Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis

	Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis
	Feng, Min1,2,3 ; Sui, Nan1 ; Li, Ming 2; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Antipsychotic drugs suppress animals' ability to avoid an aversive stimulus in the conditioned avoidance response model (CAR). This behavioral effect is thought to reflect antipsychotic activity and is suggested to be mediated by a drug's action in attenuating the motivational salience of a conditioned stimulus (CS). In the present study, we tested whether atypical antipsychotic drugs clozapine and olanzapine act through this behavioral mechanism by manipulating the number of avoidance test trials. We reasoned that more CS trials in the presence of clozapine or olanzapine would afford the drug more opportunities to decrease the motivational salience of the CS, thus avoidance decline would be greater with the increase of CS trials in each test session. In two separate experiments, adult male Sprague-Dawley rats were tested under clozapine (5.0 mg/kg, sc), olanzapine (0.5 mg/kg, sc) or vehicle (sterile water) for 6 consecutive days in three CS trial conditions (i.e. 3, 10, and 40 CS trials per session). Two days later, all rats were tested under the same 40-trial session after receiving clozapine (5.0 mg/kg, sc) or olanzapine (0.5 mg/kg, sc). Results show that repeated clozapine and olanzapine treatment persistently decreased avoidance response, and this effect was potentiated by the increase of number of CS trials in the test sessions, as the clozapine-treated or olanzapine-treated rats tested under the 40-trial or 10-trial condition had significantly lower avoidance and faster decline across-sessions than those tested under the 3-trial condition. This potentiated effect was not only seen in the total avoidance percentage, but also observed in the within-session decline pattern in the last three drug test sessions and in the final 40-trial test session. These findings suggest that the clinical efficacy of a drug can be enhanced by increasing the exposure of symptoms in the presence of the drug. (c) 2012 Elsevier Inc. All rights reserved.
关键词	Clozapine Olanzapine Conditioned avoidance response Motivational salience Within-session decline
学科领域	Personality Psychology
	2013
语种	英语
发表期刊	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN	0191-8869
卷号	103 期号:3 页码:467-473
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li.
WOS关键词	ANTIPSYCHOTIC-DRUGS ; LINKING BIOLOGY ; TIME-COURSE ; IN-VIVO ; DOPAMINE ; CHLORPROMAZINE ; RATS ; SCHIZOPHRENIA ; PSYCHOSIS ; PHARMACOLOGY
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目	Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
WOS记录号	WOS:000314792100007
资助机构	NIMH grant [R01MH085635]
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10706
专题	中国科学院心理健康重点实验室
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA 3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Feng, Min,Sui, Nan,Li, Ming,et al. Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2013,103(3):467-473.
APA	Feng, Min,Sui, Nan,Li, Ming,&Sui, N .(2013).Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,103(3),467-473.
MLA	Feng, Min,et al."Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: Further test of the motivational salience hypothesis".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 103.3(2013):467-473.

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