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The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat
Zhang, Rui-Rui; Zhang, Wen-Cai; Wang, Jin-Yan; Guo, Jian-You
2013-05-01
Source PublicationINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
SubtypeArticle
Volume16Issue:4Pages:849-856
AbstractPlacebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that placebo analgesia activated the m-opioid receptor signalling in the human brain. However, whether other opioid receptors are involved in the placebo analgesia remains unclear. We have previously evoked placebo responses in mice (Guo et al. 2010, 2011) and these mice may serve as a model for investigating placebo analgesia. In the present study, we tried to explore the site of action and types of opioid receptors involved in placebo response. Male Sprague-Dawley rats were trained with 10 mg/kg morphine for 4 d to establish the placebo analgesia model. This placebo analgesia can be blocked by injection of 5 mg/kg dose naloxone or by microinjection with naloxone (1, 3 or 10 mu g/rat) into rostral anterior cingulate cortex (rACC). Then, animals were tested after intra-rACC microinjection of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP, a selective m-opioid receptor antagonist) or naltrindole (NTI, a highly selective delta-opioid receptor antagonist) or nor-binaltorphimine (nor-BNI, a highly selective kappa-opioid receptor antagonist). Our results showed that CTOP, but not NTI or nor-BNI, could reduce the pain threshold in placebo analgesia rats. It may be concluded that rACC is the key brain region involved in placebo analgesia and the opioid placebo analgesia is mediated exclusively through m-opioid receptor in rat.
KeywordPlacebo Analgesia Rat Rostral Anterior Cingulate Cortex Mu-opioid Receptor
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000316991800014
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordANTERIOR CINGULATE ; MICE LACKING ; RESPONSES ; MECHANISMS ; PAIN ; CHOLECYSTOKININ ; ACTIVATION ; NEUROTRANSMISSION ; DISSECTION ; DEPRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10715
Collection中国科学院心理健康重点实验室
AffiliationChinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,et al. The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(4):849-856.
APA Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,&Guo, Jian-You.(2013).The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,16(4),849-856.
MLA Zhang, Rui-Rui,et al."The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 16.4(2013):849-856.
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