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| Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats | |
Li, Man1; Xue, Xiaofang1; Shao, Shuang1; Shao, Feng1; Wang, Weiwen2 ; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
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| 心理所单位排序 | 1 |
| 摘要 | As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on PPI and anxiety-related behaviors in an elevated plus maze, as well as dopamine D2 receptor (DRD2) and 5-HT1A receptor expression in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus in adolescent rats. Our findings show that repeated MS results in reduced PPI, increased anxiety-related behaviors, decreased DRD2 protein expression in the NAc and hippocampus, and decreased 5-HT1A protein expression in the mPFC and hippocampus in adolescent rats. These data further demonstrate that MS can be used as an animal model of neuropsychiatric disease. (c) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Maternal separation Prepulse inhibition Anxiety Dopamine D2 receptor 5-HT1A receptor Prefrontal cortex Nucleus accumbens Hippocampus |
| 学科领域 | Cognitive Psychology |
| 2013 | |
| 语种 | 英语 |
| 发表期刊 | BRAIN RESEARCH
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| ISSN | 0006-8993 |
| 卷号 | 1518页码:82-90 |
| 期刊论文类型 | 期刊论文 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural Science Foundation of China (Grant no. 31070910), the National Natural Science Foundation of China (Grant no. 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| WOS记录号 | WOS:000321082900008 |
| 资助机构 | National Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/10642 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Man,Xue, Xiaofang,Shao, Shuang,et al. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats[J]. BRAIN RESEARCH,2013,1518:82-90. |
| APA | Li, Man,Xue, Xiaofang,Shao, Shuang,Shao, Feng,Wang, Weiwen,&Shao, F .(2013).Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats.BRAIN RESEARCH,1518,82-90. |
| MLA | Li, Man,et al."Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats".BRAIN RESEARCH 1518(2013):82-90. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000321082900008.p（5065KB） | 限制开放 | Apache License | 请求全文 | |||
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