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Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats
Li, Chun-Lu1,2; Zhu, Ning1; Meng, Xiao-Lu1,2; Li, Yong-Hui1; Sui, Nan1; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
Subtype期刊论文
Volume27Issue:9Pages:837-844
Contribution Rank1
AbstractRecent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context remains unclear. To elucidate the organization of opiate-related affective learning within the insular cortex, we reversibly inactivated each of two major subdivisions of the insula in rats and tested the effects of this inactivation on the acquisition of morphine-induced conditioned place preference (CPP) and conditioned place aversion (CPA) induced by naloxone-precipitated acute morphine withdrawal. Results showed that inactivation of the primary interoceptive posterior granular insula (GI), but not that of the high-order anterior agranular insula (AI), disrupted the acquisition of CPP and that both GI and AI inactivation impaired the acquisition of CPA. These data suggest that the insular cortex is involved in positive and negative affective learning related to opiate addiction. In particular, the GI appears to be critical for both forms of affective learning, whereas the AI is crucial for learning associated with negative affects induced by opiate withdrawal.
KeywordMorphine naloxone agranular granular insular cortex conditioned place preference conditioned place aversion
Subject AreaPhysiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationChinese Academy of Sciences [KSCX2-EW-R-12] ; National Basic Research Program [2009CB522002] ; National Natural Science Foundation [31170988, 31200770] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.The study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS IDWOS:000323644300009
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10634
Collection中国科学院心理健康重点实验室
Corresponding AuthorSui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,et al. Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(9):837-844.
APA Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,Li, Yong-Hui,Sui, Nan,&Sui, N .(2013).Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(9),837-844.
MLA Li, Chun-Lu,et al."Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.9(2013):837-844.
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