PSYCH OpenIR  > 中国科学院心理健康重点实验室
Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis
Feng, Min1,2,3; Sui, Nan1; Li, Ming2; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
2013
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0191-8869
文章类型期刊论文
卷号103期号:3页码:467-473
产权排序1
摘要Antipsychotic drugs suppress animals' ability to avoid an aversive stimulus in the conditioned avoidance response model (CAR). This behavioral effect is thought to reflect antipsychotic activity and is suggested to be mediated by a drug's action in attenuating the motivational salience of a conditioned stimulus (CS). In the present study, we tested whether atypical antipsychotic drugs clozapine and olanzapine act through this behavioral mechanism by manipulating the number of avoidance test trials. We reasoned that more CS trials in the presence of clozapine or olanzapine would afford the drug more opportunities to decrease the motivational salience of the CS, thus avoidance decline would be greater with the increase of CS trials in each test session. In two separate experiments, adult male Sprague-Dawley rats were tested under clozapine (5.0 mg/kg, sc), olanzapine (0.5 mg/kg, sc) or vehicle (sterile water) for 6 consecutive days in three CS trial conditions (i.e. 3, 10, and 40 CS trials per session). Two days later, all rats were tested under the same 40-trial session after receiving clozapine (5.0 mg/kg, sc) or olanzapine (0.5 mg/kg, sc). Results show that repeated clozapine and olanzapine treatment persistently decreased avoidance response, and this effect was potentiated by the increase of number of CS trials in the test sessions, as the clozapine-treated or olanzapine-treated rats tested under the 40-trial or 10-trial condition had significantly lower avoidance and faster decline across-sessions than those tested under the 3-trial condition. This potentiated effect was not only seen in the total avoidance percentage, but also observed in the within-session decline pattern in the last three drug test sessions and in the final 40-trial test session. These findings suggest that the clinical efficacy of a drug can be enhanced by increasing the exposure of symptoms in the presence of the drug. (c) 2012 Elsevier Inc. All rights reserved.
关键词Clozapine Olanzapine Conditioned avoidance response Motivational salience Within-session decline
学科领域Personality Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者NIMH grant [R01MH085635]
项目简介This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li.
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
WOS记录号WOS:000314792100007
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTIPSYCHOTIC-DRUGS ; LINKING BIOLOGY ; TIME-COURSE ; IN-VIVO ; DOPAMINE ; CHLORPROMAZINE ; RATS ; SCHIZOPHRENIA ; PSYCHOSIS ; PHARMACOLOGY
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10706
专题中国科学院心理健康重点实验室
通讯作者Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Feng, Min,Sui, Nan,Li, Ming,et al. Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2013,103(3):467-473.
APA Feng, Min,Sui, Nan,Li, Ming,&Sui, N .(2013).Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,103(3),467-473.
MLA Feng, Min,et al."Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 103.3(2013):467-473.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000314792100007.(617KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
百度学术
百度学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
必应学术
必应学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。