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Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV Risk and HIV Natural History
Proudnikov, Dmitri1; Randesi, Matthew1; Levran, Orna1; Yuferov, Vadim1; Crystal, Howard2; Ho, Ann1; Ott, Jurg3,4; Kreek, Mary J.1; Proudnikov, D (reprint author), Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave,Box 171, New York, NY 10065 USA.
2013
Source PublicationJAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
ISSN0091-0627
Subtype期刊论文
Volume63Issue:1Pages:17-26
Contribution Rank3
AbstractObjective: Studies indicate cross-desensitization between opioid receptors (eg, kappa opioid receptor, OPRK1) and chemokine receptors (eg, CXCR4) involved in HIV infection. Whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy was tested. Methods: Three study points, admission to the Women's Interagency HIV Study, initiation of highly active antiretroviral therapy (HAART), and the most recent visit, were chosen for analysis as crucial events in the clinical history of the HIV patients. Regression analyses of 17 variants of OPRK1 and 11 variants of PDYN with change of viral load (VL) and CD4 count between admission and initiation of HAART and initiation of HAART to the most recent visit to Women's Interagency HIV Study were performed in 598 HIV+ subjects, including African Americans, Hispanics, and Whites. Association with HIV status was done in 1009 subjects. Results: Before HAART, greater VL decline (improvement) in carriers of PDYN IVS3+189C>T and greater increase of CD4 count (improvement) in carriers of OPRK -72C>T were found in African Americans. Also, greater increase of CD4 count in carriers of OPRK1 IVS2+7886A>G and greater decline of CD4 count (deterioration) in carriers of OPRK1 - 21205G>A were found in Whites. After HAART, greater decline of VL in carriers of OPRK1 IVS2+ 2225G. A and greater increase of VL in carriers of OPRK1 IVS2+ 10658G. T and IVS2+ 10963A. G were found in Whites. Also, a lesser increase of CD4 count was found in Hispanic carriers of OPRK1 IVS2 + 2225G. A. Conclusions: OPRK1 and PDYN polymorphisms may alter severity of HIV infection and response to treatment.
Keywordpolymorphism SNP viral load CD4 count WIHS OPRK1 PDYN
Subject AreaPhysiological Psychology/biological Psychology,Medical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNIH-NIDA [P60-DA05130] ; NIH-NIMH [MH79880, MH076537] ; National Institute of Allergy and Infectious Diseases [UO1-AI- 35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590] ; Eunice Kennedy Shriver National Institute of Child Health and Human Development [UO1-HD-32632] ; National Cancer Institute ; National Institute on Drug Abuse ; National Institute on Deafness and Other Communication Disorders ; National Center for Research Resources (UCSF-CTSI) [UL1 RR024131]
Project Intro.Supported by NIH-NIDA P60-DA05130 (M. J. Kreek), NIH-NIMH MH79880 (M. J. Kreek), and NIH-NIMH MH076537 (H. Crystal). The WIHS is funded by the National Institute of Allergy and Infectious Diseases (UO1-AI- 35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (UO1-HD-32632). The study is co-funded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (UCSF-CTSI Grant Number UL1 RR024131).
WOS Research AreaImmunology ; Infectious Diseases
WOS SubjectImmunology ; Infectious Diseases
WOS IDWOS:000319112200012
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordBIDIRECTIONAL HETEROLOGOUS DESENSITIZATION ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; NEW-YORK-CITY ; DISEASE PROGRESSION ; CHEMOKINE RECEPTORS ; CD4(+) LYMPHOCYTES ; OPIATE ADDICTION ; DRUG-USERS ; ASSOCIATION ; EXPRESSION
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10721
Collection健康与遗传心理学研究室
Corresponding AuthorProudnikov, D (reprint author), Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave,Box 171, New York, NY 10065 USA.
Affiliation1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Suny Downstate Med Ctr, Dept Pathol, Brooklyn, NY 11203 USA
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
Recommended Citation
GB/T 7714
Proudnikov, Dmitri,Randesi, Matthew,Levran, Orna,et al. Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV Risk and HIV Natural History[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,2013,63(1):17-26.
APA Proudnikov, Dmitri.,Randesi, Matthew.,Levran, Orna.,Yuferov, Vadim.,Crystal, Howard.,...&Proudnikov, D .(2013).Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV Risk and HIV Natural History.JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,63(1),17-26.
MLA Proudnikov, Dmitri,et al."Polymorphisms of the Kappa Opioid Receptor and Prodynorphin Genes: HIV Risk and HIV Natural History".JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 63.1(2013):17-26.
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