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Maternal separation induces alterations of serotonergic system in different aged rats
Xue, Xiaofang1; Shao, Shuang1; Li, Man1; Shao, Feng1; Wang, Weiwen2
2013-06-01
Source PublicationBRAIN RESEARCH BULLETIN
Volume95Issue:0Pages:15-20
AbstractMaternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus of juvenile (post-natal day 21, PND 21), adolescent (PND 35) and early adult (PND 56) male Wistar rats. We found that MS increased 5-HT levels in the PFC of juvenile rats, and although MS increased 5-HT and 5-HIAA levels in the NAc of adolescent rats, the ratio between 5-HIAA and 5-HT decreased in the PFC. In addition, MS-treated adult rats showed increased levels of 5-HT in the PFC as well as 5-HT and 5-HIAA in the NAc. These data provided evidence that MS leads to profound and age-specific changes in serotonergic synthesis and activity in rodents. Our study also found that there are U-shaped and inverted U-shaped patterns for serotonergic synthesis and serotonergic activity from younger rats to adults, respectively. Together, our findings support the use of maternal separation as an animal model for studying the neurobiological pathogenesis of neurodevelopmental diseases. (C) 2013 Elsevier Inc. All rights reserved.
KeywordMaternal separation 5-HT Prefrontal cortex Nucleus accumbens Hippocampus
Indexed BySCI
Language英语
WOS IDWOS:000325741300003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10662
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Xue, Xiaofang,Shao, Shuang,Li, Man,et al. Maternal separation induces alterations of serotonergic system in different aged rats[J]. BRAIN RESEARCH BULLETIN,2013,95(0):15-20.
APA Xue, Xiaofang,Shao, Shuang,Li, Man,Shao, Feng,&Wang, Weiwen.(2013).Maternal separation induces alterations of serotonergic system in different aged rats.BRAIN RESEARCH BULLETIN,95(0),15-20.
MLA Xue, Xiaofang,et al."Maternal separation induces alterations of serotonergic system in different aged rats".BRAIN RESEARCH BULLETIN 95.0(2013):15-20.
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