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Functional Homotopic Changes in Multiple Sclerosis with Resting-State Functional MR Imaging
Zhou, Y.1; Milham, M.2; Zuo, X. -N.2,3; Kelly, C.2; Jaggi, H.1; Herbert, J.1; Grossman, R. I.1; Ge, Y.1; Ge, Y (reprint author), NYU, Sch Med, Ctr Biomed Imaging, Dept Radiol, 660 1st Ave,4th Floor, New York, NY 10016 USA.
2013
发表期刊AMERICAN JOURNAL OF NEURORADIOLOGY
ISSN0195-6108
文章类型期刊论文
卷号34期号:6页码:1180-1187
产权排序3
摘要BACKGROUND AND PURPOSE: CC is extensively involved in MS with interhemispheric dysfunction. The purpose of this study was to determine whether interhemispheric correlation is altered in MS by use of a recently developed RS-fMRI homotopy technique and whether these homotopic changes correlate with CC pathology. MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting MS and 24 age-matched healthy volunteers were studied with RS-fMRI and DTI acquired at 3T. The Pearson correlation of each pair of symmetric interhemispheric voxels of RS-fMRI time-series data was performed to compute VMHC, and z-transformed for subsequent group-level analysis. In addition, 5 CC segments in the midsagittal area and DTI-derived FA were measured to quantify interhemispheric microstructural changes and correlate with global and regional VMHC in MS. RESULTS: Relative to control participants, patients with MS exhibited an abnormal homotopic pattern with decreased VMHC in the primary visual, somatosensory, and motor cortices and increased VMHC in several regions associated with sensory processing and motor control including the insula, thalamus, pallidum, and cerebellum. The global VMHC correlates moderately with the average FA of the entire CC for all participants in both groups (r = 0.3; P = .03). CONCLUSIONS: Our data provide preliminary evidence of the potential usefulness of VMHC analyses for the detection of abnormalities of interhemispheric coordination in MS. We demonstrated that the whole-brain homotopic RS-fMRI pattern was altered in patients with MS, which was partially associated with the underlying structural degenerative changes of CC measured with FA.
学科领域Cognitive Neuroscience,Medical Psychology
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收录类别SCI
语种英语
项目资助者National Institutes of Health [R01NS029029] ; Natural Science Foundation of China [81171409]
项目简介This study was supported by the National Institutes of Health (grant R01NS029029) and the Natural Science Foundation of China (grant 81171409).
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000329847700018
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CORPUS-CALLOSUM ; CONNECTIVITY ; NETWORKS ; TRACTOGRAPHY ; VOLUME
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10732
专题中国科学院行为科学重点实验室
通讯作者Ge, Y (reprint author), NYU, Sch Med, Ctr Biomed Imaging, Dept Radiol, 660 1st Ave,4th Floor, New York, NY 10016 USA.
作者单位1.NYU, Sch Med, Radiol Ctr Biomed Imaging, New York, NY 10016 USA
2.NYU, Sch Med, Ctr Child Study, New York, NY 10016 USA
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Key Lab Behav Sci,Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
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Zhou, Y.,Milham, M.,Zuo, X. -N.,et al. Functional Homotopic Changes in Multiple Sclerosis with Resting-State Functional MR Imaging[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2013,34(6):1180-1187.
APA Zhou, Y..,Milham, M..,Zuo, X. -N..,Kelly, C..,Jaggi, H..,...&Ge, Y .(2013).Functional Homotopic Changes in Multiple Sclerosis with Resting-State Functional MR Imaging.AMERICAN JOURNAL OF NEURORADIOLOGY,34(6),1180-1187.
MLA Zhou, Y.,et al."Functional Homotopic Changes in Multiple Sclerosis with Resting-State Functional MR Imaging".AMERICAN JOURNAL OF NEURORADIOLOGY 34.6(2013):1180-1187.
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