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The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study
Chen, Jie; Li, Xinying; McGue, Matt; Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
ISSN0021-9630
文章类型期刊论文
卷号54期号:10页码:1066-1073
产权排序1
摘要BackgroundConfounding introduced by gene-environment correlation (rGE) may prevent one from observing a true gene-environment interaction (GxE) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. MethodsA total of 780 pairs of Chinese twins, aged 11-17years (mean=13.6, SD=1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. ResultsAfter controlling for sex, age, age square, and Time 1 depression, both total SLEs x BDNF Val66Met genotype and independent SLEs x BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. ConclusionsThere is a true GxE effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression.
关键词Adolescent depressive symptoms BDNF Val66Met polymorphism stressful life events gene-environment interaction gene-environment correlation
学科领域Personality Psychology,Developmental Psychology
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收录类别SCI
语种英语
项目资助者Chinese Academy of Sciences [KSCX2-EW-J-8] ; Funds for young scholars of Institute of Psychology, Chinese Academy of Science [Y0CX351S01] ; National Natural Science Foundation of China [31170993] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This study was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), Funds for young scholars of Institute of Psychology, Chinese Academy of Science (Y0CX351S01), and the National Natural Science Foundation of China (31170993). This research was also supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号WOS:000326177200006
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10681
专题中国科学院心理健康重点实验室
通讯作者Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
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GB/T 7714
Chen, Jie,Li, Xinying,McGue, Matt,et al. The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study[J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,2013,54(10):1066-1073.
APA Chen, Jie,Li, Xinying,McGue, Matt,&Li, XY .(2013).The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study.JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,54(10),1066-1073.
MLA Chen, Jie,et al."The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study".JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 54.10(2013):1066-1073.
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