Brain structural plasticity in survivors of a major earthquake

	Brain structural plasticity in survivors of a major earthquake
	Lui, Su 1; Chen, Long 1; Yao, Li 1; Xiao, Yuan 1; Wu, Qi-Zhu 1; Zhang, Jun-Ran 1; Huang, Xiao-Qi 1; Zhang, Wei 2; Wang, Yu-Qin ; Chen, Hua-Fu 3; Chan, Raymond C. K.4; Sweeney, John A.5; Gong, Qi-Yong 1; Gong, QY (reprint author), West China Hosp Sichuan Univ, Ctr Med Imaging, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
心理所单位排序	4
摘要	Background: Stress responses have been studied extensively in animal models, but effects of major life stress on the human brain remain poorly understood. The aim of this study was to determine whether survivors of a major earthquake, who were presumed to have experienced extreme emotional stress during the disaster, demonstrate differences in brain anatomy relative to individuals who have not experienced such stressors. Methods: Healthy survivors living in an area devastated by a major earthquake and matched healthy controls underwent 3-dimentional high-resolution magnetic resonance imaging (MRI). Survivors were scanned 13-25 days after the earthquake; controls had undergone MRI for other studies not long before the earthquake. We used optimized voxel-based morphometry analysis to identify regional differences of grey matter volume between the survivors and controls. Results: We included 44 survivors (17 female, mean age 37 [standard deviation (SD) 10.6] yr) and 38 controls (14 female, mean age 35.3 [SD 11.2] yr) in our analysis. Compared with controls, the survivors showed significantly lower grey matter volume in the bilateral insula, hippocampus, left caudate and putamen, and greater grey matter volume in the bilateral orbitofrontal cortex and the parietal lobe (all p < 0.05, corrected for multiple comparison). Limitations: Differences in the variance of survivor and control data could impact study findings. Conclusion: Acute anatomic alterations could be observed in earthquake survivors in brain regions where functional alterations after stress have been described. Anatomic changes in the present study were observed earlier than previously reported and were seen in prefrontal-limbic, parietal and striatal brain systems. Together with the results of previous functional imaging studies, our observations suggest a complex pattern of human brain response to major life stress affecting brain systems that modulate and respond to heightened affective arousal.
学科领域	Trauma Psychology
	2013
语种	英语
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN	1180-4882
卷号	38 期号:6 页码:381-387
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was supported by National Natural Science Foundation (Grant Nos. 81222018,81030027, 81227002 and 81220108013), the Programs for New Century Excellent Talents in University (Grant No. NCET-10-0596) and National Key Technologies R&D Program of China (Program No: 2012BAI01B03) and the von Humboldt Foundation. Q.-Y. Gong acknowledges support from his American CMB Distinguished Professorship Award (Award No. F510000/G16916411), administered by the Institute of International Education. S. Lui is supported by the Distinguished Young Scholars of Sichuan (Award No. 2011JQ0005).
WOS记录号	WOS:000330526000004
资助机构	National Natural Science Foundation [81222018, 81030027, 81227002, 81220108013] ; Programs for New Century Excellent Talents in University [NCET-10-0596] ; National Key Technologies R&D Program of China [2012BAI01B03] ; von Humboldt Foundation ; American CMB Distinguished Professorship Award [F510000/G16916411] ; Distinguished Young Scholars of Sichuan [2011JQ0005]
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10646
专题	脑与认知科学国家重点实验室
通讯作者	Gong, QY (reprint author), West China Hosp Sichuan Univ, Ctr Med Imaging, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
作者单位	1.West China Hosp Sichuan Univ, HMRRC, Dept Radiol, Chengdu 610041, Peoples R China 2.West China Hosp Sichuan Univ, State Key Lab Biotherapy, Dept Psychiat, Chengdu 610041, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100864, Peoples R China 5.Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
推荐引用方式 GB/T 7714	Lui, Su,Chen, Long,Yao, Li,et al. Brain structural plasticity in survivors of a major earthquake[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2013,38(6):381-387.
APA	Lui, Su.,Chen, Long.,Yao, Li.,Xiao, Yuan.,Wu, Qi-Zhu.,...&Gong, QY .(2013).Brain structural plasticity in survivors of a major earthquake.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,38(6),381-387.
MLA	Lui, Su,et al."Brain structural plasticity in survivors of a major earthquake".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 38.6(2013):381-387.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS000330526000004.p（1268KB）			限制开放	Apache License	请求全文