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Ten-a Affects Fusion of Central Complex Primordia in Drosophila
Cheng, Xuebo1,2; Jiang, Huoqing1; Li, Weizhe1; Lv, Hailong1; Gong, Zhefeng1,3; Liu, Li1,4
Source PublicationPLOS ONE
AbstractThe central complex of Drosophila melanogaster plays important functions in various behaviors, such as visual and olfactory memory, visual orientation, sleep, and movement control. However little is known about the genes regulating the development of the central complex. Here we report that a mutant gene affecting central complex morphology, cbd (central brain defect), was mapped to ten-a, a type II trans-membrane protein coding gene. Down-regulation of ten-a in pan-neural cells contributed to abnormal morphology of central complex. Over-expression of ten-a by C767-Gal4 was able to partially restore the abnormal central complex morphology in the cbd mutant. Tracking the development of FB primordia revealed that C767-Gal4 labeled interhemispheric junction that separated fan-shaped body precursors at larval stage withdrew to allow the fusion of the precursors. While the C767-Gal4 labeled structure did not withdraw properly and detached from FB primordia, the two fan-shaped body precursors failed to fuse in the cbd mutant. We propose that the withdrawal of C767-Gal4 labeled structure is related to the formation of the fan-shaped body. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation.
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000315184200221
WOS HeadingsScience & Technology
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Zhejiang Univ, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
4.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,et al. Ten-a Affects Fusion of Central Complex Primordia in Drosophila[J]. PLOS ONE,2013,8(2):1-11.
APA Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,Lv, Hailong,Gong, Zhefeng,&Liu, Li.(2013).Ten-a Affects Fusion of Central Complex Primordia in Drosophila.PLOS ONE,8(2),1-11.
MLA Cheng, Xuebo,et al."Ten-a Affects Fusion of Central Complex Primordia in Drosophila".PLOS ONE 8.2(2013):1-11.
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