中国科学院心理研究所机构知识库

Background. Prospective memory (PM) refers to the ability to remember to carry out an intended action in the future. PM is consistently found to be impaired in individuals with schizophrenia. Bipolar disorder and schizophrenia may represent conditions along a continuum, and share similar neurocognitive and genetic architecture. This study aimed to compare the nature and extent of PM impairment in individuals with schizophrenia and bipolar disorder. Method. Participants were 38 out-patients with schizophrenia and 40 out-patients with bipolar disorder in an early psychosis intervention programme, and 37 healthy controls. Time-, event-and activity-based PMs were assessed using a dual-task laboratory paradigm. Self-reported PM performance was gauged using the Prospective and Retrospective Memory Questionnaire. Analysis of covariance (ANCOVA), with intelligence quotient (IQ) and education included as covariates, was used to examine group difference on various types of PM. Repeated measures of ANCOVA were used to examine the group x PM type interaction effect. Correspondence between laboratory and self-reported PM measures was examined using correlational analysis. Results. The group x PM type interaction effect was not significant, but the main effect of group was significant. Patients with schizophrenia and patients with bipolar disorder both performed more poorly than healthy participants in PM. The two clinical groups did not significantly differ in PM. Laboratory and self-reported PM measures did not correlate significantly with each other. Conclusions. Patients with bipolar disorder shared a similar PM impairment with those with schizophrenia. Findings of this study extended the similarity in neurocognitive impairments between the two psychiatric disorders to PM.

This study was supported partially by grants from the National Science Fund China (no. 81088001 and 91132701), a grant from the Knowledge Innovation Project of the Chinese Academy of Sciences (no. KSCX2-EW-J-8), the initiation fund of the China Academy of Sciences and State Administration of Foreign Experts Affairs of the People's Republic of China (CAS/SAFEA, Y2CX131003) International Partnership Program for Creative Research Teams, and the Smart Futures Fund (QLD), National and International Research Alliances Programme.