PSYCH OpenIR  > 中国科学院心理健康重点实验室
BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder
Chang, Su-Hua1; Gao, Lei1,2; Li, Zhao1,2; Zhang, Wei-Na1,2; Du, Yang1,2; Wang, Jing1; Wang, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊BIOLOGICAL PSYCHIATRY
ISSN0006-3223
文章类型期刊论文
卷号74期号:10页码:727-733
产权排序1
摘要Background: Bipolar disorder (BD) is a common psychiatric disorder with complex genetic architecture. It shares overlapping genetic influences with schizophrenia (SZ) and major depressive disorder (MDD). Large numbers of genetic studies of BD and cross-disorder studies between BD and SZ/MDD have accumulated numerous genetic data. There is a growing need to integrate the data to provide a comprehensive data set to facilitate the genetic study of BD and its highly relevant diseases. Methods: BDgene database was developed to integrate BD-related genetic factors and shared ones with SZ/MDD from profound literature reading. On the basis of data from the literature, in-depth analyses were performed for further understanding of the data, including gene prioritization, pathway-based analysis, intersection analysis of multidisease candidate genes, and pathway enrichment analysis. Results: BDgene includes multiple types of literature-reported genetic factors of BD with both positive and negative results, including 797 genes, 3119 single nucleotide polymorphisms, and 789 regions. Shared genetic factors such as single nucleotide polymorphisms, genes, and regions from published cross-disorder studies among BD and SZ/MDD were also presented. In-depth data analyses identified 43 BD core genes; 70 BD candidate pathways; and 127, 79, and 107 new potential cross-disorder genes for BD-SZ, BD-MDD, and BD-SZ-MDD, respectively. Conclusions: As a central genetic database for BD and the first cross-disorder database for BD and SZ/MDD, BDgene provides not only a comprehensive review of current genetic research but also high-confidence candidate genes and pathways for understanding of BD mechanism and shared etiology among its relevant diseases. BDgene is freely available at http://bdgene.psych.ac.cn.
关键词BDgene bipolar disorder data analysis genetic database genetic overlap major depressive disorder schizophrenia
学科领域Abnormal Psychology,health Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者State Administration of Foreign Experts Affairs of Chinese Academy of Sciences (CAS/SAFEA) International Partnership Program for Creative Research Teams [Y2CX131003] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This work was supported by the State Administration of Foreign Experts Affairs of Chinese Academy of Sciences (CAS/SAFEA) International Partnership Program for Creative Research Teams (Grant No. Y2CX131003), the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KSCX2-EW-J-8), and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. We thank Dr. Kun-Lin Zhang for his valuable suggestions on parameter selection of pathway-based analysis for genome-wide association studies.
WOS记录号WOS:000325972700012
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10676
专题中国科学院心理健康重点实验室
通讯作者Wang, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chang, Su-Hua,Gao, Lei,Li, Zhao,et al. BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder[J]. BIOLOGICAL PSYCHIATRY,2013,74(10):727-733.
APA Chang, Su-Hua.,Gao, Lei.,Li, Zhao.,Zhang, Wei-Na.,Du, Yang.,...&Wang, J .(2013).BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder.BIOLOGICAL PSYCHIATRY,74(10),727-733.
MLA Chang, Su-Hua,et al."BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder".BIOLOGICAL PSYCHIATRY 74.10(2013):727-733.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000325972700012.p(806KB) 限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Su-Hua]的文章
[Gao, Lei]的文章
[Li, Zhao]的文章
百度学术
百度学术中相似的文章
[Chang, Su-Hua]的文章
[Gao, Lei]的文章
[Li, Zhao]的文章
必应学术
必应学术中相似的文章
[Chang, Su-Hua]的文章
[Gao, Lei]的文章
[Li, Zhao]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000325972700012.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。