Maternal separation induces alterations of serotonergic system in different aged rats

	Maternal separation induces alterations of serotonergic system in different aged rats
	Xue, Xiaofang 1; Shao, Shuang 1; Li, Man 1; Shao, Feng 1; Wang, Weiwen2
摘要	Maternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus of juvenile (post-natal day 21, PND 21), adolescent (PND 35) and early adult (PND 56) male Wistar rats. We found that MS increased 5-HT levels in the PFC of juvenile rats, and although MS increased 5-HT and 5-HIAA levels in the NAc of adolescent rats, the ratio between 5-HIAA and 5-HT decreased in the PFC. In addition, MS-treated adult rats showed increased levels of 5-HT in the PFC as well as 5-HT and 5-HIAA in the NAc. These data provided evidence that MS leads to profound and age-specific changes in serotonergic synthesis and activity in rodents. Our study also found that there are U-shaped and inverted U-shaped patterns for serotonergic synthesis and serotonergic activity from younger rats to adults, respectively. Together, our findings support the use of maternal separation as an animal model for studying the neurobiological pathogenesis of neurodevelopmental diseases. (C) 2013 Elsevier Inc. All rights reserved.
关键词	Maternal separation 5-HT Prefrontal cortex Nucleus accumbens Hippocampus
	2013-06-01
语种	英语
发表期刊	BRAIN RESEARCH BULLETIN
卷号	95 期号:0 页码:15-20
收录类别	SCI
WOS记录号	WOS:000325741300003
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10662
专题	中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Xue, Xiaofang,Shao, Shuang,Li, Man,et al. Maternal separation induces alterations of serotonergic system in different aged rats[J]. BRAIN RESEARCH BULLETIN,2013,95(0):15-20.
APA	Xue, Xiaofang,Shao, Shuang,Li, Man,Shao, Feng,&Wang, Weiwen.(2013).Maternal separation induces alterations of serotonergic system in different aged rats.BRAIN RESEARCH BULLETIN,95(0),15-20.
MLA	Xue, Xiaofang,et al."Maternal separation induces alterations of serotonergic system in different aged rats".BRAIN RESEARCH BULLETIN 95.0(2013):15-20.

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