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PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors
Wang, Li1; Cao, Chengqi1,2; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1; Zhang, Xiang Yang3; Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
发表期刊JOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
文章类型期刊论文
卷号150期号:1页码:156-159
产权排序1
摘要Background: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. Methods: Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. Results: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. Limitations: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. Conclusions: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology. (C) 2013 Elsevier B.V. All rights reserved.
关键词PTSD PAC1 receptor Single-nucleotide polymorphism Association study
学科领域Trauma Psychology
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收录类别SCI
语种英语
项目资助者Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-Q-18] ; National Natural Science Foundation of China [31271099, 30900402] ; Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
项目简介This study was supported by the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KSCX2-EW-Q-18), the National Natural Science Foundation of China (No. 31271099 and No. 30900402), the Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences, and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000322762600024
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]POSTTRAUMATIC-STRESS-DISORDER ; SEROTONIN TRANSPORTER GENOTYPE ; INDEPENDENT SAMPLES ; 5-FACTOR MODEL ; CHECKLIST ; EXPOSURE ; GENETICS ; VICTIMS ; SUPPORT ; TRAUMA
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10738
专题中国科学院心理健康重点实验室
通讯作者Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
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Wang, Li,Cao, Chengqi,Wang, Richu,et al. PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,150(1):156-159.
APA Wang, Li.,Cao, Chengqi.,Wang, Richu.,Qing, Yulan.,Zhang, Jianxin.,...&Wang, L .(2013).PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors.JOURNAL OF AFFECTIVE DISORDERS,150(1),156-159.
MLA Wang, Li,et al."PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors".JOURNAL OF AFFECTIVE DISORDERS 150.1(2013):156-159.
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