PSYCH OpenIR  > 中国科学院心理健康重点实验室
Maternal separation induces alterations of serotonergic system in different aged rats
Xue, Xiaofang1; Shao, Shuang1; Li, Man1; Shao, Feng1; Wang, Weiwen2
2013-06-01
发表期刊BRAIN RESEARCH BULLETIN
卷号95期号:0页码:15-20
摘要Maternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus of juvenile (post-natal day 21, PND 21), adolescent (PND 35) and early adult (PND 56) male Wistar rats. We found that MS increased 5-HT levels in the PFC of juvenile rats, and although MS increased 5-HT and 5-HIAA levels in the NAc of adolescent rats, the ratio between 5-HIAA and 5-HT decreased in the PFC. In addition, MS-treated adult rats showed increased levels of 5-HT in the PFC as well as 5-HT and 5-HIAA in the NAc. These data provided evidence that MS leads to profound and age-specific changes in serotonergic synthesis and activity in rodents. Our study also found that there are U-shaped and inverted U-shaped patterns for serotonergic synthesis and serotonergic activity from younger rats to adults, respectively. Together, our findings support the use of maternal separation as an animal model for studying the neurobiological pathogenesis of neurodevelopmental diseases. (C) 2013 Elsevier Inc. All rights reserved.
关键词Maternal separation 5-HT Prefrontal cortex Nucleus accumbens Hippocampus
收录类别SCI
语种英语
WOS记录号WOS:000325741300003
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10662
专题中国科学院心理健康重点实验室
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Xue, Xiaofang,Shao, Shuang,Li, Man,et al. Maternal separation induces alterations of serotonergic system in different aged rats[J]. BRAIN RESEARCH BULLETIN,2013,95(0):15-20.
APA Xue, Xiaofang,Shao, Shuang,Li, Man,Shao, Feng,&Wang, Weiwen.(2013).Maternal separation induces alterations of serotonergic system in different aged rats.BRAIN RESEARCH BULLETIN,95(0),15-20.
MLA Xue, Xiaofang,et al."Maternal separation induces alterations of serotonergic system in different aged rats".BRAIN RESEARCH BULLETIN 95.0(2013):15-20.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000325741300003.(948KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
[Li, Man]的文章
百度学术
百度学术中相似的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
[Li, Man]的文章
必应学术
必应学术中相似的文章
[Xue, Xiaofang]的文章
[Shao, Shuang]的文章
[Li, Man]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS_000325741300003.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。