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An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
Li, Lihua1; Wang, Yan2; Chen, Jun3,4; Cheng, Bi2; Hu, Jiehua5; Zhou, Yuehua6; Gao, Xin3; Gao, Liucun3; Mei, Xifan1; Sun, Meiyan7; Zhang, Zhuomei8; Song, Haifeng3; Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China.
2013
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
文章类型期刊论文
产权排序2
摘要Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
学科领域Physiological Psychology/biological Psychology,medical Psychology
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [81200262] ; Doctoral Foundation of Liaoning Province [20121092]
项目简介This study was supported by the National Natural Science Foundation of China (no. 81200262) and the Doctoral Foundation of Liaoning Province (no. 20121092).
WOS记录号WOS:000319157800001
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10640
专题健康与遗传心理学研究室
通讯作者Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China.
作者单位1.Liaoning Med Univ, Dept Biol, Jinzhou 121001, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China
4.Fourth Mil Med Univ, Tangdu Hosp, Inst Osteosarcoma, Xian 710038, Peoples R China
5.Naval Univ Engn, Educ Technol & Simulat Training Ctr, Tianjin 300450, Peoples R China
6.Shanghai Junshi Biosci Inc, Shanghai 201203, Peoples R China
7.Jilin Univ, Bethune Hosp 2, Cent Res Lab, Changchun 130041, Peoples R China
8.Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China
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GB/T 7714
Li, Lihua,Wang, Yan,Chen, Jun,et al. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Li, Lihua.,Wang, Yan.,Chen, Jun.,Cheng, Bi.,Hu, Jiehua.,...&Zhang, ZM .(2013).An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Li, Lihua,et al."An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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