| An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo | |
| Li, Lihua1; Wang, Yan2; Chen, Jun3,4; Cheng, Bi2; Hu, Jiehua5; Zhou, Yuehua6; Gao, Xin3; Gao, Liucun3; Mei, Xifan1; Sun, Meiyan7; Zhang, Zhuomei8; Song, Haifeng3; Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China. | |
| 心理所单位排序 | 2 |
| 摘要 | Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment. |
| 学科领域 | Physiological Psychology/biological Psychology，medical Psychology |
| 2013 | |
| 语种 | 英语 |
| 发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| ISSN | 1741-427X |
| 期刊论文类型 | 期刊论文 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This study was supported by the National Natural Science Foundation of China (no. 81200262) and the Doctoral Foundation of Liaoning Province (no. 20121092). |
| WOS记录号 | WOS:000319157800001 |
| 资助机构 | National Natural Science Foundation of China [81200262] ; Doctoral Foundation of Liaoning Province [20121092] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/10640 |
| 专题 | 健康与遗传心理学研究室 |
| 通讯作者 | Zhang, ZM (reprint author), Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China. |
| 作者单位 | 1.Liaoning Med Univ, Dept Biol, Jinzhou 121001, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China 4.Fourth Mil Med Univ, Tangdu Hosp, Inst Osteosarcoma, Xian 710038, Peoples R China 5.Naval Univ Engn, Educ Technol & Simulat Training Ctr, Tianjin 300450, Peoples R China 6.Shanghai Junshi Biosci Inc, Shanghai 201203, Peoples R China 7.Jilin Univ, Bethune Hosp 2, Cent Res Lab, Changchun 130041, Peoples R China 8.Gen Hosp Chinese Armed Police, Dept Gynecol & Obstet, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lihua,Wang, Yan,Chen, Jun,et al. An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
| APA | Li, Lihua.,Wang, Yan.,Chen, Jun.,Cheng, Bi.,Hu, Jiehua.,...&Zhang, ZM .(2013).An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Li, Lihua,et al."An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000319157800001.p（2245KB） | 限制开放 | Apache License | 请求全文 | |||
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