PSYCH OpenIR  > 中国科学院心理健康重点实验室
Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
Li, Man1; Xue, Xiaofang1; Shao, Shuang1; Shao, Feng1; Wang, Weiwen2; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2013
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型期刊论文
卷号1518页码:82-90
产权排序1
摘要As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved.
关键词Maternal separation Prepulse inhibition Anxiety Dopamine D2 receptor 5-HT1A receptor Prefrontal cortex Nucleus accumbens Hippocampus
学科领域Cognitive Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This work was supported by the National Natural Science Foundation of China (Grant no. 31070910), the National Natural Science Foundation of China (Grant no. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000321082900008
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10642
专题中国科学院心理健康重点实验室
通讯作者Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Li, Man,Xue, Xiaofang,Shao, Shuang,et al. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats[J]. BRAIN RESEARCH,2013,1518:82-90.
APA Li, Man,Xue, Xiaofang,Shao, Shuang,Shao, Feng,Wang, Weiwen,&Shao, F .(2013).Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats.BRAIN RESEARCH,1518,82-90.
MLA Li, Man,et al."Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats".BRAIN RESEARCH 1518(2013):82-90.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000321082900008.p(5065KB) 限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Man]的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
百度学术
百度学术中相似的文章
[Li, Man]的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
必应学术
必应学术中相似的文章
[Li, Man]的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000321082900008.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。