PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease
Li, R.1; Wu, X.2,3; Chen, K.4,5; Fleisher, A. S.4,5,6; Reiman, E. M.4,5; Yao, L.2,3; Wu, X (reprint author), Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China.
2013
Source PublicationAMERICAN JOURNAL OF NEURORADIOLOGY
ISSN0195-6108
Subtype期刊论文
Volume34Issue:2Pages:340-345
Contribution Rank1
AbstractBACKGROUND AND PURPOSE: AD has been documented as a kind of disconnection syndrome by functional neuroimaging studies. The primary focus of this study was to examine, with the use of resting-state fMRI, whether AD would impact connectivity among RSNs. MATERIALS AND METHODS: Fourteen patients with AD and 16 NC were recruited and scanned by using resting-state fMRI. Group independent-component analysis and the BN learning approach were used, respectively, to separate the RSNs and construct the network-to-network connectivity patterns for each group. The convergence index for the special network DMN was measured. RESULTS: Three of the 4 connections were significantly lower in AD compared with NC. Although numerically the AD group had more connections, none was statistically different from that in the NC group except for 1 increased connection from the DMN to the DAN. The convergence index for the DMN node was lower in AD than in NC. CONCLUSIONS: Connections among cognitive networks in AD were more vulnerable to impairment than sensory networks. The DMN decreased its integration function for other RSNs but may also play a role in compensating for the disrupted connections in AD.
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [30625024, 81030027, 81030028, 30870667, 30728017, 30960099] ; National Basic Research Program (973 Program) [2007CB512305/2] ; National High Technology Program of China (863 Program) [2008AA02Z408]
Project Intro.This work was supported by the Key Program of National Natural Science Foundation of China (grant 60931003), General Program of National Natural Science Foundation of China (grant 60905063), and Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (grant Y1CX251005). It was also supported by the National Institute of Mental Health (RO1 MH57899), the National Institute on Aging (R01 AG031581-10 and P30 AG19610, k23 AG24062), and the state of Arizona.
WOS IDWOS:000329210300019
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10661
Collection中国科学院心理健康重点实验室
Corresponding AuthorWu, X (reprint author), Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China.
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China
4.Banner Alzheimers Inst, Phoenix, AZ USA
5.Banner Good Samaritan PET Ctr, Phoenix, AZ USA
6.Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA
Recommended Citation
GB/T 7714
Li, R.,Wu, X.,Chen, K.,et al. Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2013,34(2):340-345.
APA Li, R..,Wu, X..,Chen, K..,Fleisher, A. S..,Reiman, E. M..,...&Wu, X .(2013).Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease.AMERICAN JOURNAL OF NEURORADIOLOGY,34(2),340-345.
MLA Li, R.,et al."Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease".AMERICAN JOURNAL OF NEURORADIOLOGY 34.2(2013):340-345.
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