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BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder
Chang, Su-Hua1; Gao, Lei1,2; Li, Zhao1,2; Zhang, Wei-Na1,2; Du, Yang1,2; Wang, Jing1; Wang, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
Source PublicationBIOLOGICAL PSYCHIATRY
ISSN0006-3223
Subtype期刊论文
Volume74Issue:10Pages:727-733
Contribution Rank1
AbstractBackground: Bipolar disorder (BD) is a common psychiatric disorder with complex genetic architecture. It shares overlapping genetic influences with schizophrenia (SZ) and major depressive disorder (MDD). Large numbers of genetic studies of BD and cross-disorder studies between BD and SZ/MDD have accumulated numerous genetic data. There is a growing need to integrate the data to provide a comprehensive data set to facilitate the genetic study of BD and its highly relevant diseases. Methods: BDgene database was developed to integrate BD-related genetic factors and shared ones with SZ/MDD from profound literature reading. On the basis of data from the literature, in-depth analyses were performed for further understanding of the data, including gene prioritization, pathway-based analysis, intersection analysis of multidisease candidate genes, and pathway enrichment analysis. Results: BDgene includes multiple types of literature-reported genetic factors of BD with both positive and negative results, including 797 genes, 3119 single nucleotide polymorphisms, and 789 regions. Shared genetic factors such as single nucleotide polymorphisms, genes, and regions from published cross-disorder studies among BD and SZ/MDD were also presented. In-depth data analyses identified 43 BD core genes; 70 BD candidate pathways; and 127, 79, and 107 new potential cross-disorder genes for BD-SZ, BD-MDD, and BD-SZ-MDD, respectively. Conclusions: As a central genetic database for BD and the first cross-disorder database for BD and SZ/MDD, BDgene provides not only a comprehensive review of current genetic research but also high-confidence candidate genes and pathways for understanding of BD mechanism and shared etiology among its relevant diseases. BDgene is freely available at http://bdgene.psych.ac.cn.
KeywordBDgene bipolar disorder data analysis genetic database genetic overlap major depressive disorder schizophrenia
Subject AreaAbnormal Psychology,health Psychology
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Indexed BySCI
Language英语
Funding OrganizationState Administration of Foreign Experts Affairs of Chinese Academy of Sciences (CAS/SAFEA) International Partnership Program for Creative Research Teams [Y2CX131003] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.This work was supported by the State Administration of Foreign Experts Affairs of Chinese Academy of Sciences (CAS/SAFEA) International Partnership Program for Creative Research Teams (Grant No. Y2CX131003), the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KSCX2-EW-J-8), and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. We thank Dr. Kun-Lin Zhang for his valuable suggestions on parameter selection of pathway-based analysis for genome-wide association studies.
WOS IDWOS:000325972700012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10676
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chang, Su-Hua,Gao, Lei,Li, Zhao,et al. BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder[J]. BIOLOGICAL PSYCHIATRY,2013,74(10):727-733.
APA Chang, Su-Hua.,Gao, Lei.,Li, Zhao.,Zhang, Wei-Na.,Du, Yang.,...&Wang, J .(2013).BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder.BIOLOGICAL PSYCHIATRY,74(10),727-733.
MLA Chang, Su-Hua,et al."BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder".BIOLOGICAL PSYCHIATRY 74.10(2013):727-733.
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