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COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
Sachdev, Perminder S.1,2; Lipnicki, Darren M.1; Kochan, Nicole A.1; Crawford, John D.1; Rockwood, Kenneth3; Xiao, Shifu4; Li, Juan5; Li, Xia4; Brayne, Carol6; Matthews, Fiona E.7; Stephan, Blossom C. M.8; Lipton, Richard B.9,10; Katz, Mindy J.9; Ritchie, Karen11,12,13; Carriere, Isabelle11,12; Ancelin, Marie-Laure11,12; Seshadri, Sudha14; Au, Rhoda14; Beiser, Alexa S.15; Lam, Linda C. W.16; Wong, Candy H. Y.17; Fung, Ada W. T.16; Kim, Ki Woong18,19,20; Han, Ji Won18; Kim, Tae Hui18; Petersen, Ronald C.21; Roberts, Rosebud O.21; Mielke, Michelle M.21; Ganguli, Mary22,23,24; Dodge, Hiroko H.25,26; Hughes, Tiffany22; Anstey, Kaarin J.27; Cherbuin, Nicolas27; Butterworth, Peter27; Ng, Tze Pin28; Gao, Qi28; Reppermund, Simone1; Brodaty, Henry1,2; Meguro, Kenichi29; Schupf, Nicole30,31,32; Manly, Jennifer30,31,33; Stern, Yaakov30,31,33; Lobo, Antonio34,35,36; Lopez-Anton, Raul35,37; Santabarbara, Javier35,38; COSMIC; Sachdev, PS (reprint author), Univ New S Wales, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
2013
发表期刊BMC NEUROLOGY
ISSN1471-2377
文章类型期刊论文
卷号13
产权排序5
摘要Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders. Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.
关键词Cohort studies Cognitive ageing Data harmonisation Dementia International consortium Mild cognitive impairment
学科领域Psychology Of Old Age
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收录类别SCI
语种英语
项目资助者National Health Research Development Program of Health Canada [6605-3954-MC[S]] ; China Ministry of Science and Technology [2009BAI77B03] ; National Institute on Health/National Institute on Aging [5P01 AG003949, 1R03 AG045474] ; Novartis ; National Heart, Lung and Blood Institute's Framingham Heart Study [N01-HC-25195] ; National Institute of Aging [AG08122, AG16495, AG033193] ; National Institute of Neurological Disorders and Stroke [NS17950] ; National Heart, Lung and Blood Association [HL93029, U01HL 096917] ; Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund ; Eisai ; Ministry for Health, Welfare, & Family Affairs, Republic of Korea [A092077] ; National Institute on Aging [U01 AG006786, P50 AG016574, R01 AG034676] ; National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services [R01AG07562] ; National Health and Medical Research Council of Australia [973302, 179805, 157125, 1002160] ; Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore [03/121/17/214, 08/1/21/19/567] ; National Health & Medical Research Council of Australia Program Grant [350833] ; National Institute of Health/National Institute on Aging [R01 AG037212, P01 AG07232] ; Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain [94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, G03/128] ; Pfizer Foundation, Madrid
项目简介Canadian Study of Health and Aging (CSHA): Kenneth Rockwood (study leader). Funding from the National Health Research Development Program of Health Canada (6605-3954-MC[S]).Chinese Longitudinal Ageing Study (CLAS): Shifu Xiao (study leader), Juan Li, Xia Li. The authors extend their thanks to the main investigators from across the different regions of China: Tao Wang, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yaping Wang, Yefeng Yuan, Xiaoyun Zuo, Zhongming Chen, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Mingyuan Zhang. Funding from a China Ministry of Science and Technology grant (2009BAI77B03).Cognitive Function and Ageing Studies (CFAS): Carol Brayne (study leader), Fiona E Matthews, Blossom CM Stephan. Funding from major awards from the Medical Research Council and the Department of Health, UK. Einstein Aging Study (EAS): Richard B Lipton (study leader), Mindy J Katz (study leader). The authors acknowledge the contributions of Molly Zimmerman and Carol Derby. Funding from National Institute on Health/National Institute on Aging grants: 5P01 AG003949, 1R03 AG045474. Etude Sante Psychologique Prevalence Risques et Traitement (ESPRIT): Karen Ritchie (study leader), Isabelle Carriere, Marie-Laure Ancelin (study leader). Funding from Novartis.Framingham Heart Study (FHS): Sudha Seshadri (study leader), Rhoda Au, Alexa S Beiser. The authors acknowledge the contributions of Philip A. Wolf and Galit A. Weinstein, and the dedication of the FHS participants. Funding from the National Heart, Lung and Blood Institute's Framingham Heart Study (Contract No. N01-HC-25195) and grants from the National Institute of Aging (AG08122, AG16495, AG033193), the National Institute of Neurological Disorders and Stroke (NS17950), and the National Heart, Lung and Blood Association (HL93029, U01HL 096917). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Heart Lung and Blood Institute, the National Institute of Aging or the National Institutes of Health.Hong Kong Memory and Ageing Prospective Study (HK-MAPS): Linda CW Lam (study leader), Candy HY Wong, Ada WT Fung. The authors acknowledge the contributions of Grace T. Y. Leung, Wai Chi Chan, Department of Health of Hong Kong SAR, the participants and the social centers for their assistance in the assessment, and thank Novartis and Astra Zeneca for their sponsorship of souvenirs for the participants in the baseline study. The baseline study is funded in part by the Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and by an educational fund from Eisai.Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD): Ki Woong Kim (study leader), Ji Won Han, Tae Hui Kim. Funding from a Korean Health Technology R& D Project grant from the Ministry for Health, Welfare, & Family Affairs, Republic of Korea (Grant No. A092077).Mayo Clinic Study of Aging (MCSA): Ronald C Petersen (study leader), Rosebud O Roberts, Michelle M Mielke. Funding from the National Institute on Aging: U01 AG006786, P50 AG016574, R01 AG034676.Monongahela Valley Independent Elders Survey (MoVIES): Mary Ganguli (study leader), Hiroko H Dodge, Tiffany Hughes. The authors acknowledge the contributions of 1681 study participants from the Monongahela Valley and of multiple MoVIES project personnel over the years. Funding from Grant # R01AG07562 from the National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services.Personality and Total Health (PATH) Through Life Project: Kaarin J Anstey (study leader), Nicolas Cherbuin, Peter Butterworth. The authors acknowledge the further study members Helen Christensen, Andrew MacKinnon, Simon Easteal, Project Managers Trish Jacomb, Karen Maxwell, participants and the NHMRC. Funding from National Health and Medical Research Council of Australia grants 973302, 179805, 157125 and 1002160.Funding from research grants (No. 03/121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore.Sydney Memory and Ageing Study (MAS): Perminder S Sachdev (study leader and consortium head), Darren M Lipnicki, Nicole A Kochan, John D Crawford, Simone Reppermund, Henry Brodaty (study leader). The authors acknowledge the contributions of members of the MAS Team: Allison Bowman, Kim Burns, Anthony Broe, Joula Dekker, Louise Dooley, Michele de Permentier, Sarah Fairjones, Janelle Fletcher, Therese French, Cathy Foster, Emma Nugent-Cleary-Fox, Chien Gooi, Evelyn Harvey, Rebecca Helyer, Sharpley Hsieh, Laura Hughes, Sarah Jacek, Mary Johnston, Donna McCade, Samantha Meeth, Eveline Milne, Angharad Moir, Ros O'Grady, Kia Pfaeffli, Carine Pose, Laura Reuser, Amanda Rose, Peter Schofield, Zeeshan Shahnawaz, Amanda Sharpley, Claire Thompson, Wiebke Queisser, and Sam Wong. Funding from a National Health & Medical Research Council of Australia Program Grant (ID 350833).Tajiri Project: Kenichi Meguro (study leader). The author acknowledges the contributions of Mari Kasai, Kei Nakamura, and Masahiro Nakatsuka. Washington Heights Inwood and Columbia Aging Project (WHICAP): Nicole Schupf (study leader), Jennifer Manly, Yaakov Stern. The authors acknowledge the contributions of Richard Mayeux, Principal Investigator of the WHICAP study, co-investigators Adam Brickman and Jose Luchsinger, and study team members Danurys Sanchez, Ming X. Tang and Howard Andrews. Funding from the National Institute of Health/National Institute on Aging: Grants # R01 AG037212, P01 AG07232.ZARADEMP Project (ZARAgoza DEMentia DEPression Project): Antonio Lobo (study leader), Ra l Lopez-Anton, Javier Santabarbara. The authors acknowledge the further study members Guillermo Marcos, Concepcion De-la-Camara, Pedro Saz, Tirso Ventura, Miguel Angel Quintanilla, and Elena Lobo, and the contributions of the ZARADEMP Workgroup who participated in the study. Funding from the Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid.
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology
WOS记录号WOS:000329060600002
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]IMPAIRMENT ; PROJECT ; PREVALENCE ; COMMUNITY ; POPULATION ; FRAMINGHAM ; PROFILE ; DESIGN ; PREVENTION ; SINGAPORE
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10702
专题健康与遗传心理学研究室
通讯作者Sachdev, PS (reprint author), Univ New S Wales, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
作者单位1.Univ New S Wales, Ctr Hlth Brain Ageing, Sydney, NSW, Australia
2.Univ New S Wales, Dementia Collaborat Res Ctr, Sydney, NSW, Australia
3.Dalhousie Univ, Dept Med Geriatr Med & Neurol, Halifax, NS, Canada
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept Geriatr Psychiat, Shanghai, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England
7.Inst Publ Hlth, MRC Biostat Unit, Cambridge, England
8.Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
9.Yeshiva Univ, Albert Einstein Coll Med, Saul R Korey Dept Neurol, New York, NY 10033 USA
10.Yeshiva Univ, Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY 10033 USA
11.La Colombiere Hosp, INSERM, Nervous Syst Pathologies: Epidemiol & Clin Res U1, Montpellier 5, France
12.Univ Montpellier I, Montpellier, France
13.Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Fac Med, London, England
14.Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
15.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
16.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
17.Tai Po Hosp, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
18.Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, South Korea
19.Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea
20.Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul 151742, South Korea
21.Mayo Clin, Coll Med, Rochester, MN USA
22.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
23.Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
24.Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA
25.Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA
26.Univ Michigan, Dept Neurol, Ann Arbor, MI USA
27.Australian Natl Univ, Coll Med Biol & Environm, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia
28.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Gerontol Res Programme, Singapore 117595, Singapore
29.Tohoku Univ, Grad Sch Med, Dept Geriatr Behav Neurol, Sendai, Miyagi 980, Japan
30.Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA
31.Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA
32.Columbia Univ, Joseph P Mailman Sch Publ Hlth, Div Epidemiol, New York, NY USA
33.Columbia Univ, Dept Neurol, New York, NY USA
34.Univ Zaragoza, Dept Med & Psychiat, Zaragoza, Spain
35.Minist Sci & Innovat, CIBERSAM, Madrid, Spain
36.IIS Aragon, Zaragoza, Spain
37.Univ Zaragoza, Dept Psychol & Sociol, Zaragoza, Spain
38.Univ Zaragoza, Dept Prevent Med & Publ Hlth, Zaragoza, Spain
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GB/T 7714
Sachdev, Perminder S.,Lipnicki, Darren M.,Kochan, Nicole A.,et al. COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups[J]. BMC NEUROLOGY,2013,13.
APA Sachdev, Perminder S..,Lipnicki, Darren M..,Kochan, Nicole A..,Crawford, John D..,Rockwood, Kenneth.,...&Sachdev, PS .(2013).COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.BMC NEUROLOGY,13.
MLA Sachdev, Perminder S.,et al."COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups".BMC NEUROLOGY 13(2013).
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