The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala

	The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
	Long, Haixia; Liu, Bing; Hou, Bing; Wang, Chao; Li, Jin; Qin, Wen; Wang, Dawei; Zhou, Yuan; Kendrick, Keith M.; Yu, Chunshui; Jiang, Tianzi; Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
心理所单位排序	4
摘要	The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.
关键词	5-HTTLPR functional and anatomical connectivity amygdala prefrontal cortex Han Chinese
学科领域	Physiological Psychology/biological Psychology,Emotional Psychology
	2013
语种	英语
发表期刊	NEUROSCIENCE BULLETIN
ISSN	0304-3940
卷号	29 期号:1 页码:4-15
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This work was partly supported by the National Key Basic Research and Development Program (973) (2011CB707800), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02030300), the Natural Science Foundation of China (91132301 and 81000582), and the Beijing Nova Program (2010B06).
WOS记录号	WOS:000314298300003
资助机构	National Key Basic Research and Development Program (973) [2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02030300] ; Natural Science Foundation of China [91132301, 81000582] ; Beijing Nova Program [2010B06]
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/10673
专题	中国科学院行为科学重点实验室
通讯作者	Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
作者单位	Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Long, Haixia,Liu, Bing,Hou, Bing,et al. The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala[J]. NEUROSCIENCE BULLETIN,2013,29(1):4-15.
APA	Long, Haixia.,Liu, Bing.,Hou, Bing.,Wang, Chao.,Li, Jin.,...&Jiang, TZ .(2013).The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.NEUROSCIENCE BULLETIN,29(1),4-15.
MLA	Long, Haixia,et al."The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala".NEUROSCIENCE BULLETIN 29.1(2013):4-15.

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