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Toward reliable characterization of functional homogeneity in the human brain: Preprocessing, scan duration, imaging resolution and computational space
Zuo, Xi-Nian; Xu, Ting; Jiang, Lili; Yang, Zhi; Cao, Xiao-Yan; He, Yong; Zang, Yu-Feng; Castellanos, F. Xavier; Milham, Michael P.; Zuo, XN (reprint author), 4A Datun Rd, Beijing 100101, Peoples R China.
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AbstractWhile researchers have extensively characterized functional connectivity between brain regions, the characterization of functional homogeneity within a region of the brain connectome is in early stages of development. Several functional homogeneity measures were proposed previously, among which regional homogeneity (ReHo) was most widely used as a measure to characterize functional homogeneity of resting state fMRI (R-fMRI) signals within a small region (Zang et al., 2004). Despite a burgeoning literature on ReHo in the field of neuroimaging brain disorders, its test-retest (TRT) reliability remains unestablished. Using two sets of public R-fMRI TRT data, we systematically evaluated the ReHo's TRT reliability and further investigated the various factors influencing its reliability and found: 1) nuisance (head motion, white matter, and cerebrospinal fluid) correction of R-fMRI time series can significantly improve the TRT reliability of ReHo while additional removal of global brain signal reduces its reliability, 2) spatial smoothing of R-fMRI time series artificially enhances ReHo intensity and influences its reliability, 3) surface-based R-fMRI computation largely improves the TRT reliability of ReHo, 4) a scan duration of 5 min can achieve reliable estimates of ReHo, and 5) fast sampling rates of R-fMRI dramatically increase the reliability of ReHo. Inspired by these findings and seeking a highly reliable approach to exploratory analysis of the human functional connectome, we established an R-fMRI pipeline to conduct ReHo computations in both 3-dimensions (volume) and 2-dimensions (surface). (C) 2012 Elsevier Inc. All rights reserved.
KeywordConnectome Test-retest Reliability Functional homogeneity Default network
Subject AreaCognitive Neuroscience
2013
Language英语
Source PublicationNEUROIMAGE
ISSN1053-8119
Volume65Pages:374-386
Subtype期刊论文
URL查看原文
Indexed BySCI
Project Intro.This work was partially supported by the National Natural Science Foundation of China (81220108014, 81171409, 81030028) the Open Research Fund of the Key Laboratory of Behavioral Science and the Startup Foundation for Distinguished Research Professor (Y0CX492S03) of the Institute of Psychology, Chinese Academy of Sciences as well as R01MH083246 from NIMH. We thank Caitlin Hinz and Ting-Ting Cheng for their contribution of language editing, and Qing-Yang Li for his coordination of the fast imaging data. We also thank Dr. Chao-Gan Yan for valuable discussions on headmotion and Dr. Thomas Yea for his insightful guidance on surface data processing and quality control.
WOS IDWOS:000312283900034
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Cited Times:272[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10675
Collection中国科学院行为科学重点实验室
Corresponding AuthorZuo, XN (reprint author), 4A Datun Rd, Beijing 100101, Peoples R China.
AffiliationZuo, XN (reprint author), 4A Datun Rd, Beijing 100101, Peoples R China.
Recommended Citation
GB/T 7714
Zuo, Xi-Nian,Xu, Ting,Jiang, Lili,et al. Toward reliable characterization of functional homogeneity in the human brain: Preprocessing, scan duration, imaging resolution and computational space[J]. NEUROIMAGE,2013,65:374-386.
APA Zuo, Xi-Nian.,Xu, Ting.,Jiang, Lili.,Yang, Zhi.,Cao, Xiao-Yan.,...&Zuo, XN .(2013).Toward reliable characterization of functional homogeneity in the human brain: Preprocessing, scan duration, imaging resolution and computational space.NEUROIMAGE,65,374-386.
MLA Zuo, Xi-Nian,et al."Toward reliable characterization of functional homogeneity in the human brain: Preprocessing, scan duration, imaging resolution and computational space".NEUROIMAGE 65(2013):374-386.
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