PSYCH OpenIR  > 脑与认知科学国家重点实验室
Brain structural plasticity in survivors of a major earthquake
Lui, Su1; Chen, Long1; Yao, Li1; Xiao, Yuan1; Wu, Qi-Zhu1; Zhang, Jun-Ran1; Huang, Xiao-Qi1; Zhang, Wei2; Wang, Yu-Qin; Chen, Hua-Fu3; Chan, Raymond C. K.4; Sweeney, John A.5; Gong, Qi-Yong1; Gong, QY (reprint author), West China Hosp Sichuan Univ, Ctr Med Imaging, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
2013
发表期刊JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN1180-4882
文章类型期刊论文
卷号38期号:6页码:381-387
产权排序4
摘要Background: Stress responses have been studied extensively in animal models, but effects of major life stress on the human brain remain poorly understood. The aim of this study was to determine whether survivors of a major earthquake, who were presumed to have experienced extreme emotional stress during the disaster, demonstrate differences in brain anatomy relative to individuals who have not experienced such stressors. Methods: Healthy survivors living in an area devastated by a major earthquake and matched healthy controls underwent 3-dimentional high-resolution magnetic resonance imaging (MRI). Survivors were scanned 13-25 days after the earthquake; controls had undergone MRI for other studies not long before the earthquake. We used optimized voxel-based morphometry analysis to identify regional differences of grey matter volume between the survivors and controls. Results: We included 44 survivors (17 female, mean age 37 [standard deviation (SD) 10.6] yr) and 38 controls (14 female, mean age 35.3 [SD 11.2] yr) in our analysis. Compared with controls, the survivors showed significantly lower grey matter volume in the bilateral insula, hippocampus, left caudate and putamen, and greater grey matter volume in the bilateral orbitofrontal cortex and the parietal lobe (all p < 0.05, corrected for multiple comparison). Limitations: Differences in the variance of survivor and control data could impact study findings. Conclusion: Acute anatomic alterations could be observed in earthquake survivors in brain regions where functional alterations after stress have been described. Anatomic changes in the present study were observed earlier than previously reported and were seen in prefrontal-limbic, parietal and striatal brain systems. Together with the results of previous functional imaging studies, our observations suggest a complex pattern of human brain response to major life stress affecting brain systems that modulate and respond to heightened affective arousal.
学科领域Trauma Psychology
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation [81222018, 81030027, 81227002, 81220108013] ; Programs for New Century Excellent Talents in University [NCET-10-0596] ; National Key Technologies R&D Program of China [2012BAI01B03] ; von Humboldt Foundation ; American CMB Distinguished Professorship Award [F510000/G16916411] ; Distinguished Young Scholars of Sichuan [2011JQ0005]
项目简介This study was supported by National Natural Science Foundation (Grant Nos. 81222018,81030027, 81227002 and 81220108013), the Programs for New Century Excellent Talents in University (Grant No. NCET-10-0596) and National Key Technologies R&D Program of China (Program No: 2012BAI01B03) and the von Humboldt Foundation. Q.-Y. Gong acknowledges support from his American CMB Distinguished Professorship Award (Award No. F510000/G16916411), administered by the Institute of International Education. S. Lui is supported by the Distinguished Young Scholars of Sichuan (Award No. 2011JQ0005).
WOS记录号WOS:000330526000004
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10646
专题脑与认知科学国家重点实验室
通讯作者Gong, QY (reprint author), West China Hosp Sichuan Univ, Ctr Med Imaging, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
作者单位1.West China Hosp Sichuan Univ, HMRRC, Dept Radiol, Chengdu 610041, Peoples R China
2.West China Hosp Sichuan Univ, State Key Lab Biotherapy, Dept Psychiat, Chengdu 610041, Peoples R China
3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100864, Peoples R China
5.Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
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Lui, Su,Chen, Long,Yao, Li,et al. Brain structural plasticity in survivors of a major earthquake[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2013,38(6):381-387.
APA Lui, Su.,Chen, Long.,Yao, Li.,Xiao, Yuan.,Wu, Qi-Zhu.,...&Gong, QY .(2013).Brain structural plasticity in survivors of a major earthquake.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,38(6),381-387.
MLA Lui, Su,et al."Brain structural plasticity in survivors of a major earthquake".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 38.6(2013):381-387.
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