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Stathmin genotype is associated with reexperiencing symptoms of posttraumatic stress disorder in Chinese earthquake survivors
Cao, Chengqi; Wang, Li; Wang, Richu; Dong, Chongya; Qing, Yulan; Zhang, Xiangyang; Zhang, Jianxin; Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
文章类型期刊论文
卷号44页码:296-300
产权排序1
摘要Stathmin (STMN1) has been demonstrated as a regulator of fear processing across species, which implicates that it may be important in the etiopathogenesis of fear-related psychiatric disorders such as posttraumatic stress disorder (PTSD). This study examined the association between STMN1 rs182455 genotype, a single nucleotide polymorphism (SNP) located within or close to the putative transcriptional control region of STMN1 gene, and PTSD symptoms. A total of 326 Chinese adults who suffered from a deadly 2008 Wenchuan earthquake and unexpectedly lost their children during the disaster participated in this study. PTSD symptoms were measured with the PTSD Checklist (PCL). The Sequenom iPlex chemistries and the MassARRAY system were used to genotype the STMN1 rs182455 SNP. Our results indicated that the STMN1rs182455 genotype was not associated with severity of total PTSD symptoms in either females or males; however, it could significantly predict severity of PTSD's reexperiencing symptoms in females. The findings provide preliminary evidence supporting the important role of STMN1 in the development of PTSD, and expand extant knowledge on the genetic underpinnings of PTSD and the sex-specific expression of PTSD's symptoms. (C) 2013 Elsevier Inc. All rights reserved.
关键词Association study PTSD Single-nucleotide polymorphism Stathmin
学科领域Trauma Psychology
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收录类别SCI
语种英语
项目资助者National Key Technology Research and Development Program of China [2013BAI08B02] ; Chinese Academy of Sciences [KSCX2-EW-Q-18] ; National Natural Science Foundation of China [30900402, 31271099] ; Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This study was supported partially by the National Key Technology Research and Development Program of China (No. 2013BAI08B02), the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KSCX2-EW-Q-18), the National Natural Science Foundation of China (No. 30900402 and No. 31271099), the Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences, and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000320297400039
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10669
专题中国科学院心理健康重点实验室
通讯作者Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
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Cao, Chengqi,Wang, Li,Wang, Richu,et al. Stathmin genotype is associated with reexperiencing symptoms of posttraumatic stress disorder in Chinese earthquake survivors[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,44:296-300.
APA Cao, Chengqi.,Wang, Li.,Wang, Richu.,Dong, Chongya.,Qing, Yulan.,...&Wang, L .(2013).Stathmin genotype is associated with reexperiencing symptoms of posttraumatic stress disorder in Chinese earthquake survivors.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,44,296-300.
MLA Cao, Chengqi,et al."Stathmin genotype is associated with reexperiencing symptoms of posttraumatic stress disorder in Chinese earthquake survivors".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 44(2013):296-300.
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