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Intrinsic Resting-State Activity Predicts Working Memory Brain Activation and Behavioral Performance
Zou, Qihong1,2,3,4; Ross, Thomas J.1; Gu, Hong1; Geng, Xiujuan1; Zuo, Xi-Nian5,6; Hong, L. Elliot7; Gao, Jia-Hong2,3,8; Stein, Elliot A.1; Zang, Yu-Feng4,9; Yang, Yihong1; Yang, YH (reprint author), NIDA, Neuroimaging Res Branch, NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA.
2013
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
Subtype期刊论文
Volume34Issue:12Pages:3204-3215
Contribution Rank4,5
AbstractAlthough resting-state brain activity has been demonstrated to correspond with task-evoked brain activation, the relationship between intrinsic and evoked brain activity has not been fully characterized. For example, it is unclear whether intrinsic activity can also predict task-evoked deactivation and whether the rest-task relationship is dependent on task load. In this study, we addressed these issues on 40 healthy control subjects using resting-state and task-driven [N-back working memory (WM) task] functional magnetic resonance imaging data collected in the same session. Using amplitude of low-frequency fluctuation (ALFF) as an index of intrinsic resting-state activity, we found that ALFF in the middle frontal gyrus and inferior/superior parietal lobules was positively correlated with WM task-evoked activation, while ALFF in the medial prefrontal cortex, posterior cingulate cortex, superior frontal gyrus, superior temporal gyrus, and fusiform gyrus was negatively correlated with WM task-evoked deactivation. Further, the relationship between the intrinsic resting-state activity and task-evoked activation in lateral/superior frontal gyri, inferior/superior parietal lobules, superior temporal gyrus, and midline regions was stronger at higher WM task loads. In addition, both resting-state activity and the task-evoked activation in the superior parietal lobule/precuneus were significantly correlated with the WM task behavioral performance, explaining similar portions of intersubject performance variance. Together, these findings suggest that intrinsic resting-state activity facilitates or is permissive of specific brain circuit engagement to perform a cognitive task, and that resting activity can predict subsequent task-evoked brain responses and behavioral performance. Hum Brain Mapp 34:3204-3215, 2013. (c) 2012 Wiley Periodicals, Inc.
Keywordresting-state fMRI ALFF N-back working memory load dependency behavior
Subject AreaCognitive Neuroscience
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Indexed BySCI
Language英语
Funding OrganizationIntramural Research Program of the National Institute on Drug Abuse (NIDA) ; National Institutes of Health (NIH) ; Natural Science Foundation of China [81020108022] ; China's National Strategic Basic Research Program (973) [2012CB720700]
Project Intro.Contract grant sponsors: Intramural Research Program of the National Institute on Drug Abuse (NIDA) and National Institutes of Health (NIH); Contract grant sponsor: Natural Science Foundation of China; Contract grant number: 81020108022; Contract grant sponsor: China's National Strategic Basic Research Program (973); Contract grant number: 2012CB720700.
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000326068700008
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL CONNECTIVITY ; VISUAL-CORTEX ; INTERINDIVIDUAL DIFFERENCES ; PREFRONTAL CORTEX ; MOTOR CORTEX ; DEFAULT MODE ; TASK ; FMRI ; MRI ; VARIABILITY
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Cited Times:99[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10707
Collection中国科学院行为科学重点实验室
Corresponding AuthorYang, YH (reprint author), NIDA, Neuroimaging Res Branch, NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA.
Affiliation1.NIDA, Neuroimaging Res Branch, NIH, Baltimore, MD 21224 USA
2.Peking Univ, MRI Res Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Beijing City Key Lab Med Phys & Engn, Beijing 100871, Peoples R China
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
7.Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
8.Univ Chicago, Brain Res Imaging Ctr, Chicago, IL 60637 USA
9.Hangzhou Normal Univ, Affiliated Hosp, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qihong,Ross, Thomas J.,Gu, Hong,et al. Intrinsic Resting-State Activity Predicts Working Memory Brain Activation and Behavioral Performance[J]. HUMAN BRAIN MAPPING,2013,34(12):3204-3215.
APA Zou, Qihong.,Ross, Thomas J..,Gu, Hong.,Geng, Xiujuan.,Zuo, Xi-Nian.,...&Yang, YH .(2013).Intrinsic Resting-State Activity Predicts Working Memory Brain Activation and Behavioral Performance.HUMAN BRAIN MAPPING,34(12),3204-3215.
MLA Zou, Qihong,et al."Intrinsic Resting-State Activity Predicts Working Memory Brain Activation and Behavioral Performance".HUMAN BRAIN MAPPING 34.12(2013):3204-3215.
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