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Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats
Li, Chun-Lu1,2; Zhu, Ning1; Meng, Xiao-Lu1,2; Li, Yong-Hui1; Sui, Nan1; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊JOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
文章类型期刊论文
卷号27期号:9页码:837-844
产权排序1
摘要Recent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context remains unclear. To elucidate the organization of opiate-related affective learning within the insular cortex, we reversibly inactivated each of two major subdivisions of the insula in rats and tested the effects of this inactivation on the acquisition of morphine-induced conditioned place preference (CPP) and conditioned place aversion (CPA) induced by naloxone-precipitated acute morphine withdrawal. Results showed that inactivation of the primary interoceptive posterior granular insula (GI), but not that of the high-order anterior agranular insula (AI), disrupted the acquisition of CPP and that both GI and AI inactivation impaired the acquisition of CPA. These data suggest that the insular cortex is involved in positive and negative affective learning related to opiate addiction. In particular, the GI appears to be critical for both forms of affective learning, whereas the AI is crucial for learning associated with negative affects induced by opiate withdrawal.
关键词Morphine naloxone agranular granular insular cortex conditioned place preference conditioned place aversion
学科领域Physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者Chinese Academy of Sciences [KSCX2-EW-R-12] ; National Basic Research Program [2009CB522002] ; National Natural Science Foundation [31170988, 31200770] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介The study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000323644300009
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10634
专题中国科学院心理健康重点实验室
通讯作者Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,et al. Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(9):837-844.
APA Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,Li, Yong-Hui,Sui, Nan,&Sui, N .(2013).Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(9),837-844.
MLA Li, Chun-Lu,et al."Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.9(2013):837-844.
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