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The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat
Zhang, Rui-Rui; Zhang, Wen-Cai; Wang, Jin-Yan; Guo, Jian-You
2013-05-01
发表期刊INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
文章类型Article
卷号16期号:4页码:849-856
摘要Placebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that placebo analgesia activated the m-opioid receptor signalling in the human brain. However, whether other opioid receptors are involved in the placebo analgesia remains unclear. We have previously evoked placebo responses in mice (Guo et al. 2010, 2011) and these mice may serve as a model for investigating placebo analgesia. In the present study, we tried to explore the site of action and types of opioid receptors involved in placebo response. Male Sprague-Dawley rats were trained with 10 mg/kg morphine for 4 d to establish the placebo analgesia model. This placebo analgesia can be blocked by injection of 5 mg/kg dose naloxone or by microinjection with naloxone (1, 3 or 10 mu g/rat) into rostral anterior cingulate cortex (rACC). Then, animals were tested after intra-rACC microinjection of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP, a selective m-opioid receptor antagonist) or naltrindole (NTI, a highly selective delta-opioid receptor antagonist) or nor-binaltorphimine (nor-BNI, a highly selective kappa-opioid receptor antagonist). Our results showed that CTOP, but not NTI or nor-BNI, could reduce the pain threshold in placebo analgesia rats. It may be concluded that rACC is the key brain region involved in placebo analgesia and the opioid placebo analgesia is mediated exclusively through m-opioid receptor in rat.
关键词Placebo Analgesia Rat Rostral Anterior Cingulate Cortex Mu-opioid Receptor
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000316991800014
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTERIOR CINGULATE ; MICE LACKING ; RESPONSES ; MECHANISMS ; PAIN ; CHOLECYSTOKININ ; ACTIVATION ; NEUROTRANSMISSION ; DISSECTION ; DEPRESSION
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10715
专题中国科学院心理健康重点实验室
作者单位Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,et al. The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(4):849-856.
APA Zhang, Rui-Rui,Zhang, Wen-Cai,Wang, Jin-Yan,&Guo, Jian-You.(2013).The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,16(4),849-856.
MLA Zhang, Rui-Rui,et al."The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 16.4(2013):849-856.
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