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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
Long, Haixia; Liu, Bing; Hou, Bing; Wang, Chao; Li, Jin; Qin, Wen; Wang, Dawei; Zhou, Yuan; Kendrick, Keith M.; Yu, Chunshui; Jiang, Tianzi; Jiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
2013
Source PublicationNEUROSCIENCE BULLETIN
ISSN0304-3940
Subtype期刊论文
Volume29Issue:1Pages:4-15
Contribution Rank4
AbstractThe short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.
Keyword5-HTTLPR functional and anatomical connectivity amygdala prefrontal cortex Han Chinese
Subject AreaPhysiological Psychology/biological Psychology,Emotional Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973) [2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02030300] ; Natural Science Foundation of China [91132301, 81000582] ; Beijing Nova Program [2010B06]
Project Intro.This work was partly supported by the National Key Basic Research and Development Program (973) (2011CB707800), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02030300), the Natural Science Foundation of China (91132301 and 81000582), and the Beijing Nova Program (2010B06).
WOS IDWOS:000314298300003
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Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10673
Collection中国科学院行为科学重点实验室
Corresponding AuthorJiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
AffiliationJiang, TZ (reprint author), Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Long, Haixia,Liu, Bing,Hou, Bing,et al. The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala[J]. NEUROSCIENCE BULLETIN,2013,29(1):4-15.
APA Long, Haixia.,Liu, Bing.,Hou, Bing.,Wang, Chao.,Li, Jin.,...&Jiang, TZ .(2013).The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.NEUROSCIENCE BULLETIN,29(1),4-15.
MLA Long, Haixia,et al."The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala".NEUROSCIENCE BULLETIN 29.1(2013):4-15.
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