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Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network
Wen, Xuyun1; Wu, Xia1,2; Li, Rui3; Fleisher, Adam S.4,5; Reiman, Eric M.4,6,7; Wen, Xiaotong8; Chen, Kewei4; Yao, Li1,2; Wu, X (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Wai St 19, Beijing 100875, Peoples R China.
2013
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型期刊论文
卷号1509页码:58-65
产权排序3
摘要The degree of Granger causal modeling estimated influence for a brain region was reported to predict its blood oxygenation level-dependent (BOLD) activity level in the resting-state default mode network (DMN). Many brain disorders, such as Alzheimer's disease (AD), may alter the influence strength, activity levels, or both. Whether the relationship or prediction between these two will be affected under disease condition is unknown. In this study, the spontaneous brain activity, and inter-regional Granger causality connection were investigated over eight core DMN regions in AD patients in contrast to that in normal controls. Compared to normal control (NC), AD patients had both decreased BOLD activity level and Granger causal influence in medial prefrontal cortex and decreased activity level in inferior parietal cortex showed. However, the positive correlation between the BOLD activity level and the degree of the Granger causal modeling defined influence was found not altered by AD. (C) 2013 Elsevier B.V. All rights reserved.
关键词Alzheimer's disease (AD) Default mode network (DMN) Granger causality Power Medial prefrontal cortex
学科领域Physiological Psychology/biological Psychology,psychology Of Old Age
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收录类别SCI
语种英语
项目简介This work was supported by the Fundamental Research Funds for the Central Universities National Key Basic Research Program of China (973 Program) (2012CB720704), the Key Program of National Natural Science Foundation of China (6121001), General Program of National Natural Science Foundation of China (61222113) and Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (grant Y1CX251005) and the program of State Key Laboratory of Cognitive Neuroscience and Learning (CNLYB1216).
WOS记录号WOS:000319093400006
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10641
专题中国科学院心理健康重点实验室
通讯作者Wu, X (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Wai St 19, Beijing 100875, Peoples R China.
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Banner Alzheimers Inst, Arizona Alzheimers Consortium, Phoenix, AZ USA
5.Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA
6.Univ Arizona, Coll Med, Dept Psychiat, Phoenix, AZ USA
7.Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ USA
8.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA
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Wen, Xuyun,Wu, Xia,Li, Rui,et al. Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network[J]. BRAIN RESEARCH,2013,1509:58-65.
APA Wen, Xuyun.,Wu, Xia.,Li, Rui.,Fleisher, Adam S..,Reiman, Eric M..,...&Wu, X .(2013).Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network.BRAIN RESEARCH,1509,58-65.
MLA Wen, Xuyun,et al."Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network".BRAIN RESEARCH 1509(2013):58-65.
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