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BDNF and TNF-alpha polymorphisms in memory
Yogeetha, B. S.1,2; Haupt, L. M.1,2; McKenzie, K.1,2; Sutherland, H. G.1,2; Okolicsyani, R. K.1,2; Lea, R. A.1,2; Maher, B. H.1,2; Chan, R. C. K.3; Shum, D. H. K.2,4; Griffiths, L. R.1,2; Griffiths, LR (reprint author), Griffith Univ, Genom Res Ctr, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia.
2013
Source PublicationMOLECULAR BIOLOGY REPORTS
ISSN0301-4851
Subtype期刊论文
Volume40Issue:9Pages:5483-5490
Contribution Rank2
AbstractHere, we investigate the genetic basis of human memory in healthy individuals and the potential role of two polymorphisms, previously implicated in memory function. We have explored aspects of retrospective and prospective memory including semantic, short term, working and long-term memory in conjunction with brain derived neurotrophic factor (BDNF) and tumor necrosis factor-alpha (TNF-alpha). The memory scores for healthy individuals in the population were obtained for each memory type and the population was genotyped via restriction fragment length polymorphism for the BDNF rs6265 (Val66Met) SNP and via pyrosequencing for the TNF-alpha rs113325588 SNP. Using univariate ANOVA, a significant association of the BDNF polymorphism with visual and spatial memory retention and a significant association of the TNF-alpha polymorphism was observed with spatial memory retention. In addition, a significant interactive effect between BDNF and TNF-alpha polymorphisms was observed in spatial memory retention. In practice visual memory involves spatial information and the two memory systems work together, however our data demonstrate that individuals with the Val/Val BDNF genotype have poorer visual memory but higher spatial memory retention, indicating a level of interaction between TNF-alpha and BDNF in spatial memory retention. This is the first study to use genetic analysis to determine the interaction between BDNF and TNF-alpha in relation to memory in normal adults and provides important information regarding the effect of genetic determinants and gene interactions on human memory.
KeywordBrain-derived neurotropic factor (BDNF) Memory Genotype Retrospective memory Prospective memory Gene interactions
Subject AreaCognitive Psychology
Indexed BySCI
Language英语
Funding OrganizationGenomics Research Centre (GRC), Griffith Health Institute (GHI) ; School of Medical Science at Griffith University Gold Coast campus
Project Intro.This research was supported by the Genomics Research Centre (GRC), Griffith Health Institute (GHI) and the School of Medical Science at Griffith University Gold Coast campus.
WOS IDWOS:000323504000027
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10654
Collection脑与认知科学国家重点实验室
Corresponding AuthorGriffiths, LR (reprint author), Griffith Univ, Genom Res Ctr, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia.
Affiliation1.Griffith Univ, Genom Res Ctr, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia
2.Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
4.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia
Recommended Citation
GB/T 7714
Yogeetha, B. S.,Haupt, L. M.,McKenzie, K.,et al. BDNF and TNF-alpha polymorphisms in memory[J]. MOLECULAR BIOLOGY REPORTS,2013,40(9):5483-5490.
APA Yogeetha, B. S..,Haupt, L. M..,McKenzie, K..,Sutherland, H. G..,Okolicsyani, R. K..,...&Griffiths, LR .(2013).BDNF and TNF-alpha polymorphisms in memory.MOLECULAR BIOLOGY REPORTS,40(9),5483-5490.
MLA Yogeetha, B. S.,et al."BDNF and TNF-alpha polymorphisms in memory".MOLECULAR BIOLOGY REPORTS 40.9(2013):5483-5490.
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