PSYCH OpenIR  > 中国科学院心理健康重点实验室
Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
Li, Man1; Xue, Xiaofang1; Shao, Shuang1; Shao, Feng1; Wang, Weiwen2; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2013
Source PublicationBRAIN RESEARCH
ISSN0006-8993
Subtype期刊论文
Volume1518Pages:82-90
Contribution Rank1
AbstractAs an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved.
KeywordMaternal separation Prepulse inhibition Anxiety Dopamine D2 receptor 5-HT1A receptor Prefrontal cortex Nucleus accumbens Hippocampus
Subject AreaCognitive Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.This work was supported by the National Natural Science Foundation of China (Grant no. 31070910), the National Natural Science Foundation of China (Grant no. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS IDWOS:000321082900008
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Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10642
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Man,Xue, Xiaofang,Shao, Shuang,et al. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats[J]. BRAIN RESEARCH,2013,1518:82-90.
APA Li, Man,Xue, Xiaofang,Shao, Shuang,Shao, Feng,Wang, Weiwen,&Shao, F .(2013).Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats.BRAIN RESEARCH,1518,82-90.
MLA Li, Man,et al."Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats".BRAIN RESEARCH 1518(2013):82-90.
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