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Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls
Wang, Pengyun1,2; Li, Juan1; Li, Huijie1; Zhang, Shouzi3; Li, J (reprint author), Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊BEHAVIORAL AND BRAIN FUNCTIONS
ISSN1744-9081
文章类型期刊论文
卷号9
产权排序1
摘要Background: It has been established that the overall performance of associative memory was disproportionately impaired in contrast to item memory in aMCI (Amnestic mild cognitive impairment) patients, but little is known about the specific aspects of the memory process that show differences between aMCI and healthy controls. By comparing an item-item associative learning test with an individual item learning test, the present study investigated whether the rate of learning was slower in associative memory than in item memory in aMCI. Furthermore, we examined whether deficits in intertrial acquisition and consolidation contributed to the potential disproportionate impairments in the learning rate of associative memory for aMCI patients. In addition, we further explored whether the aMCI-discriminative power of the associative memory test increases more than that of the item memory test when the number of learning-test trials increases. Methods: A group of 40 aMCI patients and 40 matched control participants were administered a standardized item memory test (Auditory Verbal Learning Test, AVLT) and a standardized associative memory test (Paired Associative Learning Test, PALT), as well as other neuropsychological tests and clinical assessments. Results: The results indicated that the learning rate deficits in aMCI patients were more obvious for associative memory than for item memory and that the deficits resulted from impairments in both intertrial acquisition and consolidation. In addition, the receiver operating characteristic curve and logistical regression analysis revealed that the discriminative power of the associative memory test for aMCI was larger than that of the item memory test, especially with more than one learning-test trials. Conclusions: Due to more deficits in learning rate of associative memory than that of item memory, the discriminative power for aMCI tended to be larger in associative memory than in item memory when the number of learning-test trials increased. It is suggested that associative memory tests with multiple trials may be particularly useful for early detection of aMCI.
关键词Mild cognitive impairment Associative memory Item memory Learning rate
学科领域Cognitive Psychology
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [31271108, 30911120494, 31070916] ; Chinese Academy of Sciences [KSCX2-EW-J-8] ; CAS/SAFEA International Partnership Program for Creative Research Team [Y2CX131003] ; Institute of Psychology, Chinese Academy of Sciences [111000C038]
项目简介We thank Xin Huang, Bing Li, Xin Li, Xinyi Zhu, Tingji Chen, Jing Yu, Ting Zhou, for their help with data collection. This study was supported by the National Natural Science Foundation of China (31271108, 30911120494 and 31070916); the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), the CAS/SAFEA International Partnership Program for Creative Research Team (Y2CX131003), and the Translational Research finding from Institute of Psychology, Chinese Academy of Sciences (111000C038).
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000323133200001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FREE-RECALL PERFORMANCE ; ALZHEIMERS-DISEASE ; SUBJECTIVE ORGANIZATION ; PROGRESSION ; ADULTS ; DECOMPOSITION ; INDIVIDUALS ; SENSITIVITY ; ACQUISITION ; DEMENTIA
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10735
专题中国科学院心理健康重点实验室
通讯作者Li, J (reprint author), Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Beijing Geriatr Hosp, Beijing, Peoples R China
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GB/T 7714
Wang, Pengyun,Li, Juan,Li, Huijie,et al. Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2013,9.
APA Wang, Pengyun,Li, Juan,Li, Huijie,Zhang, Shouzi,&Li, J .(2013).Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls.BEHAVIORAL AND BRAIN FUNCTIONS,9.
MLA Wang, Pengyun,et al."Differences in learning rates for item and associative memories between amnestic mild cognitive impairment and healthy controls".BEHAVIORAL AND BRAIN FUNCTIONS 9(2013).
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