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Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
Liu, Xia1,2; Hong, Xiaohong1; Chan, Raymond C. K.3; Kong, Fanzhi1; Peng, Zhizhen1,4; Wan, Xiaona1,5; Wang, Changqing1,6; Cheng, Lu7; Hong, XH (reprint author), Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515065, Peoples R China.
2013
发表期刊PSYCHIATRY RESEARCH
ISSN0165-1781
文章类型期刊论文
卷号209期号:3页码:431-438
产权排序3
摘要The purpose of the current study was to explore the association of auditory P50 sensory gating (P50) and prepulse inhibition (PPI) of schizophrenia with polymorphisms in the CHRNA7 and COMT genes. One hundred and fourty patients with schizophrenia participated in this study. They were administered the tests P50 and PPI. Moreover, three single nucleotide polymorphisms (SNPs) (rs2337980, rs1909884 and rs883473) in CHRNA7 and three SNPs (rs4680, rs737865 and rs165599) in COMT were selected to be genotyped by polyacrylamide gel microarray techniques. P50 index showed significant reduction in S2 amplitude between wild-type and mutation groups in the COMT rs4680. S1 amplitude of mutation group in the COMT rs737865 was also lower compared to wild-type group. PPI index revealed a shorter pulse latency of mutation group in the rs4680. The suppression ratio of mutation group was lower in COMT rs165599. Negative findings were shown between comparisons in all the CHRNA7 SNPs. We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia. Futher studies with a larger number of subjects are needed to verify the present findings. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
关键词Patients with first episode schizophrenia Auditory evoked potential P50 Prepulse inhibition of startle reflex COMT CHRNA7
学科领域Medical Psychology,abnormal Psychology
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收录类别SCI
语种英语
项目资助者National "Tenth Five-year" Science and Technology Program [2002BA711A08] ; National Science Fund China [81088001] ; Chinese Academy of Sciences [KSCX2-EW-J-8] ; National Basic Research Programme (973 Programme) [2007CB512305]
项目简介This study was supported partially by a grant from the National "Tenth Five-year" Science and Technology Program (2002BA711A08), the National Science Fund China (81088001), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the National Basic Research Programme (973 Programme No. 2007CB512305).
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000326766300029
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PREPULSE INHIBITION DEFICITS ; P50 SUPPRESSION ; ACOUSTIC STARTLE ; CIGARETTE-SMOKING ; HUMAN BRAIN ; SENSORIMOTOR ; COMT ; METHYLTRANSFERASE ; RISK ; NORMALIZATION
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10731
专题脑与认知科学国家重点实验室
通讯作者Hong, XH (reprint author), Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515065, Peoples R China.
作者单位1.Shantou Univ, Coll Med, Mental Hlth Ctr, Shantou 515065, Peoples R China
2.Mental Hlth Hosp Jining, Jining, Peoples R China
3.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
4.Third Peoples Hosp Zhongshan, Zhongshan, Peoples R China
5.Seventh Hosp Qingdao, Qingdao, Peoples R China
6.Chron Dis Hosp Baoan Dist Shenzhen, Shenzhen, Guangdong, Peoples R China
7.Southeast Univ, Minist Educ, Key Lab Child Dev & Learning Sci, Nanjing, Jiangsu, Peoples R China
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Liu, Xia,Hong, Xiaohong,Chan, Raymond C. K.,et al. Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia[J]. PSYCHIATRY RESEARCH,2013,209(3):431-438.
APA Liu, Xia.,Hong, Xiaohong.,Chan, Raymond C. K..,Kong, Fanzhi.,Peng, Zhizhen.,...&Hong, XH .(2013).Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia.PSYCHIATRY RESEARCH,209(3),431-438.
MLA Liu, Xia,et al."Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia".PSYCHIATRY RESEARCH 209.3(2013):431-438.
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