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Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats
Xue, Xiaofang1; Shao, Shuang1; Wang, Weiwen2; Shao, Feng1; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2013
Source PublicationNEUROPSYCHOBIOLOGY
ISSN0302-282X
Subtype期刊论文
Volume68Issue:4Pages:243-249
Contribution Rank2
AbstractAims: Early postnatal maternal and/or sibling separation (MS) can play an important role in the development of psychopathologies during ontogeny. The purpose of the present study is to investigate the effects of repeated MS on the cognitive and brain-derived neurotrophic factor (BDNF) function of rats. Methods: We investigated the effects of repeated MS that lasted 3 h/day during postnatal days 1-21 on spatial learning and reversal learning in Morris water maze tests in male rats. The rats were tested in 4 trials. Moreover, we examined the effects of MS on BDNF protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens, and the hippocampus via immunohistochemistry measurements. Results: We found that repeated MS modestly disrupted reversal learning performance in the Morris water maze and decreased BDNF protein expression in the mPFC. Conclusion: The present study enhances our understanding of the neurobiological and behavioral consequences of repeated episodes of MS in rats to some degree. (C) 2013 S. Karger AG, Basel
KeywordMaternal and sibling separation Reversal learning Brain-derived neurotrophic factor Medial prefrontal cortex
Subject AreaPhysiological Psychology/biological Psychology,Developmental Psychology
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.This work was supported by the National Natural Science Foundation of China (grant No. 31070910 and 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS Research AreaNeurosciences & Neurology ; Psychiatry ; Psychology
WOS SubjectNeurosciences ; Psychiatry ; Psychology
WOS IDWOS:000328311900008
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordSPRAGUE-DAWLEY RATS ; PREFRONTAL CORTEX ; SOCIAL-ISOLATION ; COGNITIVE FLEXIBILITY ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; ISOLATION STRESS ; SCHIZOPHRENIA ; DEPRIVATION ; BDNF
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10736
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
Affiliation1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,et al. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats[J]. NEUROPSYCHOBIOLOGY,2013,68(4):243-249.
APA Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,Shao, Feng,&Shao, F .(2013).Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats.NEUROPSYCHOBIOLOGY,68(4),243-249.
MLA Xue, Xiaofang,et al."Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats".NEUROPSYCHOBIOLOGY 68.4(2013):243-249.
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