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Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study
Fan, Feng-Mei; Tan, Shu-Ping; Yang, Fu-De; Tan, Yun-Long; Zhao, Yan-Li; Chen, Nan; Li, Bin-Bin; Song, Chong-Sheng; Wang, Yun-Hui; Jin, Zhen; Zhou, Dong-Feng; Milham, Michael P.; Zou, Yi-Zhuang; Zuo, Xi-Nian; Zou, YZ (reprint author), Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China.
2013
Source PublicationNEUROSCIENCE BULLETIN
ISSN0304-3940
Subtype期刊论文
Volume29Issue:1Pages:59-74
Contribution Rank2
AbstractPeople with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia.
Keywordschizophrenia emotion regulation ventral medial prefrontal cortex functional connectivity resting state functional MRI
Subject AreaAbnormal Psychology,Physiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationBeijing Municipal Science & Technology Commission [D0906001040191, D101107047810005, D101100050010051] ; Beijing Natural Science Foundation [7102086] ; Fund for Capital Medical Development and Research [2007-3059] ; National Natural Science Foundation of China [81171409] ; Startup Foundation for Distinguished Research Professors of the Institute for Psychology [Y0CX492S03] ; Fund for Outstanding Talents in Beijing [2012D003034000003]
Project Intro.We are grateful to all the volunteers and patients for their participation in the study. We thank Yu-Feng Zang for assistance in providing resting-state fMRI scanning parameters, and Matthew J. Hoptman and Raymond C. K. Chan for helpful editorial advice and comments. This work was supported by grants from the Beijing Municipal Science & Technology Commission (D0906001040191, D101107047810005, D101100050010051), the Beijing Natural Science Foundation (7102086) and the Fund for Capital Medical Development and Research (2007-3059), the National Natural Science Foundation of China (81171409) and the Startup Foundation for Distinguished Research Professors of the Institute for Psychology (Y0CX492S03) and Fund for Outstanding Talents in Beijing (2012D003034000003).
WOS IDWOS:000314298300009
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10664
Collection中国科学院行为科学重点实验室
Corresponding AuthorZou, YZ (reprint author), Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China.
AffiliationZou, YZ (reprint author), Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China.
Recommended Citation
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Fan, Feng-Mei,Tan, Shu-Ping,Yang, Fu-De,et al. Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study[J]. NEUROSCIENCE BULLETIN,2013,29(1):59-74.
APA Fan, Feng-Mei.,Tan, Shu-Ping.,Yang, Fu-De.,Tan, Yun-Long.,Zhao, Yan-Li.,...&Zou, YZ .(2013).Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study.NEUROSCIENCE BULLETIN,29(1),59-74.
MLA Fan, Feng-Mei,et al."Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study".NEUROSCIENCE BULLETIN 29.1(2013):59-74.
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