anticipation and outcome. Methods: A series of activation likelihood estimation (ALE) meta-analyses were performed across 22 fMRI studies that examined reward-related processing, with a total of 341 MDD patients and 367 healthy controls. Results: We observed several frontostriatal regions that participated in reward processing in MDD. The common reward network in MDD was characterized by decreased subcortical and limbic areas activity and an increased cortical response. In addition, the cerebellum, lingual gyms, parahippocampal gyrus and fusiform gyrus preferentially responded to positive stimuli in MDD, while the insula, precuneus, cuneus, PFC and inferior parietal lobule selectively responded to monetary rewards. Our results indicated a reduced caudate response during both monetary anticipation and outcome stages as well as increased activation in the middle frontal gyrus and dorsal anterior cingulate during reward anticipation in MDD. Limitations: The reward-related tasks and mood states of patients included in our analysis were heterogeneous. Conclusions: Our current findings suggest that there exist emotional or motivational pathway dysfunctions in MDD during reward-related processing. Future studies may be strengthened by paying careful attention to the types of reward used as well as the different components of reward processing examined. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Reward Major depressive disorder Meta-analysis fMRI
学科领域	Physiological Psychology/biological Psychology,Health Psychology
	2013
语种	英语
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	1075-5535
卷号	151 期号:2 页码:531-539
期刊论文类型	期刊论文
URL	查看原文
收录类别	SSCI
项目简介	This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8). This work was also supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (Y2CX131003) and National Natural Science Foundation of China (81201046).
WOS记录号	WOS:000325432900017
资助机构	Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Chinese Academy of Sciences [KSCX2-EW-J-8] ; CAS/SAFEA [Y2CX131003] ; National Natural Science Foundation of China [81201046]
引用统计	被引频次：248[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10630
专题	中国科学院行为科学重点实验室
通讯作者	Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Wei-Na,Chang, Su-Hua,Guo, Li-Yuan,et al. The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,151(2):531-539.
APA	Zhang, Wei-Na,Chang, Su-Hua,Guo, Li-Yuan,Zhang, Kun-Lin,Wang, Jing,&Wang, J .(2013).The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies.JOURNAL OF AFFECTIVE DISORDERS,151(2),531-539.
MLA	Zhang, Wei-Na,et al."The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies".JOURNAL OF AFFECTIVE DISORDERS 151.2(2013):531-539.

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