Institutional Repository of Key Laboratory of Mental Health, CAS
Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease | |
Li, R.1; Wu, X.2,3; Chen, K.4,5; Fleisher, A. S.4,5,6; Reiman, E. M.4,5; Yao, L.2,3; Wu, X (reprint author), Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China. | |
心理所单位排序 | 1 |
摘要 | BACKGROUND AND PURPOSE: AD has been documented as a kind of disconnection syndrome by functional neuroimaging studies. The primary focus of this study was to examine, with the use of resting-state fMRI, whether AD would impact connectivity among RSNs. MATERIALS AND METHODS: Fourteen patients with AD and 16 NC were recruited and scanned by using resting-state fMRI. Group independent-component analysis and the BN learning approach were used, respectively, to separate the RSNs and construct the network-to-network connectivity patterns for each group. The convergence index for the special network DMN was measured. RESULTS: Three of the 4 connections were significantly lower in AD compared with NC. Although numerically the AD group had more connections, none was statistically different from that in the NC group except for 1 increased connection from the DMN to the DAN. The convergence index for the DMN node was lower in AD than in NC. CONCLUSIONS: Connections among cognitive networks in AD were more vulnerable to impairment than sensory networks. The DMN decreased its integration function for other RSNs but may also play a role in compensating for the disrupted connections in AD. |
学科领域 | Medical Psychology |
2013 | |
语种 | 英语 |
发表期刊 | AMERICAN JOURNAL OF NEURORADIOLOGY |
ISSN | 0195-6108 |
卷号 | 34期号:2页码:340-345 |
期刊论文类型 | 期刊论文 |
URL | 查看原文 |
收录类别 | SCI |
项目简介 | This work was supported by the Key Program of National Natural Science Foundation of China (grant 60931003), General Program of National Natural Science Foundation of China (grant 60905063), and Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (grant Y1CX251005). It was also supported by the National Institute of Mental Health (RO1 MH57899), the National Institute on Aging (R01 AG031581-10 and P30 AG19610, k23 AG24062), and the state of Arizona. |
WOS记录号 | WOS:000329210300019 |
资助机构 | National Natural Science Foundation of China [30625024, 81030027, 81030028, 30870667, 30728017, 30960099] ; National Basic Research Program (973 Program) [2007CB512305/2] ; National High Technology Program of China (863 Program) [2008AA02Z408] |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/10661 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wu, X (reprint author), Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China. |
作者单位 | 1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 3.Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China 4.Banner Alzheimers Inst, Phoenix, AZ USA 5.Banner Good Samaritan PET Ctr, Phoenix, AZ USA 6.Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA |
推荐引用方式 GB/T 7714 | Li, R.,Wu, X.,Chen, K.,et al. Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2013,34(2):340-345. |
APA | Li, R..,Wu, X..,Chen, K..,Fleisher, A. S..,Reiman, E. M..,...&Wu, X .(2013).Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease.AMERICAN JOURNAL OF NEURORADIOLOGY,34(2),340-345. |
MLA | Li, R.,et al."Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease".AMERICAN JOURNAL OF NEURORADIOLOGY 34.2(2013):340-345. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS000329210300019.p(1197KB) | 限制开放 | CC BY-NC-ND | 请求全文 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Li, R.]的文章 |
[Wu, X.]的文章 |
[Chen, K.]的文章 |
百度学术 |
百度学术中相似的文章 |
[Li, R.]的文章 |
[Wu, X.]的文章 |
[Chen, K.]的文章 |
必应学术 |
必应学术中相似的文章 |
[Li, R.]的文章 |
[Wu, X.]的文章 |
[Chen, K.]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论