Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats

	Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats
	Yang, Yuan-Xiao 1; Chen, Yi-Tao 1; Zhou, Xiao-Jie 1; Hong, Chun-Lan 1; Li, Chang-Yu 1; Guo, Jian-You2 ; Li, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
心理所单位排序	2
摘要	Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. beta-Asarone, which has significant pharmacological effects on the central nervous system (CNS), was used in the prevention of cerebral ischemia in this paper. Methods: The right middle cerebral artery occlusion model was used in the study. The effects of beta-Asarone on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+- K+-ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results: beta-Asarone significantly improved the neurological outcome after cerebral ischemia and reperfusion in terms of neurobehavioral function in rats. Meanwhile, supplementation of beta-Asarone significantly boosted the defense mechanism against cerebral ischemia via increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may help the brain recover from ischemic injury. Conclusions: These experimental results suggest that complement beta-Asarone is protective against cerebral ischemia in specific way. The administration of beta-Asarone could reduce focal cerebral ischemic/reperfusion injury. The Mechanism of beta-Asarone in protection of cerebral ischemia was via increasing antioxidants activity related to lesion pathogenesis.
学科领域	Medical Psychology
	2013
语种	英语
发表期刊	BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1472-6882
卷号	13
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This work was supported by grants from the Zhejiang Key Technology Innovation Team (2012R10044-08), the Program of the Zhejiang Science and Technology (2007C23021) and the Program of the Zhejiang Province Natural Science Foundation (LQ13H280003).
WOS记录号	WOS:000328213200001
资助机构	Zhejiang Key Technology Innovation Team [2012R10044-08] ; Zhejiang Science and Technology [2007C23021] ; Zhejiang Province Natural Science Foundation [LQ13H280003]
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10674
专题	中国科学院心理健康重点实验室
通讯作者	Li, CY (reprint author), Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
作者单位	1.Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yuan-Xiao,Chen, Yi-Tao,Zhou, Xiao-Jie,et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13.
APA	Yang, Yuan-Xiao.,Chen, Yi-Tao.,Zhou, Xiao-Jie.,Hong, Chun-Lan.,Li, Chang-Yu.,...&Li, CY .(2013).Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA	Yang, Yuan-Xiao,et al."Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS000328213200001.p（249KB）			限制开放	CC BY-NC-SA	请求全文