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Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear
Zheng, Xigeng1; Deschaux, Olivier2,3,4; Lavigne, Jennifer4; Nachon, Ophelie2,3; Cleren, Carine5; Moreau, Jean-Luc6; Garcia, Rene2,3,4; Garcia, R (reprint author), Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France.
2013
Source PublicationNEUROBIOLOGY OF LEARNING AND MEMORY
ISSN1074-7427
Subtype期刊论文
Volume101Pages:33-38
Contribution Rank1
AbstractWe have recently shown that post-extinction exposure of rats to a sub-conditioning procedure (SCP, i.e. retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) or to acute stress provokes reemergence of extinguished fear. Furthermore, this SCP effect can be abolished by high-frequency stimulation (HFS) of the medial prefrontal cortex (mPFC), when applied following the SCP. The aim of the present study was to test whether HFS of the mPK is effective in preventing both SCP-induced and acute stress-provoked fear reemergence. Rats implanted with stimulating electrodes in the mPFC were trained to acquire high levels of freezing to conditioned auditory cue. This fear response was then extinguished. Three weeks later, no spontaneous recovery was observed, but rats exposed to either the SCP or acute stress again exhibited high levels of freezing. HFS of the mPFC, applied before provoking fear reemergence, prevented the effects of SCP, but not acute stress. These data suggest that acute stress may have more impact on functions of the mPFC and/or associated structures than a situational reminder of fear conditioning. (C) 2013 Elsevier Inc. All rights reserved.
KeywordConditioned freezing Fear extinction and return Prefrontal electrical stimulation Medial prefrontal cortex Rats
Subject AreaCognitive Neuroscience
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Indexed BySCI
Language英语
Funding OrganizationUniversity of Nice-Sophia Antipolis ; F. Hoffmann-La Roche ; Chinese Academy of Science The Chinese Academy of Sciences-Key Laboratory of Mental Health, IPCAS [30971057/KSCX2-EW-J-8]
Project Intro.This study was supported by University of Nice-Sophia Antipolis (O.D., J.L., O.N., C.C., R.G.), F. Hoffmann-La Roche (J.L.M), and The Chinese Academy of Science The Chinese Academy of Sciences-Key Laboratory of Mental Health, IPCAS (30971057/KSCX2-EW-J-8 to X.Z.). We thank Dr. D Finn for his critical review of this manuscript.
WOS IDWOS:000317088700005
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10639
Collection中国科学院心理健康重点实验室
Corresponding AuthorGarcia, R (reprint author), Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Aix Marseille Univ, Inst Neurosci Timone, UMR7289, F-13385 Marseille, France
3.CNRS, F-13385 Marseille, France
4.Univ Nice Sophia Antipolis, Dept Sci Vie, F-06108 Nice, France
5.Univ Rouen, Lab Neovasc, ERI 28, F-76183 Rouen, France
6.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zheng, Xigeng,Deschaux, Olivier,Lavigne, Jennifer,et al. Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2013,101:33-38.
APA Zheng, Xigeng.,Deschaux, Olivier.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Garcia, R .(2013).Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear.NEUROBIOLOGY OF LEARNING AND MEMORY,101,33-38.
MLA Zheng, Xigeng,et al."Prefrontal high-frequency stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear".NEUROBIOLOGY OF LEARNING AND MEMORY 101(2013):33-38.
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