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A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles
Yuasa, Isao1; Jin, Feng2; Harihara, Shinji3; Matsusue, Aya4; Fujihara, Junko5; Takeshita, Haruo5; Akane, Atsushi6; Umetsu, Kazuo7; Saitou, Naruya8; Chattopadhyay, Prasanta K.9
2013-09-01
发表期刊LEGAL MEDICINE
文章类型Article
卷号15期号:5页码:239-243
摘要Previous studies of four populations revealed that a hypervariable short tandem repeat (iSTR) in intron 7 of the human complement factor I (CFI) gene on chromosome 4q was unique, with 17 possible East Asian-specific group H alleles observed at relatively high frequencies. To develop a deeper anthropological and forensic understanding of iSTR, 1161 additional individuals from 11 Asian populations were investigated. Group H alleles of iSTR and c.1217A allele of a SNP in exon 11 of the CFI gene were associated with each other and were almost entirely confined to East Asian populations. Han Chinese in Changsha, southern China, showed the highest frequency for East Asian-specific group H alleles (0.201) among 15 populations. Group H alleles were observed to decrease gradually from south to north in 11 East Asian populations. This expansion of group H alleles provides evidence that southern China and Southeast Asia are a hotspot of Asian diversity and a genetic reservoir of Asians after they entered East Asia. The expected heterozygosity values of iSTR ranged from 0.927 in Thais to 0.874 in Oroqens, higher than those of an STR in the fibrinogen alpha chain (FGA) gene on chromosome 4q. Thus, iSTR is a useful marker for anthropological and forensic genetics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
关键词Asian-specific Complement factor I Geographic distribution Single-nucleotide polymorphism (SNP) Short tandem repeat (STR)
收录类别SSCI
语种英语
WOS研究方向Legal Medicine ; Biomedical Social Sciences
WOS类目Medicine, Legal ; Social Sciences, Biomedical
WOS记录号WOS:000324357700003
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]Y-CHROMOSOME EVIDENCE ; MUTATION-RATE ; POPULATIONS ; JAPANESE ; MICROSATELLITES ; SETTLEMENT ; D9S1120 ; LENGTH
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10741
专题中国科学院心理健康重点实验室
作者单位1.Tottori Univ, Fac Med, Div Legal Med, Yonago, Tottori 6838503, Japan
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan
4.Fukuoka Univ, Sch Med, Dept Forens Med, Fukuoka 81401, Japan
5.Shimane Univ, Fac Med, Dept Legal Med, Izumo, Shimane, Japan
6.Kansai Med Univ, Dept Legal Med, Hirakata, Osaka, Japan
7.Yamagata Univ, Fac Med, Dept Forens Med, Yamagata 990, Japan
8.Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 411, Japan
9.Amity Inst Forens Sci, New Delhi, India
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Yuasa, Isao,Jin, Feng,Harihara, Shinji,et al. A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles[J]. LEGAL MEDICINE,2013,15(5):239-243.
APA Yuasa, Isao.,Jin, Feng.,Harihara, Shinji.,Matsusue, Aya.,Fujihara, Junko.,...&Chattopadhyay, Prasanta K..(2013).A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles.LEGAL MEDICINE,15(5),239-243.
MLA Yuasa, Isao,et al."A hypervariable STR polymorphism in the CFI gene: Southern origin of East Asian-specific group H alleles".LEGAL MEDICINE 15.5(2013):239-243.
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