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Accumulated hippocampal formaldehyde induces age-dependent memory decline
Tong, Zhiqian1; Han, Chanshuai1; Luo, Wenhong2; Wang, Xiaohui4,5; Li, Hui2; Luo, Hongjun2; Zhou, Jiangning3; Qi, Jinshun4,5; He, Rongqiao6,7
2013-06-01
发表期刊AGE
文章类型Article
卷号35期号:3页码:583-596
摘要Aging is an important factor in memory decline in aged animals and humans and in Alzheimer's disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and down-regulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memory-deteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague-Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-d-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases.
关键词Alzheimer's disease (AD) Aging Endogenous formaldehyde Long-term potentiation (LTP) Long-term memory (LTM) NMDA receptor
收录类别SCI
语种英语
WOS研究方向Geriatrics & Gerontology
WOS类目Geriatrics & Gerontology
WOS记录号WOS:000318174100006
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]LONG-TERM POTENTIATION ; NMDA RECEPTOR SUBUNITS ; ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; SYNAPTIC PLASTICITY ; RAT-BRAIN ; IN-VIVO ; ALDEHYDE DEHYDROGENASE ; FRONTAL-CORTEX ; SPINAL-CORD
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被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10711
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Grad Univ, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
4.Shanxi Med Univ, Dept Neurobiol, Taiyuan 030001, Peoples R China
5.Shanxi Med Univ, Natl Key Discipline Physiol, Taiyuan 030001, Peoples R China
6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline[J]. AGE,2013,35(3):583-596.
APA Tong, Zhiqian.,Han, Chanshuai.,Luo, Wenhong.,Wang, Xiaohui.,Li, Hui.,...&He, Rongqiao.(2013).Accumulated hippocampal formaldehyde induces age-dependent memory decline.AGE,35(3),583-596.
MLA Tong, Zhiqian,et al."Accumulated hippocampal formaldehyde induces age-dependent memory decline".AGE 35.3(2013):583-596.
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