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Brain-network mechanisms underlying the divergent effects of depression on spontaneous versus evoked pain in rats: A multiple single-unit study
Wang, Ning; Shi, Miao; Wang, Jin-Yan; Luo, Fei; Wang, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
2013
Source PublicationEXPERIMENTAL NEUROLOGY
ISSN0014-4886
Subtype期刊论文
Volume250Pages:165-175
Contribution Rank1
AbstractStudies have reported divergent behavioral effects of depression on spontaneous vs. stimulus-evoked pain. However, the underlying neurobiological mechanisms are still unclear. The present study used a depression model of unpredictable chronic mild stress (UCMS) and pain models for spontaneous pain (i.e., the formalin test) and acute evoked pain (i.e., noxious thermal stimulation) in rats. The activity of neurons within thalamo-cortical circuits in the lateral and medial pain pathways was recorded by a multiple-channel recording technique, and behaviors were observed simultaneously. The results confirmed our previous findings that rats exposed to UCMS tended to exhibit decreased pain sensitivity to experimental stimuli but increased behavioral responses to ongoing pain. Based on the analysis of single-unit responses, the results demonstrated that the processing of spontaneous vs. evoked pain in a depressive-like state was altered in the opposite direction (activation vs. inhibition). The ensemble encoding analysis revealed that exposure to UCMS gave rise to enhanced inter-regional functional connectivity in spontaneous pain processing, but did not influence that of evoked pain. In addition, different brain activation patterns underlying the processing of spontaneous vs. evoked pain were observed. These findings revealed that the distinct response patterns of neurons within the pain-related brain circuits, especially in the affective pain pathway, mediate the divergent effects of depression on spontaneous vs. evoked pain. This is also the first report on the electrophysiology of depression models that provides direct evidence that the effect of depression on spontaneous and evoked pain may involve different brain mechanisms. (C) 2013 Elsevier Inc. All rights reserved.
KeywordCortex Depression Pain pathway Rat Single unit Thalamus
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNNSF [81100828, 31271092, 30970959, 61033011, 31171067] ; Chinese Academy of Sciences Knowledge Innovation Project [KSCX2-EW-Q-18, YZ200944, KSCX2-YW-R-254, KSCX2-EW-J-8] ; NIH Fogarty International Center [R03 TW008038] ; Key Laboratory of Mental Health at the Institute of Psychology, Chinese Academy of Sciences, China
Project Intro.This work was funded by an NNSF grant (81100828) to N.W., an NNSF grant (31271092) and a Chinese Academy of Sciences Knowledge Innovation Project grant (KSCX2-EW-Q-18) awarded to J.Y.W., as well as NNSF grants (30970959, 61033011, and 31171067), Chinese Academy of Sciences Knowledge Innovation Project grants (YZ200944, KSCX2-YW-R-254, and KSCX2-EW-J-8), and a grant from the NIH Fogarty International Center (R03 TW008038) awarded to F.L. This research was also supported by the Key Laboratory of Mental Health at the Institute of Psychology, Chinese Academy of Sciences, China.
WOS IDWOS:000328305600018
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10660
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
AffiliationChinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Ning,Shi, Miao,Wang, Jin-Yan,et al. Brain-network mechanisms underlying the divergent effects of depression on spontaneous versus evoked pain in rats: A multiple single-unit study[J]. EXPERIMENTAL NEUROLOGY,2013,250:165-175.
APA Wang, Ning,Shi, Miao,Wang, Jin-Yan,Luo, Fei,&Wang, JY .(2013).Brain-network mechanisms underlying the divergent effects of depression on spontaneous versus evoked pain in rats: A multiple single-unit study.EXPERIMENTAL NEUROLOGY,250,165-175.
MLA Wang, Ning,et al."Brain-network mechanisms underlying the divergent effects of depression on spontaneous versus evoked pain in rats: A multiple single-unit study".EXPERIMENTAL NEUROLOGY 250(2013):165-175.
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