PSYCH OpenIR  > 健康与遗传心理学研究室
An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
Li, Lihua1; Wang, Yan2; Chen, Jun3,4; Cheng, Bi2; Hu, Jiehua5; Zhou, Yuehua6; Gao, Xin3; Gao, Liucun3; Mei, Xifan1; Sun, Meiyan7; Zhang, Zhuomei8; Song, Haifeng3; Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China.
2013
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Subtype期刊论文
Contribution Rank2
AbstractArginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
Subject AreaPhysiological Psychology/biological Psychology,medical Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [81200262] ; Doctoral Foundation of Liaoning Province [20121092]
Project Intro.This study was supported by the National Natural Science Foundation of China (no. 81200262) and the Doctoral Foundation of Liaoning Province (no. 20121092).
WOS IDWOS:000319157800001
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10640
Collection健康与遗传心理学研究室
Corresponding AuthorZhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China.
Affiliation1.Liaoning Med Univ, Dept Biol, Jinzhou 121001, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China
4.Fourth Mil Med Univ, Tangdu Hosp, Inst Osteosarcoma, Xian 710038, Peoples R China
5.Naval Univ Engn, Educ Technol & Simulat Training Ctr, Tianjin 300450, Peoples R China
6.Shanghai Junshi Biosci Inc, Shanghai 201203, Peoples R China
7.Jilin Univ, Bethune Hosp 2, Cent Res Lab, Changchun 130041, Peoples R China
8.Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Li, Lihua,Wang, Yan,Chen, Jun,et al. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Li, Lihua.,Wang, Yan.,Chen, Jun.,Cheng, Bi.,Hu, Jiehua.,...&Zhang, ZM .(2013).An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Li, Lihua,et al."An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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