PSYCH OpenIR  > 中国科学院心理健康重点实验室
Accumulated hippocampal formaldehyde induces age-dependent memory decline
Tong, Zhiqian1; Han, Chanshuai1; Luo, Wenhong2; Wang, Xiaohui4,5; Li, Hui2; Luo, Hongjun2; Zhou, Jiangning3; Qi, Jinshun4,5; He, Rongqiao6,7
2013-06-01
Source PublicationAGE
SubtypeArticle
Volume35Issue:3Pages:583-596
AbstractAging is an important factor in memory decline in aged animals and humans and in Alzheimer's disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and down-regulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memory-deteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague-Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-d-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases.
KeywordAlzheimer's disease (AD) Aging Endogenous formaldehyde Long-term potentiation (LTP) Long-term memory (LTM) NMDA receptor
Indexed BySCI
Language英语
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:000318174100006
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordLONG-TERM POTENTIATION ; NMDA RECEPTOR SUBUNITS ; ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; SYNAPTIC PLASTICITY ; RAT-BRAIN ; IN-VIVO ; ALDEHYDE DEHYDROGENASE ; FRONTAL-CORTEX ; SPINAL-CORD
Citation statistics
Cited Times:82[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10711
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Grad Univ, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
4.Shanxi Med Univ, Dept Neurobiol, Taiyuan 030001, Peoples R China
5.Shanxi Med Univ, Natl Key Discipline Physiol, Taiyuan 030001, Peoples R China
6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline[J]. AGE,2013,35(3):583-596.
APA Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Wang, Xiaohui.,Li, Hui.,...&He, Rongqiao.(2013).Accumulated hippocampal formaldehyde induces age-dependent memory decline.AGE,35(3),583-596.
MLA Tong, Zhiqian,et al."Accumulated hippocampal formaldehyde induces age-dependent memory decline".AGE 35.3(2013):583-596.
Files in This Item:
File Name/Size DocType Version Access License
WOS000318174100006.p(913KB)期刊论文出版稿限制开放Apache LicenseView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tong, Zhiqian]'s Articles
[Han, Chanshuai]'s Articles
[Luo, Wenhong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tong, Zhiqian]'s Articles
[Han, Chanshuai]'s Articles
[Luo, Wenhong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tong, Zhiqian]'s Articles
[Han, Chanshuai]'s Articles
[Luo, Wenhong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000318174100006.pdf.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.