PSYCH OpenIR  > 中国科学院心理健康重点实验室
PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors
Wang, Li1; Cao, Chengqi1,2; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1; Zhang, Xiang Yang3; Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Subtype期刊论文
Volume150Issue:1Pages:156-159
Contribution Rank1
AbstractBackground: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. Methods: Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. Results: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. Limitations: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. Conclusions: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology. (C) 2013 Elsevier B.V. All rights reserved.
KeywordPTSD PAC1 receptor Single-nucleotide polymorphism Association study
Subject AreaTrauma Psychology
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Indexed BySCI
Language英语
Funding OrganizationKnowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-Q-18] ; National Natural Science Foundation of China [31271099, 30900402] ; Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Project Intro.This study was supported by the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KSCX2-EW-Q-18), the National Natural Science Foundation of China (No. 31271099 and No. 30900402), the Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences, and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000322762600024
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPOSTTRAUMATIC-STRESS-DISORDER ; SEROTONIN TRANSPORTER GENOTYPE ; INDEPENDENT SAMPLES ; 5-FACTOR MODEL ; CHECKLIST ; EXPOSURE ; GENETICS ; VICTIMS ; SUPPORT ; TRAUMA
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10738
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Li,Cao, Chengqi,Wang, Richu,et al. PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,150(1):156-159.
APA Wang, Li.,Cao, Chengqi.,Wang, Richu.,Qing, Yulan.,Zhang, Jianxin.,...&Wang, L .(2013).PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors.JOURNAL OF AFFECTIVE DISORDERS,150(1),156-159.
MLA Wang, Li,et al."PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors".JOURNAL OF AFFECTIVE DISORDERS 150.1(2013):156-159.
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