Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear

	Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear
	Zheng, Xigeng1 ; Deschaux, Olivier 2,3,4; Lavigne, Jennifer 4; Nachon, Ophelie 2,3; Cleren, Carine 5; Moreau, Jean-Luc 6; Garcia, Rene 2,3,4; Garcia, R (reprint author), Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France.
心理所单位排序	1
摘要	We have recently shown that post-extinction exposure of rats to a sub-conditioning procedure (SCP, i.e. retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) or to acute stress provokes reemergence of extinguished fear. Furthermore, this SCP effect can be abolished by high-frequency stimulation (HFS) of the medial prefrontal cortex (mPFC), when applied following the SCP. The aim of the present study was to test whether HFS of the mPK is effective in preventing both SCP-induced and acute stress-provoked fear reemergence. Rats implanted with stimulating electrodes in the mPFC were trained to acquire high levels of freezing to conditioned auditory cue. This fear response was then extinguished. Three weeks later, no spontaneous recovery was observed, but rats exposed to either the SCP or acute stress again exhibited high levels of freezing. HFS of the mPFC, applied before provoking fear reemergence, prevented the effects of SCP, but not acute stress. These data suggest that acute stress may have more impact on functions of the mPFC and/or associated structures than a situational reminder of fear conditioning. (C) 2013 Elsevier Inc. All rights reserved.
关键词	Conditioned freezing Fear extinction and return Prefrontal electrical stimulation Medial prefrontal cortex Rats
学科领域	Cognitive Neuroscience
	2013
语种	英语
发表期刊	NEUROBIOLOGY OF LEARNING AND MEMORY
ISSN	1074-7427
卷号	101 页码:33-38
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was supported by University of Nice-Sophia Antipolis (O.D., J.L., O.N., C.C., R.G.), F. Hoffmann-La Roche (J.L.M), and The Chinese Academy of Science The Chinese Academy of Sciences-Key Laboratory of Mental Health, IPCAS (30971057/KSCX2-EW-J-8 to X.Z.). We thank Dr. D Finn for his critical review of this manuscript.
WOS记录号	WOS:000317088700005
资助机构	University of Nice-Sophia Antipolis ; F. Hoffmann-La Roche ; Chinese Academy of Science The Chinese Academy of Sciences-Key Laboratory of Mental Health, IPCAS [30971057/KSCX2-EW-J-8]
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10639
专题	中国科学院心理健康重点实验室
通讯作者	Garcia, R (reprint author), Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Aix Marseille Univ, Inst Neurosci Timone, UMR7289, F-13385 Marseille, France 3.CNRS, F-13385 Marseille, France 4.Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France 5.Univ Rouen, Lab Neovasc, ERI 28, F-76183 Rouen, France 6.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zheng, Xigeng,Deschaux, Olivier,Lavigne, Jennifer,et al. Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,101:33-38.
APA	Zheng, Xigeng.,Deschaux, Olivier.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Garcia, R .(2013).Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear.NEUROBIOLOGY OF LEARNING AND MEMORY,101,33-38.
MLA	Zheng, Xigeng,et al."Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear".NEUROBIOLOGY OF LEARNING AND MEMORY 101(2013):33-38.

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