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Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats
Yang, Yuan-Xiao1; Chen, Yi-Tao1; Zhou, Xiao-Jie1; Hong, Chun-Lan1; Li, Chang-Yu1; Guo, Jian-You2; Li, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
2013
发表期刊BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1472-6882
文章类型期刊论文
卷号13
产权排序2
摘要Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. beta-Asarone, which has significant pharmacological effects on the central nervous system (CNS), was used in the prevention of cerebral ischemia in this paper. Methods: The right middle cerebral artery occlusion model was used in the study. The effects of beta-Asarone on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+- K+-ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results: beta-Asarone significantly improved the neurological outcome after cerebral ischemia and reperfusion in terms of neurobehavioral function in rats. Meanwhile, supplementation of beta-Asarone significantly boosted the defense mechanism against cerebral ischemia via increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may help the brain recover from ischemic injury. Conclusions: These experimental results suggest that complement beta-Asarone is protective against cerebral ischemia in specific way. The administration of beta-Asarone could reduce focal cerebral ischemic/reperfusion injury. The Mechanism of beta-Asarone in protection of cerebral ischemia was via increasing antioxidants activity related to lesion pathogenesis.
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Zhejiang Key Technology Innovation Team [2012R10044-08] ; Zhejiang Science and Technology [2007C23021] ; Zhejiang Province Natural Science Foundation [LQ13H280003]
项目简介This work was supported by grants from the Zhejiang Key Technology Innovation Team (2012R10044-08), the Program of the Zhejiang Science and Technology (2007C23021) and the Program of the Zhejiang Province Natural Science Foundation (LQ13H280003).
WOS记录号WOS:000328213200001
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10674
专题中国科学院心理健康重点实验室
通讯作者Li, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
作者单位1.Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Yang, Yuan-Xiao,Chen, Yi-Tao,Zhou, Xiao-Jie,et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13.
APA Yang, Yuan-Xiao.,Chen, Yi-Tao.,Zhou, Xiao-Jie.,Hong, Chun-Lan.,Li, Chang-Yu.,...&Li, CY .(2013).Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA Yang, Yuan-Xiao,et al."Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013).
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