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Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression
Liu, Chun-Hong; Ma, Xin; Wu, Xia; Zhang, Yu; Zhou, Fu-Chun; Li, Feng; Tie, Chang-Le; Dong, Jie; Wang, Yong-Jun; Yang, Zhi; Wang, Chuan-Yue; Ma, X (reprint author), Capital Med Univ, Beijing Anding Hosp, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China.
Contribution Rank7
AbstractObjective: Bipolar disorder patients experiencing a depressive episode (BD-dep) without an observed history of mania are often misdiagnosed and are consequently treated as having unipolar depression CUD), leading to inadequate treatment and poor outcomes. An essential solution to this problem is to identify objective biological markers that distinguish BD-dep and UD patients at an early stage. However, studies directly comparing the brain dysfunctions associated with BD-dep and UD are rare. More importantly, the specificity of the differences in brain activity between these mental disorders has not been examined. With whole-brain regional homogeneity analysis and region-of-interest (ROI) based receiver operating characteristic (ROC) analysis, we aimed to compare the resting-state brain activity of BD-dep and UD patients. Furthermore, we examined the specific differences and whether these differences were attributed to the brain abnormality caused by BD-dep, UD, or both. Methods: Twenty-one bipolar and 21 unipolar depressed patients, as well as 26 healthy subjects matched for gender, age, and educational levels, participated in the study. We compared the differences in the regional homogeneity (ReHo) of the BD-dep and UD groups and further identified their pathophysiological abnormality. In the brain regions showing a difference between the BD-dep and UD groups, we further conducted receptive operation characteristic (ROC) analyses to confirm the effectiveness of the identified difference in classifying the patients. Results: We observed ReHo differences between the BD-dep and UD groups in the right ventrolateral middle frontal gyrus, right dorsal anterior insular, right ventral anterior insular, right cerebellum posterior gyrus, right posterior cingulate cortex, right parahippocampal gyrus, and left cerebellum anterior gyrus. Further ROI comparisons and ROC analysis on these ROIs showed that the right parahippocampal gyrus reflected abnormality specific to the BD-dep group, while the right middle frontal gyrus, the right dorsal anterior insular, the right cerebellum posterior gyrus, and the right posterior cingulate cortex showed abnormality specific to the UD group. Conclusions: We found brain regions showing resting state ReHo differences and examined their sensitivity and specificity, suggesting a potential neuroimaging biomarker to distinguish between BD-dep and UD patients. We further clarified the pathophysiological abnormality of these regions for each of the two patient populations. (C) 2012 Elsevier Inc. All rights reserved.
KeywordBipolar disorder Functional magnetic resonance imaging (fMRI) Regional homogeneity (ReHo) Resting-state Unipolar depression
Subject AreaAbnormal Psychology,
2013
Language英语
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
Volume41Pages:52-59
Subtype期刊论文
URL查看原文
Indexed BySCI
Project Intro.The authors gratefully acknowledge Beijing Normal University Imaging Center for Brain Research and Prof. Yu-Feng Zang for their contributions in MRI data acquisition. This study was supported by grants from the 11th Five-Year Key Program for Science and Technology Development of China (grant no. 2007BAI17B05), the National Science Foundations of China (NSFC, grant no. 81270023 and 30900366), the Program for Science and Technology of Beijing (grant no. D101107047810001), Beijing Key Laboratory of Brain Disorders (grant no. 2012NZDJ06), and the Capital Medical University Fundamental and Clinical Foundations of China (grant no. 12JL73).
WOS KeywordMODE NETWORK CONNECTIVITY ; ANTERIOR CINGULATE CORTEX ; MAJOR DEPRESSION ; FUNCTIONAL CONNECTIVITY ; MOOD DISORDERS ; PREFRONTAL CORTEX ; NEURAL ACTIVITY ; INSULAR CORTEX ; FMRI ; MRI
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000315324600009
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Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10728
Collection中国科学院行为科学重点实验室
Corresponding AuthorMa, X (reprint author), Capital Med Univ, Beijing Anding Hosp, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China.
AffiliationMa, X (reprint author), Capital Med Univ, Beijing Anding Hosp, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China.
Recommended Citation
GB/T 7714
Liu, Chun-Hong,Ma, Xin,Wu, Xia,et al. Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,41:52-59.
APA Liu, Chun-Hong.,Ma, Xin.,Wu, Xia.,Zhang, Yu.,Zhou, Fu-Chun.,...&Ma, X .(2013).Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,41,52-59.
MLA Liu, Chun-Hong,et al."Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 41(2013):52-59.
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