A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles

	A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles
	Yuasa, Isao 1; Jin, Feng2 ; Harihara, Shinji 3; Matsusue, Aya 4; Fujihara, Junko 5; Takeshita, Haruo 5; Akane, Atsushi 6; Umetsu, Kazuo 7; Saitou, Naruya 8; Chattopadhyay, Prasanta K.9
摘要	Previous studies of four populations revealed that a hypervariable short tandem repeat (iSTR) in intron 7 of the human complement factor I (CFI) gene on chromosome 4q was unique, with 17 possible East Asian-specific group H alleles observed at relatively high frequencies. To develop a deeper anthropological and forensic understanding of iSTR, 1161 additional individuals from 11 Asian populations were investigated. Group H alleles of iSTR and c.1217A allele of a SNP in exon 11 of the CFI gene were associated with each other and were almost entirely confined to East Asian populations. Han Chinese in Changsha, southern China, showed the highest frequency for East Asian-specific group H alleles (0.201) among 15 populations. Group H alleles were observed to decrease gradually from south to north in 11 East Asian populations. This expansion of group H alleles provides evidence that southern China and Southeast Asia are a hotspot of Asian diversity and a genetic reservoir of Asians after they entered East Asia. The expected heterozygosity values of iSTR ranged from 0.927 in Thais to 0.874 in Oroqens, higher than those of an STR in the fibrinogen alpha chain (FGA) gene on chromosome 4q. Thus, iSTR is a useful marker for anthropological and forensic genetics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
关键词	Asian-specific Complement factor I Geographic distribution Single-nucleotide polymorphism (SNP) Short tandem repeat (STR)
	2013-09-01
语种	英语
发表期刊	LEGAL MEDICINE
卷号	15 期号:5 页码:239-243
期刊论文类型	Article
收录类别	SSCI
WOS关键词	Y-CHROMOSOME EVIDENCE ; MUTATION-RATE ; POPULATIONS ; JAPANESE ; MICROSATELLITES ; SETTLEMENT ; D9S1120 ; LENGTH
WOS标题词	Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS研究方向	Legal Medicine ; Biomedical Social Sciences
WOS类目	Medicine, Legal ; Social Sciences, Biomedical
WOS记录号	WOS:000324357700003
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10741
专题	中国科学院心理健康重点实验室
作者单位	1.Tottori Univ, Fac Med, Div Legal Med, Yonago, Tottori 6838503, Japan 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan 4.Fukuoka Univ, Sch Med, Dept Forens Med, Fukuoka 81401, Japan 5.Shimane Univ, Fac Med, Dept Legal Med, Izumo, Shimane, Japan 6.Kansai Med Univ, Dept Legal Med, Hirakata, Osaka, Japan 7.Yamagata Univ, Fac Med, Dept Forens Med, Yamagata 990, Japan 8.Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 411, Japan 9.Amity Inst Forens Sci, New Delhi, India
推荐引用方式 GB/T 7714	Yuasa, Isao,Jin, Feng,Harihara, Shinji,et al. A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles[J]. LEGAL MEDICINE,2013,15(5):239-243.
APA	Yuasa, Isao.,Jin, Feng.,Harihara, Shinji.,Matsusue, Aya.,Fujihara, Junko.,...&Chattopadhyay, Prasanta K..(2013).A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles.LEGAL MEDICINE,15(5),239-243.
MLA	Yuasa, Isao,et al."A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles".LEGAL MEDICINE 15.5(2013):239-243.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS000324357700003.p（394KB）	学位论文		限制开放	Apache License	请求全文