PSYCH OpenIR  > 中国科学院心理健康重点实验室
Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats
Yang, Yuan-Xiao1; Chen, Yi-Tao1; Zhou, Xiao-Jie1; Hong, Chun-Lan1; Li, Chang-Yu1; Guo, Jian-You2; Li, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
2013
Source PublicationBMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1472-6882
Subtype期刊论文
Volume13
Contribution Rank2
AbstractBackground: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. beta-Asarone, which has significant pharmacological effects on the central nervous system (CNS), was used in the prevention of cerebral ischemia in this paper. Methods: The right middle cerebral artery occlusion model was used in the study. The effects of beta-Asarone on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+- K+-ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results: beta-Asarone significantly improved the neurological outcome after cerebral ischemia and reperfusion in terms of neurobehavioral function in rats. Meanwhile, supplementation of beta-Asarone significantly boosted the defense mechanism against cerebral ischemia via increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may help the brain recover from ischemic injury. Conclusions: These experimental results suggest that complement beta-Asarone is protective against cerebral ischemia in specific way. The administration of beta-Asarone could reduce focal cerebral ischemic/reperfusion injury. The Mechanism of beta-Asarone in protection of cerebral ischemia was via increasing antioxidants activity related to lesion pathogenesis.
Subject AreaMedical Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationZhejiang Key Technology Innovation Team [2012R10044-08] ; Zhejiang Science and Technology [2007C23021] ; Zhejiang Province Natural Science Foundation [LQ13H280003]
Project Intro.This work was supported by grants from the Zhejiang Key Technology Innovation Team (2012R10044-08), the Program of the Zhejiang Science and Technology (2007C23021) and the Program of the Zhejiang Province Natural Science Foundation (LQ13H280003).
WOS IDWOS:000328213200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10674
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
Affiliation1.Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yuan-Xiao,Chen, Yi-Tao,Zhou, Xiao-Jie,et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13.
APA Yang, Yuan-Xiao.,Chen, Yi-Tao.,Zhou, Xiao-Jie.,Hong, Chun-Lan.,Li, Chang-Yu.,...&Li, CY .(2013).Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA Yang, Yuan-Xiao,et al."Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013).
Files in This Item:
File Name/Size DocType Version Access License
WOS000328213200001.p(249KB) 限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Yuan-Xiao]'s Articles
[Chen, Yi-Tao]'s Articles
[Zhou, Xiao-Jie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Yuan-Xiao]'s Articles
[Chen, Yi-Tao]'s Articles
[Zhou, Xiao-Jie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Yuan-Xiao]'s Articles
[Chen, Yi-Tao]'s Articles
[Zhou, Xiao-Jie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000328213200001.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.