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Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats
Xue, Xiaofang1; Shao, Shuang1; Wang, Weiwen2; Shao, Feng1; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2013
发表期刊NEUROPSYCHOBIOLOGY
ISSN0302-282X
文章类型期刊论文
卷号68期号:4页码:243-249
产权排序2
摘要Aims: Early postnatal maternal and/or sibling separation (MS) can play an important role in the development of psychopathologies during ontogeny. The purpose of the present study is to investigate the effects of repeated MS on the cognitive and brain-derived neurotrophic factor (BDNF) function of rats. Methods: We investigated the effects of repeated MS that lasted 3 h/day during postnatal days 1-21 on spatial learning and reversal learning in Morris water maze tests in male rats. The rats were tested in 4 trials. Moreover, we examined the effects of MS on BDNF protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens, and the hippocampus via immunohistochemistry measurements. Results: We found that repeated MS modestly disrupted reversal learning performance in the Morris water maze and decreased BDNF protein expression in the mPFC. Conclusion: The present study enhances our understanding of the neurobiological and behavioral consequences of repeated episodes of MS in rats to some degree. (C) 2013 S. Karger AG, Basel
关键词Maternal and sibling separation Reversal learning Brain-derived neurotrophic factor Medial prefrontal cortex
学科领域Physiological Psychology/biological Psychology,Developmental Psychology
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This work was supported by the National Natural Science Foundation of China (grant No. 31070910 and 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS研究方向Neurosciences & Neurology ; Psychiatry ; Psychology
WOS类目Neurosciences ; Psychiatry ; Psychology
WOS记录号WOS:000328311900008
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]SPRAGUE-DAWLEY RATS ; PREFRONTAL CORTEX ; SOCIAL-ISOLATION ; COGNITIVE FLEXIBILITY ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; ISOLATION STRESS ; SCHIZOPHRENIA ; DEPRIVATION ; BDNF
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10736
专题中国科学院心理健康重点实验室
通讯作者Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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GB/T 7714
Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,et al. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats[J]. NEUROPSYCHOBIOLOGY,2013,68(4):243-249.
APA Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,Shao, Feng,&Shao, F .(2013).Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats.NEUROPSYCHOBIOLOGY,68(4),243-249.
MLA Xue, Xiaofang,et al."Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats".NEUROPSYCHOBIOLOGY 68.4(2013):243-249.
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