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Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference
Qi, Keke1,2; Wei, Chuguang3; Li, Yonghui1; Sui, Nan1; Li, YH (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
文章类型期刊论文
卷号7
产权排序1
摘要Orexins are found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress induced drug seeking remains unknown. The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission. In the present study, amorphine conditioned place preference (CPP) model was used to determine whether the two types of orexin receptors would be involved into footshock-induced and/or drug priming-induced CPP reinstatement differentially. The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming induced reinstatement. These findings indicate that the NAcSh is a brain area through which orexins participate in stress but not drug priming-induced relapse of opioid seeking.
关键词orexin the nucleus accumbens shell morphine CPP stress-induced reinstatement drug priming-induced reinstatement
学科领域Physiological Psychology/biological Psychology
收录类别SCI
语种英语
项目资助者Chinese Academy of Sciences [KSCX2-EW-R-12, KSCX2-EW-Q-18] ; National Basic Research Program [2009CB522002] ; National Natural Science Foundation [31070911, 31170988, 31200770] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31070911, 31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000325460700001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]COCAINE-SEEKING BEHAVIOR ; VENTRAL TEGMENTAL AREA ; MESOLIMBIC DOPAMINE ; RAT-BRAIN ; HYPOTHALAMIC NEUROPEPTIDES ; PREFRONTAL CORTEX ; FEEDING-BEHAVIOR ; SLEEP REGULATION ; REWARD-SEEKING ; NEURONS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10709
专题中国科学院心理健康重点实验室
通讯作者Li, YH (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Core Facil, Beijing 100101, Peoples R China
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Qi, Keke,Wei, Chuguang,Li, Yonghui,et al. Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2013,7.
APA Qi, Keke,Wei, Chuguang,Li, Yonghui,Sui, Nan,&Li, YH .(2013).Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,7.
MLA Qi, Keke,et al."Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 7(2013).
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