PSYCH OpenIR  > 中国科学院行为科学重点实验室
Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease
Wang, Jinhui1; Zuo, Xinian2; Dai, Zhengjia1; Xia, Mingrui1; Zhao, Zhilian3; Zhao, Xiaoling4; Jia, Jianping4; Han, Ying4; He, Yong1; He, Y (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwai St, Beijing 100875, Peoples R China.
2013
发表期刊BIOLOGICAL PSYCHIATRY
ISSN0006-3223
文章类型期刊论文
卷号73期号:5页码:472-481
产权排序3
摘要Background: Alzheimer's disease disrupts the topological architecture of whole-brain connectivity (i.e., the connectome); however, whether this disruption is present in amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer's disease, remains largely unknown. Methods: We employed resting-state functional magnetic resonance imaging and graph theory approaches to systematically investigate the topological organization of the functional connectome of 37 patients with aMCI and 47 healthy control subjects. Frequency-dependent brain networks were derived from wavelet-based correlations of both high-and low-resolution parcellation units. Results: In the frequency interval .031-.063 Hz, the aMCI patients showed an overall decreased functional connectivity of their brain connectome compared with control subjects. Further graph theory analyses of this frequency band revealed an increased path length of the connectome in the aMCI group. Moreover, the disease targeted several key nodes predominantly in the default-mode regions and key links primarily in the intramodule connections within the default-mode network and the intermodule connections among different functional systems. Intriguingly, the topological aberrations correlated with the patients' memory performance and differentiated individuals with aMCI from healthy elderly individuals with a sensitivity of 86.5% and a specificity of 85.1%. Finally, we demonstrated a high reproducibility of our findings across different large-scale parcellation schemes and validated the test-retest reliability of our network-based approaches. Conclusions: This study demonstrates a disruption of whole-brain topological organization of the functional connectome in aMCI. Our finding provides novel insights into the pathophysiological mechanism of aMCI and highlights the potential for using connectome-based metrics as a disease biomarker.
关键词Connectivity connectomics default-mode MCI modularity small-world
学科领域Psychology Of Old Age
URL查看原文
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China [81030028, 30970823, 81171409] ; Beijing Natural Science Foundation [7102090, Z111107067311036] ; Startup Foundation for Distinguished Research Professor of Institute of Psychology, Chinese Academy of Sciences [Y0CX492S03]
项目简介This work was supported by the Natural Science Foundation of China (Grant numbers 81030028, 30970823, and 81171409), Beijing Natural Science Foundation (Grant number 7102090, Z111107067311036), and the Startup Foundation for Distinguished Research Professor of Institute of Psychology, Chinese Academy of Sciences (Y0CX492S03, XNZ).
WOS记录号WOS:000314634900013
引用统计
被引频次:170[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10684
专题中国科学院行为科学重点实验室
通讯作者He, Y (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, 19 Xinjiekouwai St, Beijing 100875, Peoples R China.
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Lab Funct Connectome & Dev,Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jinhui,Zuo, Xinian,Dai, Zhengjia,et al. Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease[J]. BIOLOGICAL PSYCHIATRY,2013,73(5):472-481.
APA Wang, Jinhui.,Zuo, Xinian.,Dai, Zhengjia.,Xia, Mingrui.,Zhao, Zhilian.,...&He, Y .(2013).Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease.BIOLOGICAL PSYCHIATRY,73(5),472-481.
MLA Wang, Jinhui,et al."Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease".BIOLOGICAL PSYCHIATRY 73.5(2013):472-481.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000314634900013.(1106KB) 开放获取Apache License请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jinhui]的文章
[Zuo, Xinian]的文章
[Dai, Zhengjia]的文章
百度学术
百度学术中相似的文章
[Wang, Jinhui]的文章
[Zuo, Xinian]的文章
[Dai, Zhengjia]的文章
必应学术
必应学术中相似的文章
[Wang, Jinhui]的文章
[Zuo, Xinian]的文章
[Dai, Zhengjia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。